Protein Alignment Grip71 and nedd1

DIOPT Version :10

• Sequence 1: NP_609902.3
• Gene: Grip71 / 35130
• FlyBaseID: FBgn0032705
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_998671.2
• Gene: nedd1 / 406827
• ZFINID: ZDB-GENE-040426-2906
• Length: 675
• Species: Danio rerio
• Alignment Length: 667
• Identity: 144/667 - (21%)
• Similarity: 230/667 - (34%)
• Gaps: 213/667 - (31%)

  Fly    91 IAVGQSGCVKLYNFRTAQLIHRFPADPQRSTVLYMDYNNTDEYIAAVRDGGDISILGTKTKQKTN 155
            ::.|....|.:::.:|.:| ||...| .:..|..:.:|..|.|||:....|||.:....|...:.
Zfish    93 VSGGLDNTVNIWDLKTKRL-HRTLKD-HKEEVTCVSFNGGDSYIASGSTSGDIILHSITTNLSSK 155

  Fly   156 TFTIDGDSTLVRFHP-----SKRFHLSIASYKGAVTVYDVQGMRKIFHASEAHSAPCRDISMCTS 215
            .|   |....|..|.     .||..|...|..|:|.::|....:::.....||.|||..::...:
Zfish   156 PF---GHGPNVPIHDLRYSLVKRSLLGTVSDSGSVALWDANTQKELHLFEGAHKAPCSGLAFSPA 217

  Fly   216 QPALLVSVGYDCKINIFD-----IRRNRAQASTDRLTYSHPLSTVALSECGTYLCAGNLKGELIA 275
            ...|.|:||.|.||..:|     :.||:...|        ||:.:..:..|..|..|:.:|.:..
Zfish   218 NDLLFVTVGLDKKIVCYDTSSKIVFRNKQVES--------PLTAIDFTPDGAGLVVGSTQGRIYL 274

  Fly   276 YDMRSTKAPLAVRSVHDAAVTRVAF----------------------VPVPSGDNQQNGSLNSSE 318
            ||:|:..||:.:.:.|..:||.:.|                      :.|..|.:||.|.
Zfish   275 YDLRNLSAPVKINTAHKTSVTCIRFQNSTSKLKSTKSSSKSSQSNKRISVKLGSSQQTGP----- 334

  Fly   319 NATGLATEAPRVERA------------PSDELRKSIAANLLSTQNQL-----------TSLGYGV 360
             :|..:|..|.|..:            ||.|:....|...|| |:|:           .||...:
Zfish   335 -STPTSTVPPIVSGSEFPGDGQAQVPGPSAEVFSREAEGQLS-QDQMPNVEKFSSIGRNSLNLDI 397

  Fly   361 STPTIVRRDSFCE--FLD--------------AQGPRAVDRMSTRLGASYRDSF----------- 398
            .:|.   .|.|..  |.|              |:|.:..||.  |:|.:..|.|
Zfish   398 FSPL---NDGFKSHGFADTSRNGGSIDVFSREAEGQQTADRF--RVGRNSLDIFSPVRDDYKGHR 457

  Fly   399 ---------DWETL-------NRKPQPYETANRQSLCPPVASGPSSVDNSVNSSTTESLQQTLSG 447
                     |:|.|       :::..|..|...:...|.|...|...:   ..|||...|||
Zfish   458 LSDVSSGKKDFEYLPHFPGGSSQRKTPLGTPGSRCYSPSVVQTPPIKE---EESTTTPPQQT--- 516

  Fly   448 PLKDRSNISGDGKLMKIAETDELCEEQSANISVASSTGGGSDKENPPPVDAEMKRRLRLLSASRN 512
               |..|.:      |:.:::.:.:|.              |....||  |....|::.:....|
Zfish   517 ---DVQNGT------KVEKSNGVRQEY--------------DAITTPP--AAQSTRIQSVQPQFN 556

  Fly   513 STPHHANITPQSS------------NPLLK----PQQLLAKSSSGL------SAQMDADWRKEFS 555
                    ||:.|            :|:.:    |....|..::.:      |.||:........
Zfish   557 --------TPEPSQRRDLSTQLTYDSPISRAPAPPAAAAAAPAAAVDSAPLTSVQMNFVRNMIHE 613

  Fly   556 ELRDFVDQRCEKVERELEYVTFSNQRLLANKMTNYMDQQVENTR-------EIRDALALLLQGDS 613
            .|.||.| .|.:                     :.::.|||..|       ||...:......||
Zfish   614 ALEDFRD-TCHR---------------------DIINLQVEMVRQFYIQLNEIHGLIEKYSVNDS 656

  Fly   614 FMREFSRLQNENEMLKA 630
            .:.|..||:.||:.|:|
Zfish   657 LVEEIERLKEENKRLRA 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grip71	NP_609902.3	WD40	57..302	CDD:475233	59/242 (24%)
		WD40 repeat	78..114	CDD:293791	6/22 (27%)
		WD40 repeat	123..158	CDD:293791	9/34 (26%)
		WD40 repeat	165..201	CDD:293791	9/40 (23%)
		WD40 repeat	207..234	CDD:293791	9/31 (29%)
		WD40 repeat	252..289	CDD:293791	10/36 (28%)
nedd1	NP_998671.2	None