DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip71 and NEDD1

DIOPT Version :9

Sequence 1:	NP_609902.3	Gene:	Grip71 / 35130	FlyBaseID:	FBgn0032705	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001128647.1	Gene:	NEDD1 / 121441	HGNCID:	7723	Length:	667	Species:	Homo sapiens

Alignment Length:	641	Identity:	132/641 - (20%)
Similarity:	235/641 - (36%)	Gaps:	154/641 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 CVACAKQSLEEIAVGQSGCVKLYNFRTAQLIHRFPADPQRSTVLYMDYNNTDEYIAAVRDGGDIS 144
            ||.....|:..::.|.:..|.:::.::.: :||...| .:..|..:.||..|.|||:....|:|
Human    89 CVNLNSTSMYLVSGGLNNTVNIWDLKSKR-VHRSLKD-HKDQVTCVTYNWNDCYIASGSLSGEI- 150

  Fly   145 ILGTKTKQKTNTFTIDGDSTLVR---FHPSKRFHLSIASYKGAVTVYDVQGMRKIFHASEAHSAP 206
            ||.:.|...::|....|.:..||   :...|:..|...|..|.||::||.......:....|.||
Human   151 ILHSVTTNLSSTPFGHGSNQSVRHLKYSLFKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSVHKAP 215

  Fly   207 CRDISMCTSQPALLVSVGYDCKINIFDIRRNRAQASTDRLTYSHPLSTVALSECGTYLCAGNLKG 271
            ...|........|.|::|.|.:|.::|   ..::.....|....||:.|.....|..|..|:.:|
Human   216 ASGICFSPVNELLFVTIGLDKRIILYD---TSSKKLVKTLVADTPLTAVDFMPDGATLAIGSSRG 277

  Fly   272 ELIAYDMRSTKAPLAVRSVHDAAVTRVAF---------------VPVPSGDNQQNGSLNSSENA- 320
            ::..||:|..|:|:...|.|..:|..:||               ...|:..|:::.::|::...
Human   278 KIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTVLTKSSLNKGCSNKPTTVNKRSVNVNAASGGV 342

  Fly   321 --TGLATEAPRVERAPSDELRKSIAANLLSTQNQLTSLGYG-------------VSTPTIVRR-D 369
              :|:..|||..          |||..|  .|...:::|.|             ::|.|:.:. |
Human   343 QNSGIVREAPAT----------SIATVL--PQPMTSAMGKGTVAVQEKAGLPRSINTDTLSKETD 395

  Fly   370 S-----FCEFLDAQGPRAVDRMSTRL------------GASYRDSFDW-ETLN------RKPQPY 410
            |     |..| |..|..::..|.:.:            .....|.||: ..||      :.|...
Human   396 SGKNQDFSSF-DDTGKSSLGDMFSPIRDDAVVNKGSDESIGKGDGFDFLPQLNSVFPPRKNPVTS 459

  Fly   411 ETANRQSLCPPVASGPSSVDNSVNSSTTESLQQTLSGPLKDRSNISGDGKLMKIAETDELCEEQS 475
            .|:...|....|..|....:.:.|...|...::...|..:.:.:.....||:...     .|..:
Human   460 STSVLHSSPLNVFMGSPGKEENENRDLTAESKKIYMGKQESKDSFKQLAKLVTSG-----AESGN 519

  Fly   476 ANISVASSTGGGSDK-ENP-----------PPVDAEMKRRLRLLSASRNSTPHHANITPQSSNPL 528
            .|.|.:|:....|:| |.|           ||::.             :|||          ||
Human   520 LNTSPSSNQTRNSEKFEKPENEIEAQLICEPPING-------------SSTP----------NP- 560

  Fly   529 LKPQQLLAKSSSGLSAQMDADWRKEFSELRDFVDQRCEKVERELEYVTFSNQRLLANKMTNYMDQ 593
                ::.:..::|:::.:.       .::.|.:..     .|:...:|....|.:.|.:...:|.
Human   561 ----KIASSVTAGVASSLS-------EKIADSIGN-----NRQNAPLTSIQIRFIQNMIQETLDD 609

  Fly   594 ------------QVE-------NTREIRDALALLLQGDSFMREFSRLQNENEMLKA 630
                        |||       ...|:...|......:..:.|..||:.||:.|:|
Human   610 FREACHRDIVNLQVEMIKQFHMQLNEMHSLLERYSVNEGLVAEIERLREENKRLRA 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip71	NP_609902.3	WD40	57..302	CDD:295369	60/239 (25%)
		WD40 repeat	78..114	CDD:293791	7/33 (21%)
		WD40	<92..302	CDD:225201	57/227 (25%)
		WD40 repeat	123..158	CDD:293791	12/34 (35%)
		WD40 repeat	165..201	CDD:293791	10/38 (26%)
		WD40 repeat	207..234	CDD:293791	6/26 (23%)
		WD40 repeat	252..289	CDD:293791	11/36 (31%)
NEDD1	NP_001128647.1	WD40	<10..285	CDD:225201	52/201 (26%)
		WD40	31..306	CDD:238121	58/222 (26%)
		WD40 repeat	44..81	CDD:293791
		WD40 repeat	88..124	CDD:293791	7/35 (20%)
		WD40 repeat	130..167	CDD:293791	12/37 (32%)
		WD40 repeat	172..209	CDD:293791	10/36 (28%)
		WD40 repeat	217..253	CDD:293791	7/38 (18%)
		WD40 repeat	258..295	CDD:293791	11/36 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4378
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6204
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007355
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR44414
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5476
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.820