DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Faf2 and faf2

DIOPT Version :9

Sequence 1:	NP_001286057.1	Gene:	Faf2 / 35129	FlyBaseID:	FBgn0025608	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_001122152.1	Gene:	faf2 / 497596	ZFINID:	ZDB-GENE-050208-312	Length:	445	Species:	Danio rerio

Alignment Length:	462	Identity:	194/462 - (41%)
Similarity:	272/462 - (58%)	Gaps:	25/462 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EADGLTNEQTEKVLQFQDLTGIEDMNVCRDVLIRHQWDLEVAFQEQLNIREGRPTMFAASTDVRA 66
            |...|:..||||:||||||||:|.|:.||..|.:|.|::|.|.|::||.:||.|::|..     .
Zfish     5 EEQELSQAQTEKLLQFQDLTGLESMDQCRRTLEQHNWNIEAAVQDRLNEQEGVPSVFNP-----P 64

  Fly    67 PAVLNDRFLQQVFSANMPGGRTVSRVPSGPVPRSFTGIIGYVINFVFQYFYSTLTSIVSAFVNLG 131
            ||    |.||    .|....|..|.:.|.|.||...|...|:|...|::.|.||..|....:...
Zfish    65 PA----RPLQ----VNTTDHRVYSYIVSRPQPRGLIGWSYYLIMLPFRFTYYTLLDIFRFALRFI 121

  Fly   132 GGNEARLVTDPLGDVMKFIREYYERY-PEHPVFYQGTYAQALNDAKQELRFLIVYLHKDPAKNPD 195
            ..:....||||:||||.||..:.|:| ..|||||||||:|||||||:|||:|:||||.:  .:.|
Zfish   122 RPDPRGRVTDPVGDVMSFIHSFEEKYGRSHPVFYQGTYSQALNDAKRELRYLLVYLHGE--DHQD 184

  Fly   196 VESFCRNTLSARSVIDYINTHTLLWGCDVATPEGYRVMQSITVRSYPTMVMISLRANRMMIVGRF 260
            .:.|||:||.:...:.:|||..|.|.|..:.||||||.|::...:||.:.||.|:..:|.:|||.
Zfish   185 TDEFCRSTLCSEEALTFINTRMLFWACSTSKPEGYRVSQALRENTYPFLAMIMLKDRKMTVVGRL 249

  Fly   261 EGDCTPEELLRRLQSVTNANEVWLSQARADRLERNFTQTLRRQQDEAYEQSLLADEEKERQRQRE 325
            ||...||:|:.:|..:..||:.:|...|.:|.|||.||.||:|||||||.||.||:||:|:::.|
Zfish   250 EGLIQPEDLINQLTFIMEANQTYLMSERLEREERNQTQVLRQQQDEAYEASLRADQEKDRKKREE 314

  Fly   326 RDAVRQAEEAVEQARRDVELRKEEIARQKIELATLVPSEPAADAVGAIAVVFKLPSGTRLERRFN 390
            ::..||.||.|.|.....|.|:..:..:|...:..:|:||..|....:.:||:||:.||:||||.
Zfish   315 QEQKRQEEEKVRQTVLAEERRRRTLEEEKERRSECLPAEPPVDDPDGVKIVFRLPNDTRVERRFL 379

  Fly   391 QTDSVLDVYHYLFCHPDSPDEFEITTNFPKRVLFSKANLDAAGETGTAKETLTKTLQAVGLKNRE 455
            ...|:..::.:||...::|::|::.||:|:|||..         ..|..|....||...||...|
Zfish   380 FGQSLTVIHDFLFSLKETPEKFQVVTNYPRRVLPC---------LPTEDEPNPPTLMEAGLSRSE 435

  Fly   456 VLFVNDL 462
            ||||.||
Zfish   436 VLFVQDL 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Faf2	NP_001286057.1	UBA_FAF2	12..49	CDD:270597	20/36 (56%)
		UAS_ETEA	163..280	CDD:239289	55/116 (47%)
		ATP-synt_B	<287..>373	CDD:304375	37/85 (44%)
		UBQ	373..462	CDD:294102	32/88 (36%)
faf2	NP_001122152.1	UBA_FAF2	15..52	CDD:270597	20/36 (56%)
		UAS_ETEA	154..269	CDD:239289	55/116 (47%)
		Faf1_like2_UBX	358..442	CDD:176369	32/92 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574669
Domainoid	1	1.000	238	1.000	Domainoid score	I2246
eggNOG	1	0.900	-	-		E1_KOG1363
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8753
Inparanoid	1	1.050	344	1.000	Inparanoid score	I2308
OMA	1	1.010	-	-		QHG53584
OrthoDB	1	1.010	-	-		D1251507at2759
OrthoFinder	1	1.000	-	-		FOG0005640
OrthoInspector	1	1.000	-	-		oto39850
orthoMCL	1	0.900	-	-		OOG6_102329
Panther	1	1.100	-	-	LDO	PTHR23322
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2328
SonicParanoid	1	1.000	-	-		X5289
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800