DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Faf2 and FAF2

DIOPT Version :9

Sequence 1:	NP_001286057.1	Gene:	Faf2 / 35129	FlyBaseID:	FBgn0025608	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_055428.1	Gene:	FAF2 / 23197	HGNCID:	24666	Length:	445	Species:	Homo sapiens

Alignment Length:	462	Identity:	199/462 - (43%)
Similarity:	277/462 - (59%)	Gaps:	25/462 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EADGLTNEQTEKVLQFQDLTGIEDMNVCRDVLIRHQWDLEVAFQEQLNIREGRPTMFAASTDVRA 66
            |...||.|||||:||||||||||.|:.||..|.:|.|::|.|.|::||.:||.|::|      ..
Human     5 EERDLTQEQTEKLLQFQDLTGIESMDQCRHTLEQHNWNIEAAVQDRLNEQEGVPSVF------NP 63

  Fly    67 PAVLNDRFLQQVFSANMPGGRTVSRVPSGPVPRSFTGIIGYVINFVFQYFYSTLTSIVSAFVNLG 131
            |.   .|.||    .|....|..|.|.|.|.||...|...|:|...|::.|.|:..|....:...
Human    64 PP---SRPLQ----VNTADHRIYSYVVSRPQPRGLLGWGYYLIMLPFRFTYYTILDIFRFALRFI 121

  Fly   132 GGNEARLVTDPLGDVMKFIREYYERYPE-HPVFYQGTYAQALNDAKQELRFLIVYLHKDPAKNPD 195
            ..:....||||:||::.|:..:.|:|.. |||||||||:|||||||:|||||:||||.|  .:.|
Human   122 RPDPRSRVTDPVGDIVSFMHSFEEKYGRAHPVFYQGTYSQALNDAKRELRFLLVYLHGD--DHQD 184

  Fly   196 VESFCRNTLSARSVIDYINTHTLLWGCDVATPEGYRVMQSITVRSYPTMVMISLRANRMMIVGRF 260
            .:.||||||.|..||..|||..|.|.|....||||||.|::...:||.:.||.|:..||.:|||.
Human   185 SDEFCRNTLCAPEVISLINTRMLFWACSTNKPEGYRVSQALRENTYPFLAMIMLKDRRMTVVGRL 249

  Fly   261 EGDCTPEELLRRLQSVTNANEVWLSQARADRLERNFTQTLRRQQDEAYEQSLLADEEKERQRQRE 325
            ||...|::|:.:|..:.:||:.:|...|.:|.|||.||.||:||||||..||.||:||||:::.|
Human   250 EGLIQPDDLINQLTFIMDANQTYLVSERLEREERNQTQVLRQQQDEAYLASLRADQEKERKKREE 314

  Fly   326 RDAVRQAEEAVEQARRDVELRKEEIARQKIELATLVPSEPAADAVGAIAVVFKLPSGTRLERRFN 390
            |:..|:.||.|:|.:...|.|::.:..:|......:|.||:.|...::.::||||:.:|:||||:
Human   315 RERKRRKEEEVQQQKLAEERRRQNLQEEKERKLECLPPEPSPDDPESVKIIFKLPNDSRVERRFH 379

  Fly   391 QTDSVLDVYHYLFCHPDSPDEFEITTNFPKRVLFSKANLDAAGETGTAKETLTKTLQAVGLKNRE 455
            .:.|:..::.:||...:||::|:|..|||:|||....:.:...         ..|||..||.:.|
Human   380 FSQSLTVIHDFLFSLKESPEKFQIEANFPRRVLPCIPSEEWPN---------PPTLQEAGLSHTE 435

  Fly   456 VLFVNDL 462
            ||||.||
Human   436 VLFVQDL 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Faf2	NP_001286057.1	UBA_FAF2	12..49	CDD:270597	21/36 (58%)
		UAS_ETEA	163..280	CDD:239289	61/116 (53%)
		ATP-synt_B	<287..>373	CDD:304375	37/85 (44%)
		UBQ	373..462	CDD:294102	32/88 (36%)
FAF2	NP_055428.1	UBA_FAF2	15..52	CDD:270597	21/36 (58%)
		UAS_ETEA	154..269	CDD:239289	61/116 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	299..361		22/61 (36%)
		UBX_UBXN3B	362..441	CDD:340537	32/87 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141664
Domainoid	1	1.000	239	1.000	Domainoid score	I2297
eggNOG	1	0.900	-	-		E1_KOG1363
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8753
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53584
OrthoDB	1	1.010	-	-		D1251507at2759
OrthoFinder	1	1.000	-	-		FOG0005640
OrthoInspector	1	1.000	-	-		oto90072
orthoMCL	1	0.900	-	-		OOG6_102329
Panther	1	1.100	-	-	LDO	PTHR23322
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2328
SonicParanoid	1	1.000	-	-		X5289
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800