DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Faf2 and FAF1

DIOPT Version :9

Sequence 1:	NP_001286057.1	Gene:	Faf2 / 35129	FlyBaseID:	FBgn0025608	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_008982.1	Gene:	FAF1 / 11124	HGNCID:	3578	Length:	650	Species:	Homo sapiens

Alignment Length:	349	Identity:	95/349 - (27%)
Similarity:	168/349 - (48%)	Gaps:	58/349 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 GD-VMKFIREYYERYPE-HPVFYQGTYAQALNDA----KQELRFLIVYLHKDPAKNPDVESFCRN 202
            || :::|..|:..||.: ||||:.|:...|..:|    .::.:.|.:|||.|.:...:|  ||..
Human   331 GDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESVLTNV--FCSQ 393

  Fly   203 TLSARSVIDYINTHTLLWGCDVATPEGYRVMQSITVRSYPTMVMISLRANR-------MMIVGR- 259
            .|.|.|::.|::.:.:.|..|:..........::..|.:.::|..::|..:       ::|:|:
Human   394 MLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKR 458

  Fly   260 --------FEGDCTPEELLRRLQSVTNANEVWLSQAR---ADRLERNFTQTLRRQQDEAYEQSLL 313
                    .:|:.|.:||:.||.:   |.|::.:|.:   .|..||...:.::|:|||||..||.
Human   459 SSNEVLNVIQGNTTVDELMMRLMA---AMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLE 520

  Fly   314 ADEEKERQRQRERDAVRQAEE-AVEQARRDVELRKEEIARQKIELATLVPSEPA---ADAVGAIA 374
            ||..|....:||     .||: .:||.|::.|..:|.|   ::.|...:|.||.   |:.|..:.
Human   521 ADRAKREAHERE-----MAEQFRLEQIRKEQEEEREAI---RLSLEQALPPEPKEENAEPVSKLR 577

  Fly   375 VVFKLPSGTRLERRFNQTDSVLDVYHYLFCHPDSPDEFEITTNFPKRVLFSKANLDAAGETGTAK 439
            :  :.|||..|||||..::.:..|:.::.......||:::.:.||:|   ....||.
Human   578 I--RTPSGEFLERRFLASNKLQIVFDFVASKGFPWDEYKLLSTFPRR---DVTQLDP-------- 629

  Fly   440 ETLTKTLQAVGLKNREVLFVNDLE 463
               .|:|..|.|..:|.||:...|
Human   630 ---NKSLLEVKLFPQETLFLEAKE 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Faf2	NP_001286057.1	UBA_FAF2	12..49	CDD:270597
		UAS_ETEA	163..280	CDD:239289	29/136 (21%)
		ATP-synt_B	<287..>373	CDD:304375	30/92 (33%)
		UBQ	373..462	CDD:294102	23/88 (26%)
FAF1	NP_008982.1	UBA_FAF1	14..46	CDD:270596
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..87
		UAS_FAF1	352..487	CDD:239288	31/139 (22%)
		Stathmin	<471..559	CDD:279209	33/98 (34%)
		Faf1_UBX	570..649	CDD:176366	25/94 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1363
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2328
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840