DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jwa and Arl6ip5

DIOPT Version :9

Sequence 1:	NP_609901.5	Gene:	Jwa / 35128	FlyBaseID:	FBgn0032704	Length:	249	Species:	Drosophila melanogaster
Sequence 2:	NP_076462.1	Gene:	Arl6ip5 / 66028	RGDID:	708572	Length:	188	Species:	Rattus norvegicus

Alignment Length:	194	Identity:	68/194 - (35%)
Similarity:	105/194 - (54%)	Gaps:	25/194 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 NLQLPPLRTLDDFILGSARFQLPNLKDFEKWGNRVVKNLLYYQTNYFLLFITIYVLMIFFNP-SK 123
            ::.|.|||..|||..||.||..|:.:|..||.||||.|||||||||.::...:..::.|.:| :.
  Rat     2 DVNLAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQTNYLVVAAMMISVVGFLSPFNM 66

  Fly   124 IITGLLVQALIIGVIWQFFS----GKSKKNFIASRLTGGNANAAEQNAQQKWYILAGALLGGYLL 184
            |:.|::|..:..|.:|...:    .:.||.:..:                  :::. .:|..|.|
  Rat    67 ILGGIIVVLVFTGFVWAAHNKDILRRMKKQYPTA------------------FVMV-VMLASYFL 112

  Fly   185 LHLLSAVLLTIFTVLLPISLTFIHASLRLRNIKNKLTNSIESFA-PSTPMGSLLDALNVRAEGV 247
            :.:...|::.:|.:..|:.|.||||||||||:||||.|.:|... ..||||.:||||..:.:.:
  Rat   113 ISMFGGVMVFVFGITFPLLLMFIHASLRLRNLKNKLENKMEGIGLKKTPMGIILDALEQQEDSI 176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jwa	NP_609901.5	PRA1	62..220	CDD:281235	56/162 (35%)
Arl6ip5	NP_076462.1	PRA1	3..148	CDD:397359	56/163 (34%)
		Required for homodimer formation and heterodimer formation with ARL6IP1. /evidence=ECO:0000250\|UniProtKB:Q8R5J9	103..117		3/14 (21%)
		Targeting to endoplasmic reticulum membrane. /evidence=ECO:0000269\|PubMed:11096102	136..188		22/41 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343257
Domainoid	1	1.000	104	1.000	Domainoid score	I6555
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4673
Inparanoid	1	1.050	121	1.000	Inparanoid score	I4660
OMA	1	1.010	-	-		QHG49062
OrthoDB	1	1.010	-	-		D1288023at2759
OrthoFinder	1	1.000	-	-		FOG0003654
OrthoInspector	1	1.000	-	-		otm46087
orthoMCL	1	0.900	-	-		OOG6_105959
Panther	1	1.100	-	-	O	PTHR12859
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2527
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910