DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jwa and Arl6ip5

DIOPT Version :9

Sequence 1:	NP_609901.5	Gene:	Jwa / 35128	FlyBaseID:	FBgn0032704	Length:	249	Species:	Drosophila melanogaster
Sequence 2:	NP_075368.1	Gene:	Arl6ip5 / 65106	MGIID:	1929501	Length:	188	Species:	Mus musculus

Alignment Length:	194	Identity:	69/194 - (35%)
Similarity:	107/194 - (55%)	Gaps:	25/194 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 NLQLPPLRTLDDFILGSARFQLPNLKDFEKWGNRVVKNLLYYQTNYFLLFITIYVLMIFFNP-SK 123
            ::.|.|||..|||..||.||..|:.:|..||.||||.|||||||||.::...:..::.|.:| :.
Mouse     2 DVNLAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQTNYLVVAAMMISVVGFLSPFNM 66

  Fly   124 IITGLLVQALIIGVIWQFFS----GKSKKNFIASRLTGGNANAAEQNAQQKWYILAGALLGGYLL 184
            |:.|::|..:.:|.:|...:    .:.||.:..:                  :::. .:|..|.|
Mouse    67 ILGGVIVVLVFMGFVWAAHNKDILRRMKKQYPTA------------------FVMV-VMLASYFL 112

  Fly   185 LHLLSAVLLTIFTVLLPISLTFIHASLRLRNIKNKLTNSIESFA-PSTPMGSLLDALNVRAEGV 247
            :.:...|::.:|.:.||:.|.||||||||||:||||.|.:|... ..||||.:||||..:.:.:
Mouse   113 ISMFGGVMVFVFGITLPLLLMFIHASLRLRNLKNKLENKMEGIGLKKTPMGIILDALEQQEDNI 176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jwa	NP_609901.5	PRA1	62..220	CDD:281235	57/162 (35%)
Arl6ip5	NP_075368.1	PRA1	5..148	CDD:281235	57/161 (35%)
		Required for homodimer formation and heterodimer formation with ARL6IP1. /evidence=ECO:0000269\|PubMed:18684713	103..117		3/14 (21%)
		Targeting to endoplasmic reticulum membrane. /evidence=ECO:0000250\|UniProtKB:Q9ES40	136..188		22/41 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839440
Domainoid	1	1.000	106	1.000	Domainoid score	I6580
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4673
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4712
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49062
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003654
OrthoInspector	1	1.000	-	-		otm43998
orthoMCL	1	0.900	-	-		OOG6_105959
Panther	1	1.100	-	-	O	PTHR12859
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3380
SonicParanoid	1	1.000	-	-		X2527
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.930