DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jwa and PRAF2

DIOPT Version :9

Sequence 1:	NP_609901.5	Gene:	Jwa / 35128	FlyBaseID:	FBgn0032704	Length:	249	Species:	Drosophila melanogaster
Sequence 2:	NP_009144.1	Gene:	PRAF2 / 11230	HGNCID:	28911	Length:	178	Species:	Homo sapiens

Alignment Length:	194	Identity:	75/194 - (38%)
Similarity:	98/194 - (50%)	Gaps:	31/194 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LQLPPLRTLDDFILGSARFQLPNLKDFEKWGNRVVKNLLYYQTNYFLLFITIYVLMIFFNPSKII 125
            ::|||||.||||:|||||...|:..|.::|.:||:.|||||||||.|.|.....|..:..|...:
Human     4 VRLPPLRALDDFVLGSARLAAPDPCDPQRWCHRVINNLLYYQTNYLLCFGIGLALAGYVRPLHTL 68

  Fly   126 TGLLVQALIIGV-IWQFFSGKSKKNFIASRLTGGNANAAEQNA-------QQKWYILAGALLGGY 182
            ...||.|:.:|| :|                      |||..|       ......||..|..|.
Human    69 LSALVVAVALGVLVW----------------------AAETRAAVRRCRRSHPAACLAAVLAVGL 111

  Fly   183 LLLHLLSAVLLTIFTVLLPISLTFIHASLRLRNIKNKLTNSIESFA-PSTPMGSLLDALNVRAE 245
            |:|.:.......:|::..|:.|..:||||||||:|||:.|.|||.. ..||||.||:||....|
Human   112 LVLWVAGGACTFLFSIAGPVLLILVHASLRLRNLKNKIENKIESIGLKRTPMGLLLEALGQEQE 175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jwa	NP_609901.5	PRA1	62..220	CDD:281235	61/165 (37%)
PRAF2	NP_009144.1	PRA1	4..149	CDD:367393	61/166 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149382
Domainoid	1	1.000	102	1.000	Domainoid score	I6843
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	122	1.000	Inparanoid score	I4749
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49062
OrthoDB	1	1.010	-	-		D1288023at2759
OrthoFinder	1	1.000	-	-		FOG0003654
OrthoInspector	1	1.000	-	-		otm41949
orthoMCL	1	0.900	-	-		OOG6_105959
Panther	1	1.100	-	-	LDO	PTHR12859
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3380
SonicParanoid	1	1.000	-	-		X2527
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.940