DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10376 and PTC5

DIOPT Version :9

Sequence 1:	NP_609899.1	Gene:	CG10376 / 35126	FlyBaseID:	FBgn0032702	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_014733.1	Gene:	PTC5 / 854257	SGDID:	S000005616	Length:	572	Species:	Saccharomyces cerevisiae

Alignment Length:	514	Identity:	108/514 - (21%)
Similarity:	186/514 - (36%)	Gaps:	141/514 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LVSTAEKAAAVSEEVVSRSCVTRTANETYKVSGEERHAELVSAIWKQLETRGCPAQFRIKLLHRS 85
            ::|..:.....:::.:.|:..|..||.||    ..|....:|:..|.|..........:...:.|
Yeast    16 VLSKCQSGREYTQKFLQRAYSTSHANSTY----YSRTKLFISSHSKALNIALLSGSLLLTYSYYS 76

  Fly    86 TQQ-LEQDLCFAKECEVTVEGPPQYDL---------------LKLQKFVASEFEKYILKLTDNSE 134
            .:: |..|         |:.|...|..               .:.||...|:.::.:|.|.|:..
Yeast    77 PKKILSLD---------TINGIKDYSTNTSGNINMPSPNPKGTETQKSQRSQNDQSVLILNDSKI 132

  Fly   135 VDRLKDFADEAAPENCECHQQKEPLH------------TSAAVKNKPRKMED----RCVCLDRFG 183
            ..:|.|               :|..|            .:....|.|  :||    :.:.:....
Yeast   133 EAKLHD---------------REESHFVNRGTGIFRYDVAQLPSNHP--IEDDHVEQIITIPIES 180

  Fly   184 EMYELLDKTTRFFGVFDGHSGSLSATYATSQLPQLLADQLKA--NPDPAAFSPD---FYRNAFES 243
            |..:.::|...|||:||||.|..::...:..|.:.:|.||..  :.:...|..|   ...:|...
Yeast   181 EDGKSIEKDLYFFGIFDGHGGPFTSEKLSKDLVRYVAYQLGQVYDQNKTVFHSDPNQLIDSAISK 245

  Fly   244 AFLLAD-----ERFTQKKITSGTTSV----------CALI-----TKDQLYIAWVGDSKALLV-- 286
            .||..|     |.|.:.......|::          |||:     |...|.:|..|||:||:.
Yeast   246 GFLKLDNDLVIESFRKLFQDPNNTNIANTLPAISGSCALLSLYNSTNSILKVAVTGDSRALICGL 310

  Fly   287 ---GKRTQLQLVKPHKPENPDERKRI--ETAGGTVLHAQGQWRVNGILNVARSIGDYSLEA---- 342
               |..|...|......:|.||.:||  |..|...:...|  |:.|.|..:|:.|||..:.
Yeast   311 DNEGNWTVKSLSTDQTGDNLDEVRRIRKEHPGEPNVIRNG--RILGSLQPSRAFGDYRYKIKEVD 373

  Fly   343 ---------------------------VIAEPDFVDVQLNEAHDFLVLGTDGLWDHVPE----SL 376
                                       |.|||.....::.|...|:|:|:|||::.:..    ||
Yeast   374 GKPLSDLPEVAKLYFRREPRDFKTPPYVTAEPVITSAKIGENTKFMVMGSDGLFELLTNEEIASL 438

  Fly   377 IIETVYD--SLADTTMKLDDIPKLLIEAAKERDSQ-------DNITAVVVLLKPRHQIE 426
            :|..:..  :||....:...:|| :|:.::::::|       ||.::......|.:.||
Yeast   439 VIRWMDKNMNLAPVKAEPGKLPK-VIDVSEDKEAQRPAFRYKDNNSSSPSGSNPEYLIE 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10376	NP_609899.1	PP2Cc	160..419	CDD:238083	79/350 (23%)
PTC5	NP_014733.1	PP2C	182..464	CDD:395385	69/284 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X119
TreeFam	0	0.000	Not matched by this tool.
	2	1.900