DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10376 and PTC6

DIOPT Version :9

Sequence 1:	NP_609899.1	Gene:	CG10376 / 35126	FlyBaseID:	FBgn0032702	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_010003.2	Gene:	PTC6 / 850441	SGDID:	S000002133	Length:	442	Species:	Saccharomyces cerevisiae

Alignment Length:	397	Identity:	89/397 - (22%)
Similarity:	142/397 - (35%)	Gaps:	126/397 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 TQQLEQDLCFAKECEVTVEGP-PQYDLLKLQKFV----------------ASEFEKYILKLTDNS 133
            :|.|...||      .:::.| |.:|...|:|.|                .|.|||:..|...|
Yeast    78 SQLLADKLC------SSLDFPEPSWDKQDLKKLVQEYARRFPEGNYWKHKLSTFEKFYNKFIKN- 135

  Fly   134 EVDRLKDFADEAAPENCECHQQKEPL---HTSAAV--KNKPRKMEDRC-VCLDRFGEMYELLDKT 192
                              |:.::|.|   ...:|:  :|..|.:.|:. ..:|:...:.| ||:.
Yeast   136 ------------------CNSKQELLLMKEGDSAILGQNGGRMIFDKMGNIIDKIALLTE-LDRL 181

  Fly   193 TRFFGV--FDGHS----GSLSATYATSQLPQLLADQLKANPDPAAFSPDFYRNAFESAFLLADER 251
            ..|:|.  ||...    |:.:.:.|:|..       |....||.|  |             .||
Yeast   182 RLFYGFARFDLDQCCGLGTAAGSTASSIF-------LYPYDDPNA--P-------------IDE- 223

  Fly   252 FTQKKITSGTTSVCALITKDQLYIAWVGDSKALLVGK-RTQLQLVKPHKPENPDERKRIETAGGT 315
              .|...|...|...|:   :|.:..|||||.:|..: .....|...|...:..||.|:......
Yeast   224 --GKDDDSWIISHSGLL---KLIVTQVGDSKIILCDQDGIAHALTTTHHINSSRERHRLSIDPSR 283

  Fly   316 V-LHAQGQWR-VNGILNVARSIGDYSLE--AVIAEPDFVD----------------VQLNEAHDF 360
            : ..|.|:.| :|...| .||.||.:.:  .:.:|||...                :..|....|
Yeast   284 LDPDAFGETRFLNNFAN-TRSFGDVAGKPYGISSEPDIFSFLVGNTLHLPRSERSKLPFNGDECF 347

  Fly   361 LVLGTDGLWDHVPESLIIETVYDS-------------LADTTMKLDDIPKLLIEAAKERDSQDNI 412
            |.|.|||:.:.:.:..:::.:..:             :|:.|:|       .|:|...:.| ||.
Yeast   348 LALVTDGITNKLADQEVVDLITSTVNSWGLKKATPQFVAEETIK-------FIQAIATKHS-DNA 404

  Fly   413 TAVVVLL 419
            |.|||.|
Yeast   405 TCVVVRL 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10376	NP_609899.1	PP2Cc	160..419	CDD:238083	69/301 (23%)
PTC6	NP_010003.2	PP2C	108..401	CDD:395385	71/348 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343070
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13832
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930