DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10376 and PPM1D

DIOPT Version :9

Sequence 1:	NP_609899.1	Gene:	CG10376 / 35126	FlyBaseID:	FBgn0032702	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_003611.1	Gene:	PPM1D / 8493	HGNCID:	9277	Length:	605	Species:	Homo sapiens

Alignment Length:	321	Identity:	90/321 - (28%)
Similarity:	141/321 - (43%)	Gaps:	70/321 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 QQKEPLHTSAAVKNKPRKMEDRCVCLDRFGEMYELLDKTTRFFGVFDGHSGSLSATYATSQLPQL 218
            :.::||..:.|     .....|| |..|         .:..||.|.|||.|..:|.:|...|...
Human    74 EARDPLPDAGA-----SPAPSRC-CRRR---------SSVAFFAVCDGHGGREAAQFAREHLWGF 123

  Fly   219 LADQLK-ANPDPAAFSPDFYRNAFESAFL-----LAD--ERFTQKKITSGTTSVCALITKDQLYI 275
            :..|.. .:.:||...... |..|.:..|     ||:  :..|....|||||:...:|...::|:
Human   124 IKKQKGFTSSEPAKVCAAI-RKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYV 187

  Fly   276 AWVGDSKALLVGKRTQ--------LQLVKPHKPENPDERKRIETAGGTVLHAQGQWRV------- 325
            |.|||| .:::|.:..        :::.:.||||.|.||:|||..||:|::..|..||
Human   188 AHVGDS-GVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRL 251

  Fly   326 --NG------------ILNVARSIGD------YSLEAVIA-EPDFVDVQLN-EAHDFLVLGTDGL 368
              ||            .|.|||::||      :|.|.|:: |||.....|: :.|.:::||:|||
Human   252 THNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGL 316

  Fly   369 WDHVPESLIIETVYDSLADTTMKLD---DIPKLLIEAAKERDSQ-----DNITAVVVLLKP 421
            |:.:|....|....|......:..:   ...|:|:..|..|..|     ||.:|:|:.:.|
Human   317 WNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISP 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10376	NP_609899.1	PP2Cc	160..419	CDD:238083	87/311 (28%)
PPM1D	NP_003611.1	Interaction with CHEK1. /evidence=ECO:0000269\|PubMed:15870257	1..101		7/41 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..90		3/20 (15%)
		PP2C	67..368	CDD:278884	86/310 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..591
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810