DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10376 and ppm1e

DIOPT Version :9

Sequence 1:	NP_609899.1	Gene:	CG10376 / 35126	FlyBaseID:	FBgn0032702	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001018354.1	Gene:	ppm1e / 553417	ZFINID:	ZDB-GENE-070326-2	Length:	633	Species:	Danio rerio

Alignment Length:	432	Identity:	137/432 - (31%)
Similarity:	201/432 - (46%)	Gaps:	61/432 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FKRFL-VSTAEKAAAVSEEVVSRSCVTRTANETYKVSGEERHAELVSAIWKQLETRGCPAQFRIK 80
            ||||| :...|....:.|:|   ...||..::.  :|.:|...|.:....:.|....||......
Zfish    11 FKRFLELFLREMRPPIQEDV---PLPTRPLSDL--ISEDEVEGECLDLCLQHLCKYNCPFSLAAA 70

  Fly    81 LLHRSTQQ-LEQDLCF-----------AKECEVTVEGPPQYDLLKLQKFVASEFEKYILKLTDNS 133
            |...:... |:.||..           ..|.|...|...|.|.:||.:.|.:       ||.:..
Zfish    71 LARGTADSILQSDLSLYHLNKSVEDGTETETETETETQTQIDSVKLARLVFN-------KLCETC 128

  Fly   134 EVDRLKDFADEAAPENCECHQQKEPLHTSA--AVKNKPRKMEDRCVCLDRFGEMYELLDKTTR-F 195
            . ..||||         ...::..|.:.::  |:||..|||||:.|.:..|..::.|.|:..: :
Zfish   129 S-QWLKDF---------PYRRRHLPYYETSIHAIKNMRRKMEDKHVVIPDFNTLFNLQDQEEQAY 183

  Fly   196 FGVFDGHSGSLSATYATSQLPQLLADQLKANPDPAAFSPDFYRNAFESAFLLADERFTQK----K 256
            |.|||||.|..:|.||.:.|...|..|       ..||.| ...|...:|.|.||||.:|    .
Zfish   184 FAVFDGHGGVDAANYAANHLHVNLVRQ-------EMFSQD-AGEALCHSFKLTDERFIKKAKSEN 240

  Fly   257 ITSGTTSVCALITKDQLYIAWVGDSKALLVGKRTQLQLVKPHKPENPDERKRIETAGGTVLHAQG 321
            :..|||.|...:....||:.|:|||:.::|.:...::|:|||||:..||:||||..||.|:.. |
Zfish   241 LRCGTTGVVTFLRGRTLYVTWLGDSQVMMVKRGQPVELMKPHKPDREDEKKRIEALGGCVIWF-G 304

  Fly   322 QWRVNGILNVARSIGDYSLEAVI-AEPDFVDVQLNEAHDFLVLGTDGLWDHVPESLIIETVYDSL 385
            .|||||.|:|:|:|||...:..| .:.|.....|:.:.|:|:|..||.:|.|.....:..|.|.|
Zfish   305 TWRVNGSLSVSRAIGDSEHKPYICGDADCSTFNLDGSEDYLILACDGFYDTVNPEEAVRVVSDHL 369

  Fly   386 ----ADTTMKLDDIPKLLIEAAKERDSQDNITAVVVLLK-PR 422
                .||.|    :...|:.:|::..|.||||.:||.|: ||
Zfish   370 QENNGDTAM----VAHKLVASARDAGSSDNITVIVVFLRDPR 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10376	NP_609899.1	PP2Cc	160..419	CDD:238083	99/270 (37%)
ppm1e	NP_001018354.1	PP2Cc	145..403	CDD:238083	99/270 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577922
Domainoid	1	1.000	150	1.000	Domainoid score	I4352
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I4185
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1044139at2759
OrthoFinder	1	1.000	-	-		FOG0002007
OrthoInspector	1	1.000	-	-		otm24571
orthoMCL	1	0.900	-	-		OOG6_106247
Panther	1	1.100	-	-	O	PTHR13832
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R955
SonicParanoid	1	1.000	-	-		X119
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790