DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10376 and PPM1K

DIOPT Version :9

Sequence 1:	NP_609899.1	Gene:	CG10376 / 35126	FlyBaseID:	FBgn0032702	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_689755.3	Gene:	PPM1K / 152926	HGNCID:	25415	Length:	372	Species:	Homo sapiens

Alignment Length:	287	Identity:	92/287 - (32%)
Similarity:	139/287 - (48%)	Gaps:	52/287 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 ENCECHQQKEPLHTSAAVKNKPRKMEDRCVCLDRFGEMYELLDKTTRFFGVFDGHSGSLSATYAT 212
            ||..|          |:...|.::.|||.       :..:|.|:.. :|.|:|||.|..:|.:..
Human    93 ENVGC----------ASQIGKRKENEDRF-------DFAQLTDEVL-YFAVYDGHGGPAAADFCH 139

  Fly   213 SQLPQLLADQLKANPDPAAFSPDFYRNAFESAFLLADERFTQKK--------ITSGTTSVCALIT 269
            :.:.:.:.|.|....:        .......|||..|:.|:...        :|||||:..||:
Human   140 THMEKCIMDLLPKEKN--------LETLLTLAFLEIDKAFSSHARLSADATLLTSGTTATVALL- 195

  Fly   270 KD--QLYIAWVGDSKALLVGKRTQLQLVKPHKPENPDERKRIETAGGTVL-HAQGQWRVNGILNV 331
            :|  :|.:|.||||:|:|..|...::|...|.||..||::||:..||.|. ::.||..|||.|.:
Human   196 RDGIELVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWNSLGQPHVNGRLAM 260

  Fly   332 ARSIGDYSLE--AVIAEPDFVDVQLNEAHD-FLVLGTDGLWDHVPESLIIETV---YDSLADTTM 390
            .|||||..|:  .|||||:...::|:.|.| ||||.|||:...|....|.:.|   :|.
Human   261 TRSIGDLDLKTSGVIAEPETKRIKLHHADDSFLVLTTDGINFMVNSQEICDFVNQCHDP------ 319

  Fly   391 KLDDIPKLLIEAAKERDSQDNITAVVV 417
              ::....:.|.|.:..::||.|||||
Human   320 --NEAAHAVTEQAIQYGTEDNSTAVVV 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10376	NP_609899.1	PP2Cc	160..419	CDD:238083	89/275 (32%)
PPM1K	NP_689755.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..55
PPM1K	NP_689755.3	PP2Cc	95..346	CDD:238083	90/285 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144722
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1044139at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X119
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750