Protein Alignment CG10376 and PPM1K

DIOPT Version :10

• Sequence 1: NP_609899.1
• Gene: CG10376 / 35126
• FlyBaseID: FBgn0032702
• Length: 428
• Species: Drosophila melanogaster
• Sequence 2: NP_689755.3
• Gene: PPM1K / 152926
• HGNCID: 25415
• Length: 372
• Species: Homo sapiens
• Alignment Length: 287
• Identity: 92/287 - (32%)
• Similarity: 139/287 - (48%)
• Gaps: 52/287 - (18%)

  Fly   148 ENCECHQQKEPLHTSAAVKNKPRKMEDRCVCLDRFGEMYELLDKTTRFFGVFDGHSGSLSATYAT 212
            ||..|          |:...|.::.|||.       :..:|.|:.. :|.|:|||.|..:|.:..
Human    93 ENVGC----------ASQIGKRKENEDRF-------DFAQLTDEVL-YFAVYDGHGGPAAADFCH 139

  Fly   213 SQLPQLLADQLKANPDPAAFSPDFYRNAFESAFLLADERFTQKK--------ITSGTTSVCALIT 269
            :.:.:.:.|.|....:        .......|||..|:.|:...        :|||||:..||:
Human   140 THMEKCIMDLLPKEKN--------LETLLTLAFLEIDKAFSSHARLSADATLLTSGTTATVALL- 195

  Fly   270 KD--QLYIAWVGDSKALLVGKRTQLQLVKPHKPENPDERKRIETAGGTVL-HAQGQWRVNGILNV 331
            :|  :|.:|.||||:|:|..|...::|...|.||..||::||:..||.|. ::.||..|||.|.:
Human   196 RDGIELVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWNSLGQPHVNGRLAM 260

  Fly   332 ARSIGDYSLE--AVIAEPDFVDVQLNEAHD-FLVLGTDGLWDHVPESLIIETV---YDSLADTTM 390
            .|||||..|:  .|||||:...::|:.|.| ||||.|||:...|....|.:.|   :|.
Human   261 TRSIGDLDLKTSGVIAEPETKRIKLHHADDSFLVLTTDGINFMVNSQEICDFVNQCHDP------ 319

  Fly   391 KLDDIPKLLIEAAKERDSQDNITAVVV 417
              ::....:.|.|.:..::||.|||||
Human   320 --NEAAHAVTEQAIQYGTEDNSTAVVV 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10376	NP_609899.1	PP2Cc	160..419	CDD:238083	89/275 (32%)
PPM1K	NP_689755.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..55
		Critical for association with the BCKDH complex. /evidence=ECO:0000269|PubMed:22589535	46..61
		PP2Cc	95..346	CDD:238083	90/285 (32%)