DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10376 and PP2D1

DIOPT Version :9

Sequence 1:	NP_609899.1	Gene:	CG10376 / 35126	FlyBaseID:	FBgn0032702	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001239586.1	Gene:	PP2D1 / 151649	HGNCID:	28406	Length:	630	Species:	Homo sapiens

Alignment Length:	476	Identity:	97/476 - (20%)
Similarity:	163/476 - (34%)	Gaps:	152/476 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IPASECAHLMEFKRFLVSTAEKAAAVSEEVVSRSCVTRTANETYKVSGEERHAELVSAIWKQLET 70
            :|.|.|.|.::.....:...:..|              .|...::..|.::....|.|:.:
Human    64 LPCSICKHEIDLTGIFLHKKQHVA--------------LATLGFQWMGRKKPQPSVIAVQR---- 110

  Fly    71 RGCPAQFRIKLLHRS---TQQLEQDLCFAKECEVTVEGPPQYDLLKLQKFVASEFEKYILKLTDN 132
                 ||.|..|..|   |::..|.:..|.|.....:.|..|                  |:.||
Human   111 -----QFMISKLLSSFMFTEKTLQSINNAFELLWKKQIPAYY------------------KIFDN 152

  Fly   133 SEVDRLKDFADEAAPENCECHQQKEPLHTSAAV---KNKPRK--MEDRCVCLDRFGEMYELLDKT 192
              :||...::.:.      ||.    |.....:   :|...|  |.|:...:..||....:.
Human   153 --IDRSVIYSQKI------CHL----LIKGVGICEDRNSTWKADMNDKFTVVSNFGNKPNVC--- 202

  Fly   193 TRFFGVFDGHSGSLSATYATSQLPQLLADQL-KANP------DPAAFSPDFY------------- 237
              |||:||||.|:.:|...:.:||.||..|| |.:|      |.......||
Human   203 --FFGLFDGHHGASAAELTSMELPVLLLHQLSKFDPSYQMTTDEQQIINSFYTVFREEYAAIEDL 265

  Fly   238 -----------------RNAFESAFLLADE--RFTQKKIT----SGTTSV-CALITKDQ------ 272
                             ..||..||...|.  ...:|:::    ||.::| |.|..|.:
Human   266 FSAINKTEAVRCEYEDTHKAFAKAFWRMDRLLGLGRKEVSRVQWSGCSAVTCILEGKPKSPYAHK 330

  Fly   273 ---------------------------LYIAWVGDSKALLVGKRTQLQLVKPHKPENPDERKRIE 310
                                       |::|..|:.:|:|........|.|.|...|.:||:||.
Human   331 NWKRKNTHDGLAESSPSQEMPKIISGILHVANTGNVQAVLCRNGKGFCLTKEHTTRNTNERRRIL 395

  Fly   311 TAGGTVLHAQGQWRVNGILNVARSIGDYS----LEAVIAEPDFVDVQLNEAHDFLVLGTDGLWDH 371
            ..|..:...:....|.|.:...|.:|.:.    .:::|..|..:.|.:::...||::.|:|||:.
Human   396 QNGAVISSNEPYGLVEGQVKTTRGLGFHGNLKLKKSIIPAPQTISVPIDDLCQFLIVATNGLWEV 460

  Fly   372 VPESLIIETVYDSLADTTMKL 392
            :.:..:     .:||.||..:
Human   461 LDKEEV-----TALAMTTFHM 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10376	NP_609899.1	PP2Cc	160..419	CDD:238083	69/319 (22%)
PP2D1	NP_001239586.1	PP2Cc	181..466	CDD:238083	64/289 (22%)
PP2D1	NP_001239586.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	557..578
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144729
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740