DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10376 and TAB1

DIOPT Version :9

Sequence 1:	NP_609899.1	Gene:	CG10376 / 35126	FlyBaseID:	FBgn0032702	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_006107.1	Gene:	TAB1 / 10454	HGNCID:	18157	Length:	504	Species:	Homo sapiens

Alignment Length:	305	Identity:	78/305 - (25%)
Similarity:	124/305 - (40%)	Gaps:	89/305 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 FGVFDGHSGSLSATYATSQL-PQLLADQLKANPDPAAFSPDFYR---NAF---ESAFL------L 247
            :|||:|:.|:....:...:| .:||..||.|....|    |..|   .||   |.:||      |
Human    65 YGVFNGYDGNRVTNFVAQRLSAELLLGQLNAEHAEA----DVRRVLLQAFDVVERSFLESIDDAL 125

  Fly   248 ADE---------------------------RFTQKKITSGTTSVCALITKDQLYIAWVGDSKALL 285
            |::                           :..:::|:.|..:|.|::..::||:|.||.::|||
Human   126 AEKASLQSQLPEGVPQHQLPPQYQKILERLKTLEREISGGAMAVVAVLLNNKLYVANVGTNRALL 190

  Fly   286 VGKR------TQLQLVKPHKPENPDERKRIETAGGTVLHAQGQWRVNGIL---NVARSIGDYSL- 340
            ....      |||.:  .|..||.||..|:...|   |.| |:.:..||:   ...|.||||.:
Human   191 CKSTVDGLQVTQLNV--DHTTENEDELFRLSQLG---LDA-GKIKQVGIICGQESTRRIGDYKVK 249

  Fly   341 --------------EAVIAEPDFVDVQ-LNEAHDFLVLGTDGLWD-----HVPESLIIETVYDSL 385
                          :.:||||:....| |:....||||.::||:.     |.|.....|..  ::
Human   250 YGYTDIDLLSAAKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAHGPGQANQEIA--AM 312

  Fly   386 ADTTM----KLDDIPKLLIEAAKERDSQDNITAVVVLLK--PRHQ 424
            .||..    .||.:.:.:::..| |...|...:.....:  |||:
Human   313 IDTEFAKQTSLDAVAQAVVDRVK-RIHSDTFASGGERARFCPRHE 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10376	NP_609899.1	PP2Cc	160..419	CDD:238083	75/296 (25%)
TAB1	NP_006107.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		PP2C	69..334	CDD:395385	69/276 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..478
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810