DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10341 and naf1

DIOPT Version :9

Sequence 1:	NP_609898.1	Gene:	CG10341 / 35125	FlyBaseID:	FBgn0032701	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_021330896.1	Gene:	naf1 / 568328	ZFINID:	ZDB-GENE-030131-4546	Length:	503	Species:	Danio rerio

Alignment Length:	584	Identity:	176/584 - (30%)
Similarity:	268/584 - (45%)	Gaps:	133/584 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 TETAVELGKHSTLKADLSIDKLETATTEATNAVVEPVEMEQQVENE--LVNESTQAMTSTTTQEK 83
            |...:.:...||..|..|.|:.||.:.:      :.:|::.:.||.  |:..:.:..||....::
Zfish     4 THGELNMENSSTENATYSQDQDETKSKK------DEMELDIKTENTDVLIGPTDEPCTSEQRDDQ 62

  Fly    84 V------VGSVNNLVEEQQCVEMEFETSSDLVVQGSPSEESKKVA--SDASATVTAPQVQPAPHV 140
            :      ..|..|  .|.|.|:.|..||....:.|.......:.|  .||..:..:.:...:.::
Zfish    63 ISSIQPEQSSKEN--SEHQLVKEEDFTSDHAGLTGEDQSSGGQPALIRDALTSDQSGRADQSSNI 125

  Fly   141 DSSPQASGLSLLAAYSSDDSDDEKVTPVQNGDNDVIEVPVTDPASSTTA-------YRPVVAVSS 198
            .|.|                .||::..||:|..::....|..|.|.|.:       ||   ..||
Zfish   126 KSEP----------------IDEQICSVQSGPAEMQYGTVVSPQSGTGSLALLSMQYR---GNSS 171

  Fly   199 DD---------ESSKSSSSSSDSDSDSEGEYLTVLRKKIDKRINTVDCDEDDEDFDEDGATGDRS 254
            ||         .||.||||||.|.|.||...:.::..|.          |||:| ||..|.|  :
Zfish   172 DDNCSDSDSDSSSSTSSSSSSSSSSSSEPFEVVIMPNKA----------EDDDD-DEGFAGG--N 223

  Fly   255 RRRQPPKVRGEMLLDDLPPIHQLEITVPED-ECVELGKVQSIVDQLVLVSVLPNSMLFDLDTVLF 318
            ::..|.|.:.|:|:||||.:..|.|::||| |...:|.:.|||||||:|....|....:.::|||
Zfish   224 KKSAPVKTQDELLIDDLPAVENLIISLPEDTEMEPIGTISSIVDQLVIVESYKNLPPLNEESVLF 288

  Fly   319 LEKGRKVLGEVFDVLGQVSDPLYCVRFNSNKQILDRGIKIGDVVYCAPK-TEHTQFVILSKLMQV 382
             .|.|..:|:||::.|.|..|.|.:||||:..|..:.:|:.|.||.||| .:.|.::...||..:
Zfish   289 -SKNRNSVGKVFEIFGPVCQPFYVLRFNSHDDIEQKDLKVRDPVYFAPKLKDFTDYIFTDKLKTL 352

  Fly   383 RGSDASWEHDVEPPARYVDHSDDEEEREA--RAEQRKRRQRDRTNSTDSVDTVTSVATTATKASS 445
            :||||||::|.|||...:|.||||:||.|  :.:::||||::.::|.|..|        |.|.
Zfish   353 KGSDASWKNDQEPPPEALDFSDDEQERLAKQKLKEQKRRQQNDSDSEDESD--------AQKM-- 407

  Fly   446 VAPPPRQRGRRGQRESFRQSQRPSINQHNQNQPQDEQYNFHPSYNPGSWHSNYYQNYHQAAANFN 510
                |::..||..|:             |:|.|:.:.:|     ..|.:|||::
Zfish   408 ----PQKAARRKPRQ-------------NRNHPRGQYHN-----RGGGFHSNFH----------- 439

  Fly   511 MAQQHPGMPFPVPNYGYGMPYAMPPMYPHM------YPPPPPF----AP-PPPNNQSHQGQPPP 563
               .||..|   |.  |.:|:..|.|:|:.      :|.|.|:    || ||..||....||||
Zfish   440 ---AHPRFP---PE--YMLPHPDPQMFPYQGPMVPHFPRPSPYHMGMAPWPPGPNQGFMFQPPP 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10341	NP_609898.1	Gar1	269..403	CDD:282290	58/135 (43%)
naf1	XP_021330896.1	Gar1	238..389	CDD:309520	65/151 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595945
Domainoid	1	1.000	123	1.000	Domainoid score	I5551
eggNOG	1	0.900	-	-		E1_KOG2236
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	190	1.000	Inparanoid score	I3870
OMA	1	1.010	-	-		QHG58281
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003330
OrthoInspector	1	1.000	-	-		oto39570
orthoMCL	1	0.900	-	-		OOG6_104062
Panther	1	1.100	-	-	LDO	PTHR31633
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R792
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790