DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10383 and serac1

DIOPT Version :9

Sequence 1:	NP_001286055.1	Gene:	CG10383 / 35123	FlyBaseID:	FBgn0032699	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_005160640.1	Gene:	serac1 / 568022	ZFINID:	ZDB-GENE-040616-1	Length:	658	Species:	Danio rerio

Alignment Length:	779	Identity:	204/779 - (26%)
Similarity:	334/779 - (42%)	Gaps:	204/779 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LRRHPKLLG---LGGVGLITAAGFLLYESPQVRRFLSQYVDKKSPEPDKRRAEYIYIKYHIYRE- 70
            :||..|:.|   .||...||      ||...:.:.|:  :|..:...:|::: |||..:...||
Zfish    30 IRRIAKVTGAIVFGGCVFIT------YEVVTLNQALT--IDTSAILQEKQKS-YIYPTHSTNREQ 85

  Fly    71 -------SMRKLKQKEEDEKKWIS----VIINPIGKWWK---AAKHSVA-WRLLNIAQTGSQPER 120
                   :::..::..:..:|::.    |:.:|:.:...   |..|..| |.||..:::..:..|
Zfish    86 ESLASGLTIKTRRELHKAARKFLEITSRVLHHPLDEHLSHLDADPHECALWVLLKRSRSADRAVR 150

  Fly   121 LKAVQQLICMDHLKDWDFRHLAQICDARTAVSLARC-NADTRWFMPVPRRGCIKNPKMLLSELHV 184
            ..|||:|....|.:|:.::..||:.|.||||:|||. |.|.|:|:|.|.....::...:...|..
Zfish   151 HLAVQELAHNHHWRDYQYQTAAQVVDQRTAVALARIPNVDLRFFLPPPPLPHTEDDISIEDGLRQ 215

  Fly   185 MLARLRPMA----CIDHFFSKYFPEQD---------------------------PIEDIHEYLTQ 218
            :||.| |.:    |:.:|.|....|..                           |.|.:..:..
Zfish   216 LLASL-PQSDVDQCVQYFTSLALRESSQSLASQRGGLWCFGGNGLPYAQSLTSTPSEKVETFCL- 278

  Fly   219 EQTIVLSTADTDLLKEIISFLHHITKDPEVSARLMRDGGLVHLMELRKIFNDDNETLSTLCKVLA 283
             |.:|..:       ::.|...||          :.:|||..|..:.::..|..:....:.:::.
Zfish   279 -QALVQHS-------KVRSHCEHI----------VANGGLQLLQRVYQLRRDSPKIQRNIVRIIG 325

  Fly   284 NMSLVPDAVEHFFTSGWVGALAEWQQCPDLRLQVISAKTMANLDHDDPNQCTYPPNVYPLHPRVR 348
            |::|..:.......|||:..|||..|.|.:.....:|:.:||||.|...| .|...||.|||:.|
Zfish   326 NLALNENLHTTIVQSGWMSVLAEMIQSPHIMQASHAARALANLDRDAVRQ-KYQDGVYILHPQCR 389

  Fly   349 TRRKPKADIVFVHGLLGGVFITWRQRDRKPTELGLYGKNAFYTSETDDVFLVGEQKRLSGGKLKP 413
            |.:..|||::|||||||..|.||||:|               ...|||
Zfish   390 TNQPIKADVLFVHGLLGAAFKTWRQKD---------------CDVTDD----------------- 422

  Fly   414 GEAVKNVNGNQKTETIKDPVLKASKKVEEQRLNISDAATKEFVETLRNEAELDSDWEVVHPDVPL 478

Zfish   423 ----------------------------------------------------------------- 422

  Fly   479 NANEECEGKFSVCGSEWRNQDTSEEYTNCWPMEWLPDDYPDSRILGIDYTSAVTEWSANFTKYCP 543
               |:.||             ..|:||.|||..||..|.|:.|||.::|.:.:::|::.    ||
Zfish   423 ---EKLEG-------------VREDYTECWPKSWLAADCPNLRILSVEYDTHLSDWNSK----CP 467

  Fly   544 CEKGQGHIDVRANTLLDRISASDVGNDRPIVWIGHSMGGLLTKLILLKSLDSQEPKVQQLTKNTK 608
            .|..:..:..|:..||.::..:.|| :||::|:.|||||||.|.:||.:  :::|.:..|.||||
Zfish   468 VENQRKSLAFRSQELLRKLKDAGVG-ERPVIWVAHSMGGLLVKKMLLDA--AKDPDLSSLIKNTK 529

  Fly   609 GIVFLGTPHRGSPIAKWKQHMQMILSPSIEVKEMEENSPKLLEMHRRFMGCLHTLLRHVKVVSVA 673
            ||:|...||.|:.:|::...::.:|.|||||||:..:||.|.:::..|:.....  |..||:|.|
Zfish   530 GILFYSVPHHGTFMAEYSVSVRYLLFPSIEVKELCRDSPALRDLNENFLNIAKD--REFKVLSFA 592

  Fly   674 EGSPTMLTSFKFPLRIVTEESSKIDFGDFYLLKDDHLSLSKPIYRQSFLYQRLLHVIREAIKER 737
            |..||.:... ..:.:|...|:.:..||...:..|||::.||..:.:|||:|.|..|::|:..|
Zfish   593 ETVPTYIGPM-LKILVVPAHSADLGIGDLIQVDVDHLNICKPEKKDTFLYKRTLQFIQDALGGR 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10383	NP_001286055.1	Abhydrolase	<522..>642	CDD:304388	45/119 (38%)
serac1	XP_005160640.1	armadillo repeat	259..287	CDD:293788	4/36 (11%)
		armadillo repeat	294..329	CDD:293788	7/44 (16%)
		armadillo repeat	335..368	CDD:293788	10/32 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41900
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47771
OrthoDB	1	1.010	-	-		D1311762at2759
OrthoFinder	1	1.000	-	-		FOG0005732
OrthoInspector	1	1.000	-	-		oto40875
orthoMCL	1	0.900	-	-		OOG6_104869
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3155
SonicParanoid	1	1.000	-	-		X4128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.720