DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10383 and serac1

DIOPT Version :9

Sequence 1:	NP_001286055.1	Gene:	CG10383 / 35123	FlyBaseID:	FBgn0032699	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_031758164.1	Gene:	serac1 / 101730273	XenbaseID:	XB-GENE-6041738	Length:	657	Species:	Xenopus tropicalis

Alignment Length:	767	Identity:	206/767 - (26%)
Similarity:	326/767 - (42%)	Gaps:	205/767 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LGLGGVGLITAAGFLLYESPQVRRFLSQ--------------YVDKKSPE-------PDKRRAEY 60
            |.|||...||      ||...:::.||.              |||..|.|       .||.|.|.
Frog    40 LFLGGCVFIT------YEILSLKKSLSLNTQAAQQEKLKSYIYVDTSSIEQSDFQGISDKVRREL 98

  Fly    61 IYIKYHIYRESMRKLKQKEEDEKKWISVIINPIGKWWKAAKHSVAWRLLNIAQTGSQPERLKAVQ 125
            .......:..|.|..::..:.|:..:|.:.:  .:|       |.|.|:..||:..:..|||||:
Frog    99 HRTARRAFEASARLFRRPHDKEQYSLSSMED--HEW-------VQWVLMKNAQSQDRTVRLKAVE 154

  Fly   126 QLICMDHLKDWDFRHLAQICDARTAVSLARC-NADTRWFMPVPRRGCIKNPKMLLSELHVMLARL 189
            ::..:.|..|:.:|.:||.||.||.|.|||. |.|.|:|:|.|....:.:...:...|..:|:.|
Frog   155 EMAGIHHWHDYQYRTVAQACDKRTTVGLARSKNTDLRFFLPPPALPKVDDNYSIEYGLRQLLSSL 219

  Fly   190 RPMACIDHFFSKYFPEQDPIEDIHEYLT------QEQTIV-------------------LSTADT 229
                           .|..::...:|||      ..|:|.                   ||:..:
Frog   220 ---------------PQTELDQCVKYLTSLALRESSQSIADQRRGLWCFGGNGLPYAESLSSVPS 269

  Fly   230 DL--LKEIISFLHHITKDPEVSARLMRDGGLVHLMELRKIFNDDNETLSTLCKVLANMSLVPDAV 292
            :.  |..:.:.|.| :|.|....:::..|||..|..:..:..|..:...|:.:::.|::|..:..
Frog   270 EKVELSSLQALLKH-SKIPTHCVKIVSGGGLQLLQRIYLLRKDAQKIQRTIVRIIGNLALHENLH 333

  Fly   293 EHFFTSGWVGALAEWQQCPDLRLQVISAKTMANLDHDDPNQCTYPPNVYPLHPRVRTRRKPKADI 357
            .....|||:..|||..:.|.:.....:|:.:||||.|..|: .||..:|.|||:.|:.:..:|||
Frog   334 SEIVDSGWIPILAEAMKSPYVIQSSHAARVLANLDRDSVNE-KYPDGIYVLHPQYRSSQPIRADI 397

  Fly   358 VFVHGLLGGVFITWRQRDRKPTELGLYGKNAFYTSETDDVFLVGEQKRLSGGKLKPGEAVKNVNG 422
            :|:|||||..|.||||:||
Frog   398 LFIHGLLGAAFKTWRQQDR---------------------------------------------- 416

  Fly   423 NQKTETIKDPVLKASKKVEEQRLNISDAATKEFVETLRNEAELDSDWEVVHPDVPLNANEECEGK 487
                                                                |.||:.:...|
Frog   417 ----------------------------------------------------DEPLDESAALE-- 427

  Fly   488 FSVCGSEWRNQDTSEEYTNCWPMEWLPDDYPDSRILGIDYTSAVTEWSANFTKYCPCEKGQGHID 552
                          ::||.|||..||..|.||.|||.|:|.:.:::|.|.    ||.:..:..:|
Frog   428 --------------DDYTECWPKSWLATDSPDLRILSIEYDTQLSDWKAR----CPADNNRKSLD 474

  Fly   553 VRANTLLDRISASDVGNDRPIVWIGHSMGGLLTKLILLKSLDSQEPKVQQLTKNTKGIVFLGTPH 617
            .|:..||.::.|:.|| :|||:|:.|||||||.|.:|||:  ||:..::.|..||||:.|...||
Frog   475 YRSRNLLKKLKAAGVG-ERPIIWVSHSMGGLLVKKMLLKA--SQDEDMKDLVNNTKGVAFYSVPH 536

  Fly   618 RGSPIAKWKQHMQMILSPSIEVKEMEENSPKLLEMHRRFMGCLHTLLRHVKVVSVAEGSPTMLTS 682
            .||.:|::....:::|.|||||||:..:||:|.:::..|:  ..:..:..|::|.||..||.:..
Frog   537 HGSQLAEYSISARLLLFPSIEVKELSTDSPELKKLNDEFL--QFSKNKDFKIISFAELLPTRVGR 599

  Fly   683 FKFPLRIVTEESSKIDFGDFYLLKDDHLSLSKPIYRQSFLYQRLLHVIREAI 734
            . ..|.||..||:.:..|....:..:||::.||..:.||:||..|..|.:.:
Frog   600 M-MKLHIVPLESADLGIGKLIPVDVNHLNICKPKSKDSFIYQCTLQFIHDVL 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10383	NP_001286055.1	Abhydrolase	<522..>642	CDD:304388	50/119 (42%)
serac1	XP_031758164.1	armadillo repeat	258..283	CDD:293788	4/24 (17%)
		armadillo repeat	291..328	CDD:293788	7/36 (19%)
		armadillo repeat	334..367	CDD:293788	9/32 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	301	1.000	Domainoid score	I1399
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41900
Inparanoid	1	1.050	302	1.000	Inparanoid score	I2631
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1311762at2759
OrthoFinder	1	1.000	-	-		FOG0005732
OrthoInspector	1	1.000	-	-		oto105177
Panther	1	1.100	-	-	LDO	PTHR48187
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160