DRSC/TRiP Functional Genomics Resources

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Protein Alignment msl-1 and MSL1

DIOPT Version :10

Sequence 1:NP_476896.1 Gene:msl-1 / 35121 FlyBaseID:FBgn0005617 Length:1039 Species:Drosophila melanogaster
Sequence 2:NP_001352848.1 Gene:MSL1 / 339287 HGNCID:27905 Length:614 Species:Homo sapiens


Alignment Length:483 Identity:109/483 - (22%)
Similarity:190/483 - (39%) Gaps:123/483 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   565 PEDAPKHLPKAVAPKVTK----------TSSRESTL-------PKANTADIKDAPAQKVIANHQS 612
            |...|...|..:||..|.          .|.|:|.|       ..:..|.:|           |.
Human   172 PPPLPLPGPPPLAPTATAGTLAASEGRWKSMRKSPLGGGGGSGASSQAACLK-----------QI 225

  Fly   613 TKTQTDPVKTQRLQVKIRQYEMHPDMRTGSSAPSDIRKQKNVDPVSTPETKTIKSKSMLV--NDK 675
            ...|.|.::.|:.|::.::.|              |.:.|:.........:.::.:..||  :::
Human   226 LLLQLDLIEQQQQQLQAKEKE--------------IEELKSERDTLLARIERMERRMQLVKKDNE 276

  Fly   676 KTTSETSQSPDQEIDVETVRRKLAEHLKKELLSQSHSSQVTLKKIRERVATNLIYPPP------- 733
            |...:..|..:.|...||   :|:|.:|.|...:...:..||.            |.|       
Human   277 KERHKLFQGYETEEREET---ELSEKIKLECQPELSETSQTLP------------PKPFSCGRSG 326

  Fly   734 -----SAPVSST-TITP----APTPSTTPTPGSTPQHAVTSSMDQEISAAKSKSKAAEQI---AT 785
                 .:|..|| ..||    ||..|...|  .||:|   |.:.:|...:.|::....::   .|
Human   327 KGHKRKSPFGSTERKTPVKKLAPEFSKVKT--KTPKH---SPIKEEPCGSLSETVCKRELRSQET 386

  Fly   786 PLTPQSNSSVSSTTSTIRKTLNNCSPHTYSKATARSGKLQSRFRTATFPYSTRTWEDQEFHC--- 847
            |..|:|:.......||.:|     .|.|:.|..|.|.:::.      .||.:.|   :.:.|   
Human   387 PEKPRSSVDTPPRLSTPQK-----GPSTHPKEKAFSSEIED------LPYLSTT---EMYLCRWH 437

  Fly   848 ---DNEFFLEEA----DELLA----------DNPSLEIPKWRDVPVPPSSDKIDTEL---LSDAT 892
               .:...|.|:    :|.:|          :...|.:|.|||..|.|..|...::|   |.|:.
Human   438 QPPPSPLPLRESSPKKEETVARCLMPSSVAGETSVLAVPSWRDHSVEPLRDPNPSDLLENLDDSV 502

  Fly   893 FERRHQKYVKDEVDRKCRDARYMKEQIRLEQLRMRRNQDEVLVALDPLRASTFYPLPEDIEAIQF 957
            |.:||.|...||..||..|.:.::||..|::|::|..:.:.:...:| ..::|:|.|:|:|::..
Human   503 FSKRHAKLELDEKRRKRWDIQRIREQRILQRLQLRMYKKKGIQESEP-EVTSFFPEPDDVESLMI 566

  Fly   958 VNEVTVQAFGENVVNMEARDDFGVPWVD 985
            ...:.|.|||..:..:..: :|.:||:|
Human   567 TPFLPVVAFGRPLPKLTPQ-NFELPWLD 593

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
msl-1NP_476896.1 PspC_subgroup_1 <447..>583 CDD:468201 6/27 (22%)
PEHE 866..983 CDD:464607 36/119 (30%)
MSL1NP_001352848.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..127
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 147..217 10/44 (23%)
Interaction with MSL2 223..237 4/24 (17%)
PTZ00108 <243..429 CDD:240271 47/230 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 272..420 40/172 (23%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q6PDM1 317..346 7/28 (25%)
PEHE 473..600 CDD:464607 39/123 (32%)
Interaction with KAT8 HAT domain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01397 496..514 6/17 (35%)
Bipartite nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q6PDM1 505..519 6/13 (46%)
Sufficient for interaction with MSL3 MRG domain 550..591 10/41 (24%)
Blue background indicates that the domain is not in the aligned region.

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