DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tos and EXO1

DIOPT Version :9

Sequence 1:	NP_477145.1	Gene:	tos / 35119	FlyBaseID:	FBgn0015553	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_006018.4	Gene:	EXO1 / 9156	HGNCID:	3511	Length:	846	Species:	Homo sapiens

Alignment Length:	794	Identity:	272/794 - (34%)
Similarity:	395/794 - (49%)	Gaps:	124/794 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGITGLIPFVGKASSQLHLKDIRGSTVAVDTYCWLHKGVFGCAEKLARGEDTDVYIQYCLKYVNM 65
            |||.||:.|:.:||..:|::..:|..||||||||||||...||||||:||.||.|:.:|:|:|||
Human     1 MGIQGLLQFIKEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAEKLAKGEPTDRYVGFCMKFVNM 65

  Fly    66 LLSYDIKPILVFDGQHLPAKALTEKRRRDSRKQSKERAAELLRLGRIEEARSHMRRCVDVTHDMA 130
            |||:.|||||||||..||:|...|:.||:.|:.:..:..:|||.|::.|||....|.:::||.||
Human    66 LLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQLLREGKVSEARECFTRSINITHAMA 130

  Fly   131 LRLIRECRSRNVDCIVAPYEADAQMAWLNRADVAQYIITEDSDLTLFGAKNIIFKLDLNGSGLLV 195
            .::|:..||:.|||:|||||||||:|:||:|.:.|.||||||||..||.|.:|.|:|..|:||.:
Human   131 HKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQAIITEDSDLLAFGCKKVILKMDQFGNGLEI 195

  Fly   196 EAEKLHLAMGCTE--EKYHFDKFRRMCILSGCDYLDSLPGIGLAKACKFILKTEQEDMRIALKKI 258
            :..:|.:   |.:  :.:..:|||.||||||||||.||.|||||||||.:......|:...:|||
Human   196 DQARLGM---CRQLGDVFTEEKFRYMCILSGCDYLSSLRGIGLAKACKVLRLANNPDIVKVIKKI 257

  Fly   259 PSYLNMRNLEVDDDYIENFMKAEATFRHMFIYNPLERRMQRLCALEDYETDERYCSNAGTLLEDS 323
            ..||.| |:.|.:|||..|::|..||.:..:::|::|::..|.|.|| :.|....|.||..::||
Human   258 GHYLKM-NITVPEDYINGFIRANNTFLYQLVFDPIKRKLIPLNAYED-DVDPETLSYAGQYVDDS 320

  Fly   324 EQALHLALGNLNPFSMKRLDSWTPEKAWPT--------PKNVKRSKH-KSIWQTNFQSEN----- 374
             .||.:||||.:..:.:::|.:.|:.|.|.        .|..::|.: .|||..|:....
Human   321 -IALQIALGNKDINTFEQIDDYNPDTAMPAHSRSHSWDDKTCQKSANVSSIWHRNYSPRPESGTV 384

  Fly   375 THTPK-KENPCALFFKKV-DFVGKTLNEEIEANQRLEQAKQTEAELFNMYSF----KAKRRRS-- 431
            :..|: ||||..:..::| ...|..|..:....:|...|:.:|.:|.:.||.    |.|:..|
Human   385 SDAPQLKENPSTVGVERVISTKGLNLPRKSSIVKRPRSAELSEDDLLSQYSLSFTKKTKKNSSEG 449

  Fly   432 -----------------PSREDSVDQERTPPPSPVHKSRHNPFAK--ERTGEEA------NQRSP 471
                             |:.:.||.   |||.:      .|.||.  :|..||:      ..||.
Human   450 NKSLSFSEVFVPDLVNGPTNKKSVS---TPPRT------RNKFATFLQRKNEESGAVVVPGTRSR 505

  Fly   472 VVCENASLLRLLSPKKASPLDGEAGVKKVDSLKRSIFAKEQVQIRSRFFAT------QDE--QTR 528
            ..|.:.|...:.:.....|||..|...|.::|..|.:..::   ..|...|      .|:  ...
Human   506 FFCSSDSTDCVSNKVSIQPLDETAVTDKENNLHESEYGDQE---GKRLVDTDVARNSSDDIPNNH 567

  Fly   529 LQREHLRDTENDDMDEQKLSSHSGHKKLRLVCKDIPGKNPIRQRCSSQISDGETDTDTTASSLLE 593
            :..:|:.|......||:..|..|. |..|.:..  |....:|. |.|. |.|..|...|.|
Human   568 IPGDHIPDKATVFTDEESYSFESS-KFTRTISP--PTLGTLRS-CFSW-SGGLGDFSRTPS---- 623

  Fly   594 SQDKGVPSPLESQEDLNNSQPQIPTEGNTNSTTIRIKSLDLLLENSPEPTQESDRNNNDAIILLS 658
                  |||                     ||     :|......|..||...:.|.:|...|.|
Human   624 ------PSP---------------------ST-----ALQQFRRKSDSPTSLPENNMSDVSQLKS 656

  Fly   659 DDSCSSDQ----RASSTSSSSQQRQNFLPTSKRRVGLSKPSTAKKGTPKSRTNGKLGAVSQNQT- 718
            ::| |.|:    |..:.||.||:...|...|.....||:.|:....:.:|..|.||.....:||
Human   657 EES-SDDESHPLREEACSSQSQESGEFSLQSSNASKLSQCSSKDSDSEESDCNIKLLDSQSDQTS 720

  Fly   719 --KLSMFGFQTKPV 730
              :||.|..:..|:
Human   721 KLRLSHFSKKDTPL 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tos	NP_477145.1	PIN_EXO1	1..204	CDD:189027	107/202 (53%)
tos	NP_477145.1	H3TH_EXO1	214..291	CDD:188628	40/76 (53%)
EXO1	NP_006018.4	fen_arch	1..308	CDD:274717	155/311 (50%)
		PIN_EXO1	1..206	CDD:189027	108/207 (52%)
		N-domain	1..99		57/97 (59%)
		Interaction with MSH3. /evidence=ECO:0000269\|PubMed:11427529	129..387		109/263 (41%)
		I-domain	138..229		51/93 (55%)
		H3TH_EXO1	213..289	CDD:188628	40/76 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..396		6/23 (26%)
		Interaction with MLH1	388..490		26/110 (24%)
		Nuclear localization signal	418..421		1/2 (50%)
		Interaction with MSH2	600..846		45/174 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..781		38/154 (25%)
		Interaction with MLH1	787..846
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154011
Domainoid	1	1.000	127	1.000	Domainoid score	I5385
eggNOG	1	0.900	-	-		E1_COG0258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	347	1.000	Inparanoid score	I2307
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D468757at33208
OrthoFinder	1	1.000	-	-		FOG0003113
OrthoInspector	1	1.000	-	-		oto91536
orthoMCL	1	0.900	-	-		OOG6_101671
Panther	1	1.100	-	-	LDO	PTHR11081
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2084
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.760