Protein Alignment tos and YEN1

DIOPT Version :10

• Sequence 1: NP_477145.1
• Gene: tos / 35119
• FlyBaseID: FBgn0015553
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_010959.2
• Gene: YEN1 / 856764
• SGDID: S000000843
• Length: 759
• Species: Saccharomyces cerevisiae
• Alignment Length: 839
• Identity: 155/839 - (18%)
• Similarity: 275/839 - (32%)
• Gaps: 305/839 - (36%)

  Fly    23 RGSTVAVDTYCWLHKGVFGCA------------------EKLARGEDTDVYIQY----------- 58
            |...:|:|.|.||    |.|.                  .:..|..|.|...:|
Yeast    34 RAPRIAIDAYGWL----FECGFIQNIDISARSRSRSRSPTRSPRDSDIDSSQEYYGSRSYTTTGK 94

  Fly    59 -CLKYVNM---LLSYDIKPILVFDGQHLPA--KALTEKRRRDSRKQSKERAAELLRLGRIEEARS 117
             .:.:::.   |||.:::.:|||||...|:  :....::...:....||..:...:..:..|...
Yeast    95 AVINFISRLKELLSLNVEFLLVFDGVMKPSFKRKFNHEQNATTCDDEKEYYSSWEQHVKNHEVYG 159

  Fly   118 HMRRCVDVTHDMALRLIRECRS-RNVDCIVAPYEADAQMAWLNRADVAQYIITEDSDLTLFGAKN 181
            :.:..:..:....:.|:|:... .|:..::|..|.:||..||..:....:|::.|||..:||.:.
Yeast   160 NCKGLLAPSDPEFISLVRKLLDLMNISYVIACGEGEAQCVWLQVSGAVDFILSNDSDTLVFGGEK 224

  Fly   182 II-----FKLDLNGSGL-----------------LVEAEKLHLAMGCTEEKYHFDKFRRM----- 219
            |:     |..|...|.:                 :::..|::...|        .||.|:
Yeast   225 ILKNYSKFYDDFGPSSITSHSPSRHHDSKESFVTVIDLPKINKVAG--------KKFDRLSLLFF 281

  Fly   220 CILSGCDYLDSLPGIGLAKACKFILKTEQEDMRIALKKIPSYLNMRNLEVDDDYIENFMKAEATF 284
            .:|.|.||...:.|:|..|:.:.   .:.||...:::   .|...::..::|...|:..|:.
Yeast   282 SVLLGADYNRGVKGLGKNKSLQL---AQCEDPNFSME---FYDIFKDFNLEDLTSESLRKSR--- 337

  Fly   285 RHMFIYNPLERRMQRLCALEDYETDERYCSNAGTLLED--------------------------- 322
                 |...::|:...|  :|:.. |.:..|...||..
Yeast   338 -----YRLFQKRLYLYC--KDHSV-ELFGRNYPVLLNQGSFEGWPSTVAIMHYFHPIVQPYFDEE 394

  Fly   323 --SEQALHLA----------------LGNLNPFSMKRLDSWTPEKAWPTPKNVKRSKHKSIWQTN 369
              |::.:::|                |.:||...:...|.|..:           |.|:......
Yeast   395 VLSDKYINMAGNGHYRNLNFNELKYFLQSLNLPQISSFDKWFHD-----------SMHEMFLLRE 448

  Fly   370 FQSENTHTPKKENPCALFFKKVDFVGKTLNEEIEANQRLEQAK--QTEAELFNMYSFK------- 425
            |               |...:.|.:||       .|.|:.:.|  ..:...|.:..||
Yeast   449 F---------------LSIDESDNIGK-------GNMRITEEKIMNIDGGKFQIPCFKIRYTTFL 491

  Fly   426 ----------AKRRRSPSREDSVDQER----------------TPPPSP-----------VHKSR 453
                      .||..||||..|..:.:                .|...|           :.|.
Yeast   492 PNIPISSQSPLKRSNSPSRSKSPTRRQMDIMEHPNSLWLPKYLIPQSHPLVIQYYETQQLIQKE- 555

  Fly   454 HNPFAKERTGEEANQ-RSPVVCENASLLRLLSPKKASPLDGEAGVKKVDSLKRSIFAKEQVQIRS 517
                 ||:.|:::|: |.|........||    |..||:   ..:.||...::.|..    .:|.
Yeast   556 -----KEKKGKKSNKSRLPQKNNLDEFLR----KHTSPI---KSIGKVGESRKEILE----PVRK 604

  Fly   518 RFFATQDEQTRLQREHLRDTENDDMDEQKLSSHSGHKKLRLVCKDIPGKNPIRQRCSSQISDGET 582
            |.|...||.|.|:                               :||.  |.|.....:.||.:.
Yeast   605 RLFVDTDEDTSLE-------------------------------EIPA--PTRLTTVDEHSDNDD 636

  Fly   583 DT------DTTASSLLES----------QDKGVP--------SPLESQEDLNNSQPQIPTEG--N 621
            |:      .|.:.|:|:|          ||:.|.        ||::... ..|::...|..|  :
Yeast   637 DSLIFVDEITNSQSVLDSSPGKRIRDLTQDEQVDVWKDVIEISPIKKSR-TTNAEKNPPESGLKS 700

  Fly   622 TNSTTI--RIKSLDLLLENSPEPTQESDRNN-NDAIILLSDD------SCSSDQRASST 671
            .:|.||  |::...:|..|...|..|.:.:: .|.::..:.|      :|.||  :|||
Yeast   701 RSSITINARLQGTKMLPPNLTAPRLEREHSSVLDQLVTDAQDTVDRFVACDSD--SSST 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tos	NP_477145.1	PIN_EXO1	1..202	CDD:350207	44/236 (19%)
		H3TH_EXO1	214..291	CDD:188628	16/81 (20%)
YEN1	NP_010959.2	PIN_YEN1	2..275	CDD:350218	47/252 (19%)
		H3TH_YEN1	286..388	CDD:188626	20/118 (17%)