DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tos and EXO1

DIOPT Version :9

Sequence 1:	NP_477145.1	Gene:	tos / 35119	FlyBaseID:	FBgn0015553	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_014676.1	Gene:	EXO1 / 854198	SGDID:	S000005559	Length:	702	Species:	Saccharomyces cerevisiae

Alignment Length:	773	Identity:	196/773 - (25%)
Similarity:	318/773 - (41%)	Gaps:	163/773 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGITGLIPFVGKASSQLHLKDIRGSTVAVDTYCWLHKGVFGCAEKLARGEDTDVYIQYCLKYVNM 65
            |||.||:|.:....:.:.|:...|..:|:|.|.|||:....||.:||.|:.||.|:|:.:|..::
Yeast     1 MGIQGLLPQLKPIQNPVSLRRYEGEVLAIDGYAWLHRAACSCAYELAMGKPTDKYLQFFIKRFSL 65

  Fly    66 LLSYDIKPILVFDGQHLPAKALTEKRRRDSRKQSKERAAELLRLGRIEEARSHMRRCVDVTHDMA 130
            |.::.::|.|||||..:|.|..||.:|||.||::|..|..|...|..:.|..:.::|||:|.:||
Yeast    66 LKTFKVEPYLVFDGDAIPVKKSTESKRRDKRKENKAIAERLWACGEKKNAMDYFQKCVDITPEMA 130

  Fly   131 LRLIRECRSRNVDCIVAPYEADAQMAWLNRADVAQYIITEDSDLTLFGAKNIIFKLDLNGSGLLV 195
            ..:|..|:...:..||||:|||:||.:|.:.::.|.||:|||||.:||.:.:|.|  ||..|..:
Yeast   131 KCIICYCKLNGIRYIVAPFEADSQMVYLEQKNIVQGIISEDSDLLVFGCRRLITK--LNDYGECL 193

  Fly   196 E---------AEKLHLAMGCTEEKYHFDKFRRMCILSGCDYLDSLPGIGLAKACKFILKTEQEDM 251
            |         .:|..|.....||      ...|..||||||.:.:|.:||..|.|.:.:....:
Yeast   194 EICRDNFIKLPKKFPLGSLTNEE------IITMVCLSGCDYTNGIPKVGLITAMKLVRRFNTIE- 251

  Fly   252 RIALKKIPSYLNMRNLEVDDDYIENFMKAEATFRHMFIYNPLERRMQRLCALEDYETD-----ER 311
            ||.|    |......|.:.|.||..:..|...|:...::.|:.:::..|..:..|..|     :|
Yeast   252 RIIL----SIQREGKLMIPDTYINEYEAAVLAFQFQRVFCPIRKKIVSLNEIPLYLKDTESKRKR 312

  Fly   312 YCSNAGTLL-------------EDSEQALHL--ALGNLNPFSMKRLDSWTPEKAWPTPKNVKRSK 361
            ..:..|.::             :|.:..|||  |.|:|||:...:            |...:..|
Yeast   313 LYACIGFVIHRETQKKQIVHFDDDIDHHLHLKIAQGDLNPYDFHQ------------PLANREHK 365

  Fly   362 HKSIWQTNFQSENTHTPKKE---NPCALFFKKVDFVGKTLNEEIEANQRLEQAKQTEAELFNMYS 423
            .:...::|.:...|:|...|   .|...||:|:    ..|:...:....:...:|.|.:|    :
Yeast   366 LQLASKSNIEFGKTNTTNSEAKVKPIESFFQKM----TKLDHNPKVANNIHSLRQAEDKL----T 422

  Fly   424 FKAKRRRSPSREDSVDQERTPPPSPVHKSRHNPFAKERTGEEANQRSPVVCENASLLRLLSPKKA 488
            ...|||:..:.  :|.||.               .|:...:..|:.|..|.||..       :|.
Yeast   423 MAIKRRKLSNA--NVVQET---------------LKDTRSKFFNKPSMTVVENFK-------EKG 463

  Fly   489 SPLDGEAGVKKVDSLKRSIFAKE-QVQIRSRFFATQDEQTRLQREHLRDTENDDMDEQKLSSHSG 552
            ..:..........||:..:...: ..||.|.|..|..|......|.:.:..:|..:::|.|.
Yeast   464 DSIQDFKEDTNSQSLEEPVSESQLSTQIPSSFITTNLEDDDNLSEEVSEVVSDIEEDRKNSE--- 525

  Fly   553 HKKLRLVCKDIPGKNPIRQRCSSQISDGETDTDTTASSLLESQDKGVPS------PLESQEDLN- 610
                        ||. |.....:...||:.||....|...||:   ||:      |..||..::
Yeast   526 ------------GKT-IGNEIYNTDDDGDGDTSEDYSETAESR---VPTSSTTSFPGSSQRSISG 574

  Fly   611 -------------------NSQPQIPTEGNTNSTTIRIKSLDLLLENSPEPTQESDRNN------ 650
                               |.||..|...|..|     :.:..:.:|..:...::|..|
Yeast   575 CTKVLQKFRYSSSFSGVNANRQPLFPRHVNQKS-----RGMVYVNQNRDDDCDDNDGKNQITQRP 634

  Fly   651 ----------NDAIILLSDDSCSSDQRASSTSSSSQQRQNFLPTSKRRVGLSKPSTAK 698
                      :..|::   |..|.|:|.|..||.....:    :.||.:..:|.|.|:
Yeast   635 SLRKSLIGARSQRIVI---DMKSVDERKSFNSSPILHEE----SKKRDIETTKSSQAR 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tos	NP_477145.1	PIN_EXO1	1..204	CDD:189027	81/211 (38%)
tos	NP_477145.1	H3TH_EXO1	214..291	CDD:188628	22/76 (29%)
EXO1	NP_014676.1	PIN_EXO1	1..202	CDD:350207	79/202 (39%)
		H3TH_EXO1	215..287	CDD:188628	24/82 (29%)
		PTZ00108	<267..520	CDD:240271	57/296 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344967
Domainoid	1	1.000	91	1.000	Domainoid score	I1744
eggNOG	1	0.900	-	-		E1_COG0258
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I923
Isobase	1	0.950	-	0.927736	Normalized mean entropy	S3206
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003113
OrthoInspector	1	1.000	-	-		otm46949
orthoMCL	1	0.900	-	-		OOG6_101671
Panther	1	1.100	-	-	LDO	PTHR11081
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R423
SonicParanoid	1	1.000	-	-		X2084
TreeFam	1	0.960	-	-
	14	13.730