DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tos and RAD2

DIOPT Version :9

Sequence 1:	NP_477145.1	Gene:	tos / 35119	FlyBaseID:	FBgn0015553	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_011774.1	Gene:	RAD2 / 853174	SGDID:	S000003490	Length:	1031	Species:	Saccharomyces cerevisiae

Alignment Length:	832	Identity:	156/832 - (18%)
Similarity:	285/832 - (34%)	Gaps:	238/832 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGITGLIPFVGKASSQLHLKDIRGSTVAVDTYCWLHKGVFGCAEKLARGEDTDV----YIQYCLK 61
            ||:.......|..:..:.|:.:....:|||...|:::.:     |..|.::.:.    :|....:
Yeast     1 MGVHSFWDIAGPTARPVRLESLEDKRMAVDASIWIYQFL-----KAVRDQEGNAVKNSHITGFFR 60

  Fly    62 YVNMLLSYDIKPILVFDGQHLPAKALT----EKRRRDSRKQSKERAAELLRLG------------ 110
            .:..||.:.|:|:.||||.....|..|    ::||:..|:.:|..|.:||.|.
Yeast    61 RICKLLYFGIRPVFVFDGGVPVLKRETIRQRKERRQGKRESAKSTARKLLALQLQNGSNDNVKNS 125

  Fly   111 --------RI-------------------EEARSHMRRCVDVTHDMALRLIRECRSRNVDC-IVA 147
                    :|                   |:||.:..:    |.:..:..|......::|. .:.
Yeast   126 TPSSGSSVQIFKPQDEWDLPDIPGFKYDKEDARVNSNK----TFEKLMNSINGDGLEDIDLDTIN 186

  Fly   148 PYEADAQMAWLNRADVAQYIITED----SDLTLFGAKNII------------FKLDL-------- 188
            |  |.|:...|.:|  .||:|...    |.|.:..:|..:            |::|:
Yeast   187 P--ASAEFEELPKA--TQYLILSSLRLKSRLRMGYSKEQLETIFPNSMDFSRFQIDMVKRRNFFT 247

  Fly   189 ----------NGSGLLVEAEKLHLAMGCTEEKYHFDKFRRMCILSGCDYLDSLPGIGLAKACKFI 243
                      :|....:..|.::...|...::|...|.....||.    |.:..|....||
Yeast   248 QKLINTTGFQDGGASKLNEEVINRISGQKSKEYKLTKTNNGWILG----LGANDGSDAQKA---- 304

  Fly   244 LKTEQEDMRIALKKIPSYLNMRNLEVDDDYIENFMKAEATFRHMFIYNPLERRMQRLCALEDYET 308
            :..:.:|....:|::.|.....::...||..:|.:|   ..||. ..|......:|....||...
Yeast   305 IVIDDKDAGALVKQLDSNAEDGDVLRWDDLEDNSLK---IVRHE-SSNATTAPQKRSNRSEDEGC 365

  Fly   309 DERYC---------SNAGTLLEDSEQALHL-----ALGNL--NPFSMKRLDSWTPEKAWPTPKNV 357
            |...|         .|...:.:.|.:|..|     :|.|.  ..|..||.|..:|.|..||.:
Yeast   366 DSDECEWEEVELKPKNVKFVEDFSLKAARLPYMGQSLNNAGSKSFLDKRHDQASPSKTTPTMR-- 428

  Fly   358 KRSKHKSIWQTNFQSENTHTPKKENPCALFFKKVDFVGKTLNEEIEANQRLEQAKQTEAE----L 418
                   |.:.:.:.::..          :.|:::.:     |.:||.|..:..|:.||:    :
Yeast   429 -------ISRISVEDDDED----------YLKQIEEI-----EMMEAVQLSKMEKKPEADDKSKI 471

  Fly   419 FNMYSFKAKRRRSP--------SREDS-----VDQERTPPPSPVHKSRHNPFAKERTGEEANQRS 470
            ....:.|....|.|        ::.||     |....:...|.:.::.....::.|...:...:.
Yeast   472 AKPVTSKGTEARPPIVQYGLLGAQPDSKQPYHVTNLNSKSESVIKRTSKTVLSEFRPPSQQEDKG 536

  Fly   471 PVVCENASLLRLLSPK-----------------KASPLDGEAGVKK--VDSLKRSIFAKEQVQIR 516
            .::.|....|..:|.|                 ..|.:..||..:|  :..:.....:....|:.
Yeast   537 AILTEGEQNLNFISHKIPQFDFNNENSLLFQKNTESNVSQEATKEKSPIPEMPSWFSSTASQQLY 601

  Fly   517 SRFFAT---QDEQTRLQREHLRDTEND----------------DMDEQKLSSHSGHKKLRL---- 558
            :.:..|   :|:..|.::|...:|.|.                :.:.:|.||:..:|...|
Yeast   602 NPYNTTNFVEDKNVRNEQESGAETTNKGSSYELLTGLNATEILERESEKESSNDENKDDDLEVLS 666

  Fly   559 --VCKDIPGKNPIRQRCSSQISDGETDTDTTASSLLESQDKGVPSPL-------ESQED-----L 609
              :.:|:|.|        ||||....|.|   |..:||.:|....||       |.:||     :
Yeast   667 EELFEDVPTK--------SQISKEAEDND---SRKVESINKEHRKPLIFDYDFSEDEEDNIVENM 720

  Fly   610 NNSQPQIPTEGNTNSTTIRIKSL-------DLLLENSPEPTQESDRNNNDAI 654
            ...|.:..|..||..:|...:::       |.|.|...:..::||....|.|
Yeast   721 IKEQEEFDTFKNTTLSTSAERNVAENAFVEDELFEQQMKDKRDSDEVTMDMI 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tos	NP_477145.1	PIN_EXO1	1..204	CDD:189027	51/284 (18%)
tos	NP_477145.1	H3TH_EXO1	214..291	CDD:188628	16/76 (21%)
RAD2	NP_011774.1	rad2	1..1030	CDD:273166	156/832 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810