Protein Alignment tos and DIN7

DIOPT Version :10

• Sequence 1: NP_477145.1
• Gene: tos / 35119
• FlyBaseID: FBgn0015553
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_010549.3
• Gene: DIN7 / 851856
• SGDID: S000002671
• Length: 430
• Species: Saccharomyces cerevisiae
• Alignment Length: 467
• Identity: 119/467 - (25%)
• Similarity: 209/467 - (44%)
• Gaps: 84/467 - (17%)

  Fly     1 MGITGLIPFVGKASSQLHLKDIRGSTVAVDTYCWLHKGVFGCAEKLARGEDTDVYIQYCLKYVNM 65
            |||.||:|.:.:...|:.||.....|:|:|.|.|||:....||.:|...:.|:.|:|:.:|.:.:
Yeast     1 MGIPGLLPQLKRIQKQVSLKKYMYQTLAIDGYAWLHRASCACAFELVMNKPTNKYLQFFIKRLQL 65

  Fly    66 LLSYDIKPILVFDGQHLPAKALTEKRRRDSRKQSKERAAELLRLGRIEEARSHMRRCVDVTHDMA 130
            |....|||.:||||..|..|..||.|||..|.:::..|.:|...|....|..:.::.||:|.:||
Yeast    66 LKRLKIKPYIVFDGDSLFVKNHTETRRRKKRLENEMIAKKLWSAGNRYNAMEYFQKSVDITPEMA 130

  Fly   131 LRLIRECRSRNVDCIVAPYEADAQMAWLNRADVAQYIITEDSDLTLFGAKNIIFKLDLNGSGLLV 195
            ..:|..|:..::..||||:|||.||.:|.:..:.|.||:|||||.:||.|.:|.||:..|..|.:
Yeast   131 KCIIDYCKLHSIPYIVAPFEADPQMVYLEKMGLIQGIISEDSDLLVFGCKTLITKLNDQGKALEI 195

  Fly   196 EAEKL-----HLAMGCTEEKYHFDKFRRMCILSGCDYLDSLPGIGLAKACKFILK-TEQEDMRIA 254
            ..:..     :..:|...|:    :||.:..|:||||...:..:|:..|.|.:.: :|.:|:.|.
Yeast   196 SKDDFSALPENFPLGELSEQ----QFRNLVCLAGCDYTSGIWKVGVVTAMKIVKRYSEMKDILIQ 256

  Fly   255 LKKIPSYLNMRNLEVDDDYIENFMKAEATFRHMFIYNPLERRMQRLCALEDYETDE-----RYCS 314
            :::.......:..:...::      |...|::..::.||..::..|..:....|:.     :...
Yeast   257 IERTEKLCFSKAFKQQVEF------ANYAFQYQRVFCPLSNQITTLNNIPKAVTNSHAEIIKIMK 315

  Fly   315 NAGTLLE-------------DSEQALH--LALGNLNPFSMKRLDSWTPEKAWPTPKNVKRSKHKS 364
            ..|:::|             :.:..:|  :|.|.|:|..|             ..|.:.|.:
Yeast   316 CIGSVVERGSGVRKDVINTKNIDHKVHEMIAKGELHPVDM-------------ASKLINRER--- 364

  Fly   365 IWQTNFQSENTHTPKKENPCALFFKKVDFVGKTLNEEIEANQRLEQAKQTEAELFNMYSFKAKRR 429
                                .|..:|:..||....|....|:::||......::.:
Yeast   365 --------------------KLKARKLFKVGLLGGESNSFNKKVEQPLVDTQDVLS--------- 400

  Fly   430 RSPSREDSVDQE 441
               .||:|:|.:
Yeast   401 ---ERENSLDNK 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tos	NP_477145.1	PIN_EXO1	1..202	CDD:350207	76/205 (37%)
		H3TH_EXO1	214..291	CDD:188628	15/77 (19%)
DIN7	NP_010549.3	PIN_EXO1	1..202	CDD:350207	76/200 (38%)
		H3TH_StructSpec-5'-nucleases	215..287	CDD:473957	15/81 (19%)