DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tos and ercc5

DIOPT Version :9

Sequence 1:	NP_477145.1	Gene:	tos / 35119	FlyBaseID:	FBgn0015553	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_003197653.2	Gene:	ercc5 / 541502	ZFINID:	ZDB-GENE-050327-28	Length:	1010	Species:	Danio rerio

Alignment Length:	792	Identity:	143/792 - (18%)
Similarity:	278/792 - (35%)	Gaps:	236/792 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGITGLIPFVGKASSQLHLKDIRGSTVAVDTYCWLHKGVFGCAEK----LARGEDTDVYIQYCLK 61
            ||:.||...:......::.:.:.|..:|||...||::.|.|..::    :.......::.:.|
Zfish     1 MGVHGLWKLLESTGKPINPETLEGKILAVDISIWLNQAVKGVRDRDGNAVQNAHLLTLFHRLC-- 63

  Fly    62 YVNMLLSYDIKPILVFDGQHLPAK----ALTEKRRRDSRKQSKERAAELLRLGRIEEARSHMRRC 122
               .||.:.|:|:.|:||.....|    |:..:||.::.::|::.:.:||:.....:|   :|..
Zfish    64 ---KLLFFRIRPVFVYDGDAPLLKKQTLAVRRQRREETNRESRQTSEKLLQTFLKRQA---IRAA 122

  Fly   123 V-DVTHDMALRLIRECRSRNVDCIVAPY---EADAQMAWLNRADVAQYIITEDSDLTLFGAKNII 183
            : :.:.:.|..|....|..:.|..|.|.   |.|.|               |.|.
Zfish   123 LGENSQESAPSLSSVRRDEHDDIYVLPALPPEDDRQ---------------ESSS---------- 162

  Fly   184 FKLDLNGSGLLVEAEKLHLAMGCTEEKYHFDKFRRMCILSGCDYLDSLPGIGLAKACKFILKTEQ 248
                        |.||     ...|..:::.:|:...    ||..|::.           :.:||
Zfish   163 ------------EEEK-----DGDEALHNYSRFQEEL----CDNPDAVD-----------INSEQ 195

  Fly   249 EDMRIALKKIPSYLNMRNLEVDDDYIENFMKAEATFRHMFIYNPLER----------------RM 297
                         .::...|:..:.::. ||..:..|...::.|.||                |:
Zfish   196 -------------FSLMPPEIKHEILKE-MKEFSKRRRTLLHKPPERSGEFSQYQLAGLLQRNRL 246

  Fly   298 -QRLCALEDY--------ETDERYCSNAGTLLEDSEQALHLALGNLNPFSMKRLDS--------- 344
             |||..:|..        .||::.......:.|||...:.:..|      .|::.:
Zfish   247 NQRLECVEQEMNQRSSGGHTDQQNTEIRRLVSEDSSHYILIKGG------QKKVSAVATPAAPAL 305

  Fly   345 WTPEKAWPTPKNVKRSKHKSIW------QTNFQSENTHTPKKE------NPCALFF--------- 388
            |: ...| .||...:.|.:.:|      :.|..|.::.:|:.:      :|..|..
Zfish   306 WS-SSPW-EPKGRNKGKPEPLWRPVSEEEENKPSSSSSSPEDQSAGAPASPRTLLAIQSAMMESE 368

  Fly   389 ----------KKVDFV---GKTLNEEIEANQRLE----QAKQTEAELFNMYSFKAKRR-RSPSRE 435
                      .|.:.:   .||..::|: |.|..    .:..:|.|..::.:.:|:.. .:.|.|
Zfish   369 DEDQQIQDSRSKTNIIPSSSKTEEQQIQ-NSRTRTHVITSSSSEDEDQHIQNSRARTHIITSSSE 432

  Fly   436 DSVDQERTPPPSPVHKSRHNPFAKERTGEEANQRSPVVCENASLLRLLSPKKASPLDGEAGVKKV 500
            |..:..||..|:|           ..|..:...|:|:...:|:...|   ::...|..:|...:.
Zfish   433 DETEIRRTSDPAP-----------GTTDLKLESRTPLSLASAASGSL---EQTHTLQQDAESSED 483

  Fly   501 DSLKRSIF--AKEQVQIRSRFFATQDEQTRL-QREHLRDTENDDMDEQKLSSHSGHKKLRLVCKD 562
            :|....|.  .:.:.|.::|....::|::.: |....||:.:....|::              :|
Zfish   484 ESRSSVILDCVRSETQRKTREEEEKEEESTVNQILQFRDSRDPSEKEER--------------ED 534

  Fly   563 IPGKNPIRQRCSSQISDGETDTDTTASSLLESQDKGVPSPLESQEDLNNSQPQIPT--------- 618
            .|.:|..::.        |.:..:...|.:|..|...| |...:..:|..|....|
Zfish   535 QPEENREKRE--------EEEESSADESFVEVSDAEEP-PETDESHINTHQTDYNTEEKEEEVEE 590

  Fly   619 -EGNTNSTTIRIKSLDLLLENSP----------EPTQESDRNNNDAIILLSDDSCSSDQRASSTS 672
             |.::..:|.:|:.:|..:..:|          |..|..||...|....|.:.. ...||:|||.
Zfish   591 EEESSAQSTDQIEDVDESVNEAPAVSEWEHIDTEELQLLDRELQDEQQTLREQH-QQQQRSSSTV 654

  Fly   673 SSS--QQRQNFL 682
            :..  |:.|..|
Zfish   655 TGQMCQESQELL 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tos	NP_477145.1	PIN_EXO1	1..204	CDD:189027	43/214 (20%)
tos	NP_477145.1	H3TH_EXO1	214..291	CDD:188628	10/76 (13%)
ercc5	XP_003197653.2	rad2	1..909	CDD:273166	143/792 (18%)
		PIN_XPG	1..>120	CDD:189038	28/126 (22%)
		PIN_SF	<626..872	CDD:301351	13/42 (31%)
		H3TH_XPG	740..832	CDD:188624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810