DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tos and mus201

DIOPT Version :9

Sequence 1:	NP_477145.1	Gene:	tos / 35119	FlyBaseID:	FBgn0015553	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_001027230.1	Gene:	mus201 / 3772069	FlyBaseID:	FBgn0002887	Length:	1236	Species:	Drosophila melanogaster

Alignment Length:	862	Identity:	169/862 - (19%)
Similarity:	308/862 - (35%)	Gaps:	233/862 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGITGLIPFVGKASSQLHLKDIRGSTVAVDTYCWLHKGVFGCAEK----LARGEDTDVYIQYCLK 61
            ||:|||...:......:.::.:.|..:|||...|||:.|.|..:.    |:......::.:.|
  Fly     1 MGVTGLWKLIEPCGKPVPVETLEGKILAVDISIWLHQVVKGFQDNKGSALSNAHLLGLFHRLC-- 63

  Fly    62 YVNMLLSYDIKPILVFDGQHLPAKALTEKRRRDSR-KQSKE--RAAELLRLGRIEEARSHMRRCV 123
               .||.|.::|:.:|||.....|..|..||:..| |.|.|  |...||.....:|
  Fly    64 ---KLLYYRVRPVFIFDGCVPQLKRDTIARRQQQRNKLSNEADRIQALLLQSLAKE--------- 116

  Fly   124 DVTHDMALRLIRECRSRNVDCIV-APYEADAQMAWLNRADVAQYIITEDSDLTLFGAKNIIFKL- 186
                    :::::...:|.:.:: :|         :.|...|:.  .::.||         |||
  Fly   117 --------KVVQQALGKNAELLLKSP---------VKRPPPAKK--NDEDDL---------FKLP 153

  Fly   187 DLNGSGLLVEAEKLHLAMGCTEEKYHFDK-FRRMCILSGCDYLD-------SLPGIGLAKACKFI 243
            :|..:.:....::.......:.....||: ..|....|....:|       :||.....:....|
  Fly   154 ELPAASVQDNQDESEQDTSASASDSSFDESTARHSYNSSLQAIDVKSQHFRNLPADVRHEILTDI 218

  Fly   244 LKTEQEDMRIALKKIPSYLNMRNLEVDDDYIENFMKAEATFRHMFIYNPLERRMQRL-------C 301
            .:|.::.....|.::|:.        .||:....||  ...:...:...||:..|.:       .
  Fly   219 KETRKQSSWGRLHELPAR--------SDDFCSFQMK--RLLKRRAVQESLEQAEQEMGGHTLTYA 273

  Fly   302 ALEDYETDE--------RYCSNAGTLLEDSEQALHLALGNLNPFSMKRLDSWTPEKAWPTPKNVK 358
            .|.|:..:|        ..|:..   :...|....|.:.:|...:|:           .|.:.||
  Fly   274 ELCDFFNEEGILTPTAIEQCTRQ---ISSDEHTRFLLVRDLKKKAME-----------STKQEVK 324

  Fly   359 RSKHKSIWQTNFQSENTHTPKKENPCALFFKKVDFVGKTLNEEI--EANQRLEQAKQTEAELFNM 421
            ....:.:.......:.:.:.|||     ..|.|| :|...:|::  ..:..:|:.|..:.:.:..
  Fly   325 MEMIEEVPAEEEDEKPSTSTKKE-----AVKSVD-LGTEFDEDLAKALSMSMEETKVYDEKDYEY 383

  Fly   422 YSFKAKR-RRSPSREDSVDQERTPPPSPVHKSRHNPFAKERTGE--EANQRSPVVCENASLLRLL 483
            .|.:..| .|:.:::   .:.....|:..:...:.....|..|.  ||.|.:    :..||.:||
  Fly   384 DSDQELRLNRAQTKQ---LRHAAKGPARAYMIEYGGMNDEEVGNIMEATQFN----DTQSLEKLL 441

  Fly   484 SPKKASPLD-GEAGVKKVDSLKRSIFAKEQVQIRSRFFATQDEQTRLQREHLR--DTEND-DMDE 544
            ..... |.| .:..:::...:.::|  :|..|:..   |.::.:..|..:.:.  ||:.| |::|
  Fly   442 EITTV-PTDMADNSIEEAKLISQAI--EESKQLSQ---AIEESKKNLNEDKVEIVDTDTDSDLEE 500

  Fly   545 ----QKLSSHSGHKKLRLVCKDIPGK----------------NPIRQRCSSQISDGETDTDTTAS 589
                |:|.  .|.|.|. :|.||.|:                |.|.:..|.:..|...:...:..
  Fly   501 VMEVQELD--KGKKNLE-ICVDITGQADSNDLFADIFEDGEANKIEKTISVEEDDDFIEVKDSEE 562

  Fly   590 SLLESQDKGVP----SPLESQE---------DLNNSQPQIPTEGN-----------TNSTTIRIK 630
            ..|:::|:..|    |..||.|         ::.:||..:|.|.|           ....|..:|
  Fly   563 LKLDTEDENKPITNKSIKESNEVKPFIDEIIEVKDSQEAVPAEPNLKPDLESILNDLKKQTAAVK 627

  Fly   631 SLDLLL--ENSPEPTQESDR----------------------NNNDAIILLSDDS---------- 661
            .:.|.:  |..|:|..|...                      :|:..|||.|||.
  Fly   628 DIQLNVNEEEKPKPKVEISSILDELKVKMADVKNITLDNVKLSNSVPIILSSDDESTLKSSKIVP 692

  Fly   662 -------CSSDQRASS------TSSSSQQRQNFLPTS---KRRVGLSKPST-AKKGTPKS----- 704
                   |.||...::      |.|.::..::|..||   ||....|:.|. ...||||:
  Fly   693 KQELIELCDSDDNKNNRLSPNKTPSKNKSIKDFFETSYVVKRTPDKSQASNETSPGTPKTPKPFF 757

  Fly   705 --RT--NGKLGAVSQNQ 717
              ||  :|:..|...|:
  Fly   758 RKRTPKSGRKRASDANE 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tos	NP_477145.1	PIN_EXO1	1..204	CDD:189027	45/211 (21%)
tos	NP_477145.1	H3TH_EXO1	214..291	CDD:188628	14/84 (17%)
mus201	NP_001027230.1	rad2	1..1122	CDD:273166	169/862 (20%)
		PIN_XPG	1..>121	CDD:189038	35/141 (25%)
		PIN_XPG	<814..1084	CDD:189038
		H3TH_XPG	940..1045	CDD:188624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440832
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11081
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940