Protein Alignment tos and GEN1

DIOPT Version :10

• Sequence 1: NP_477145.1
• Gene: tos / 35119
• FlyBaseID: FBgn0015553
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_872431.5
• Gene: GEN1 / 348654
• HGNCID: 26881
• Length: 908
• Species: Homo sapiens
• Alignment Length: 910
• Identity: 167/910 - (18%)
• Similarity: 296/910 - (32%)
• Gaps: 269/910 - (29%)

  Fly     1 MGITGLIPFVGKASSQLHLKDIRGSTVAVDTYCWLHKGVFGCAEKLAR---GEDTDVYIQYCLKY 62
            ||:..|...:......:.|:::.|.|:|||...|:      |..:..:   |.....:::.....
Human     1 MGVNDLWQILEPVKQHIPLRNLGGKTIAVDLSLWV------CEAQTVKKMMGSVMKPHLRNLFFR 59

  Fly    63 VNMLLSYDIKPILVFDGQHLPAKALTEKRRRDSRKQSKERAAELLRLGRIEEARSHMRRCVDVTH 127
            ::.|...|:|.:.|.:|:....||....:|..||..|..::...      :..|||.:
Human    60 ISYLTQMDVKLVFVMEGEPPKLKADVISKRNQSRYGSSGKSWSQ------KTGRSHFK------- 111

  Fly   128 DMALRLIRECRSRNVDCIVAPY-----EADAQMAWLNRADVAQYIITEDSDLTLFGAKNIIFKLD 187
                .::||| ...::|:..|:     ||:|..|:||........:|.|.|..|:||:.:.....
Human   112 ----SVLREC-LHMLECLGIPWVQAAGEAEAMCAYLNAGGHVDGCLTNDGDTFLYGAQTVYRNFT 171

  Fly   188 LNGSGLLVEAEKLHLAMGCTEEKYHFDK--FRRMCILSGCDYL-DSLPGIGLAKACKF--ILKTE 247
            :|.....|:.    ..|...:.|...|:  ...:.||.||||| ..:||:|..:|.|.  |||.:
Human   172 MNTKDPHVDC----YTMSSIKSKLGLDRDALVGLAILLGCDYLPKGVPGVGKEQALKLIQILKGQ 232

  Fly   248 QEDMRI------ALKKIPSYLNMRNLEVDDDYIENFMKAEATF-RHMFIYNPLERRMQRLCALED 305
            ....|.      :....|..|..:.|            |..:. .|.......||...|||..:.
Human   233 SLLQRFNRWNETSCNSSPQLLVTKKL------------AHCSVCSHPGSPKDHERNGCRLCKSDK 285

  Fly   306 Y--ETDERYCSNAGTLLEDSEQALHLALGNLN---------PF---------------------- 337
            |  ..|..||........:.::.|.....|:.         ||
Human   286 YCEPHDYEYCCPCEWHRTEHDRQLSEVENNIKKKACCCEGFPFHEVIQEFLLNKDKLVKVIRYQR 350

  Fly   338 -SMKRLDSWTPEK-AWPT----PKNVKRSKHKSIWQTNFQSENTHTPKKENPCALFFKKV----- 391
             .:.....:|.|| .||.    .|.:....|..:.:....|.|::   :..|..:...::
Human   351 PDLLLFQRFTLEKMEWPNHYACEKLLVLLTHYDMIERKLGSRNSN---QLQPIRIVKTRIRNGVH 412

  Fly   392 --------------------DFVGKTLNEE------------IEANQRLEQAKQTEAELFNMYSF 424
                                :|...|:.||            :...|:||...:.:..:
Human   413 CFEIEWEKPEHYAMEDKQHGEFALLTIEEESLFEAAYPEIVAVYQKQKLEIKGKKQKRI------ 471

  Fly   425 KAKRRRSPSREDSVDQERTPPPSPVHKSRHNPFAKERTGEEANQRSPVVCENASLLRLLSPKKAS 489
            |.|....|..::.:..:......|..:..|...:|..:|...:...|....:|||..||.||...
Human   472 KPKENNLPEPDEVMSFQSHMTLKPTCEIFHKQNSKLNSGISPDPTLPQESISASLNSLLLPKNTP 536

  Fly   490 PLDGE---------AGVKKVDSLKRSIFAKE---------------------------------- 511
            .|:.:         ..::::.::.:|:.::.
Human   537 CLNAQEQFMSSLRPLAIQQIKAVSKSLISESSQPNTSSHNISVIADLHLSTIDWEGTSFSNSPAI 601

  Fly   512 ---------QVQIRSRFFATQD------EQTRLQRE----HLRDTENDDMDEQKLSSH--SGHKK 555
                     :.::.|...|..|      ||...:.|    :::...::|.|......|  ||...
Human   602 QRNTFSHDLKSEVESELSAIPDGFENIPEQLSCESERYTANIKKVLDEDSDGISPEEHLLSGITD 666

  Fly   556 LRLVCKDIPGKNPIRQRCSSQISDGETDTDTTASSLLESQDK------------------GVPSP 602
            |.|  :|:|.|..|..:.|....:.:.|.:....|:|..::.                  |:|..
Human   667 LCL--QDLPLKERIFTKLSYPQDNLQPDVNLKTLSILSVKESCIANSGSDCTSHLSKDLPGIPLQ 729

  Fly   603 LES------------QED--LNNSQPQIPTEGNTNSTTIRIKSLDLLLENSPEPTQESDRNNNDA 653
            .||            |||  :|.|.|.  :..||...|..::..:..|::|.:...::.|.
Human   730 NESRDSKILKGDQLLQEDYKVNTSVPY--SVSNTVVKTCNVRPPNTALDHSRKVDMQTTRK---- 788

  Fly   654 IILLSDDSC----SSDQRASST-------------SSSSQQRQNFLPTSKRRVGLSKPSTAKKGT 701
             ||:....|    |||::::..             ||......:|..:...:  ||.|....|.|
Human   789 -ILMKKSVCLDRHSSDEQSAPVFGKAKYTTQRMKHSSQKHNSSHFKESGHNK--LSSPKIHIKET 850

  Fly   702  701
            Human   851  850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tos	NP_477145.1	PIN_EXO1	1..202	CDD:350207	45/208 (22%)
		H3TH_EXO1	214..291	CDD:188628	22/88 (25%)
GEN1	NP_872431.5	PIN_GEN1	2..206	CDD:350217	49/231 (21%)
		XPG-N domain. /evidence=ECO:0000269|PubMed:26682650	2..96		21/99 (21%)
		XPG-I domain. /evidence=ECO:0000269|PubMed:26682650	122..208		22/89 (25%)
		H3TH_GEN1	195..338	CDD:188625	34/154 (22%)
		5'-3' exonuclease domain. /evidence=ECO:0000269|PubMed:26682650	208..384		37/187 (20%)
		Chromodomain. /evidence=ECO:0000269|PubMed:26682650	390..464		10/76 (13%)
		Chromo_2	398..458	CDD:465841	5/59 (8%)