DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tos and Gen1

DIOPT Version :9

Sequence 1:	NP_477145.1	Gene:	tos / 35119	FlyBaseID:	FBgn0015553	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_006239958.1	Gene:	Gen1 / 298884	RGDID:	1559792	Length:	910	Species:	Rattus norvegicus

Alignment Length:	755	Identity:	155/755 - (20%)
Similarity:	282/755 - (37%)	Gaps:	187/755 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGITGLIPFVGKASSQLHLKDIRGSTVAVDTYCWLHKGVFGCAEKLAR---GEDTDVYIQYCLKY 62
            ||:..|...:......:||:|:.|.|:|||...|:      |..:..:   |.....:::.....
  Rat     1 MGVNDLWQILEPVKQHIHLQDLCGKTIAVDLSLWV------CEAQTVKKMIGTVMKPHLRNLFFR 59

  Fly    63 VNMLLSYDIKPILVFDGQHLPAKALTEKRRRDSR--KQSKERAAELLRLGRIEEARSHMRRCVDV 125
            ::.|...::|.:.|.:|:....||....:|..:|  ...|.|:.        :..|||.:
  Rat    60 ISYLTQMNVKLVFVMEGEPPKLKADVMNKRTQTRYGPSGKSRSQ--------KTGRSHFK----- 111

  Fly   126 THDMALRLIRECRSRNVDCIVAPY-----EADAQMAWLNRADVAQYIITEDSDLTLFGAKNIIFK 185
                  .::|||... ::|:..|:     ||:|..|:||.:......:|.|.|..|:||:.:...
  Rat   112 ------SVLRECLEM-LECLGMPWVQAAGEAEAMCAYLNASGHVDGCLTNDGDAFLYGAQTVYRN 169

  Fly   186 LDLNGSGLLVEAEKLHLAMGCTEEKYHFDK--FRRMCILSGCDYL-DSLPGIGLAKACKF--ILK 245
            ..:|.....|:.    ..:...:.|...|:  ...:.:|.||||| ..:||:|..:|.|.  |||
  Rat   170 FTMNTKDPHVDC----YTVSSIKSKLGLDRDALVGLAVLLGCDYLPKGVPGVGKEQALKLLQILK 230

  Fly   246 TEQEDMRIALKKIPSYLNMRNLEVDDDYIENFMKAEATFRHMFIYNPLERRMQRLCALEDYETDE 310
            .:.     .|::...:.......|.....:..:.. :...|.......||....||      ..:
  Rat   231 GQS-----LLQRFNQWTEEPGYSVPQSAAKKVVHC-SVCSHPGSPKDHERNGCTLC------KSD 283

  Fly   311 RYCSNAGTLLEDSEQALHLALGNLNPFSMKRLDSWTPEKAWPTPKNVKRSKHKSIWQTNFQSENT 375
            |||                     .|...:.|          .|....::.|..  |.| :.||
  Rat   284 RYC---------------------EPHDYEYL----------CPCEWHQTDHNR--QLN-EIEN- 313

  Fly   376 HTPKKENPCALF-FKKV--DFVGKTLNEEIEANQRLEQAKQTEAELFNMYSFKAKRRRSPSR--- 434
            :..||...|..| |.:|  :|:.       ..|:.|:..:....:|.....|..::...||.
  Rat   314 NIKKKACSCEGFPFHEVIQEFLS-------NKNKLLKPIRYQRPDLLLFQRFTVQKMEWPSHYAC 371

  Fly   435 EDSVDQERTPPPSPVHKSRHNPFAKERTGEEANQRSPV----------VC---------ENASL- 479
            |..:          |..:|::...::...:.:||..|:          ||         |:.|:
  Rat   372 EKLL----------VLLTRYDMIERKLGRKTSNQLQPIRIVKPRIRNGVCCLEIEWEKPEHYSVE 426

  Fly   480 ------LRLLSPKKASPLDGEAGVKKVDSLKRSIFAKEQVQIRSRFFATQDEQTRLQREHLRDTE 538
                  |.||:.::||..  ||...:|    .:|:.|:|.:.:.:...::|.:.:.:..||  .|
  Rat   427 DTQPGGLDLLTIEEASLF--EAAYPEV----VAIYQKQQSETKGKKQKSKDIKIKPKGSHL--PE 483

  Fly   539 NDDMDEQKLSSHSGHKKLRLVCKDIPGKNPIRQRCSSQIS-DGETDTDTTASSL----------- 591
            :||:    :||.| ...|..:.|..|.:||   :...:|| |.....::|:.||
  Rat   484 SDDV----ISSQS-LITLEPISKAFPKQNP---KFDLEISPDPILAQESTSPSLSSFVSPENALG 540

  Fly   592 LESQDKGVPSP----LESQEDLNN------SQPQIPTEGNTNSTTIRIKSLD---LLLENSPEP- 642
            |..|::.:|||    ::..:|::|      |||...:...:..|.:.:.::|   ....|||..
  Rat   541 LNLQEQLMPSPRTLAVKQTKDVSNFLVSECSQPSSSSHNISVITDLHLSTIDWAGTSFSNSPAVQ 605

  Fly   643 ----TQESDRNNNDAIILLSDDSCSSDQRASSTSSSSQQR 678
                :|:.......:.||.:.:..|.:....:.|:....|
  Rat   606 RNTFSQDLQSEPESSAILPAFEQLSYESEQCTLSNKVSNR 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tos	NP_477145.1	PIN_EXO1	1..204	CDD:189027	46/212 (22%)
tos	NP_477145.1	H3TH_EXO1	214..291	CDD:188628	18/81 (22%)
Gen1	XP_006239958.1	PIN_GEN1	1..193	CDD:189039	47/221 (21%)
Gen1	XP_006239958.1	H3TH_StructSpec-5'-nucleases	195..337	CDD:304556	39/195 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810