DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tos and Exo1

DIOPT Version :9

Sequence 1:	NP_477145.1	Gene:	tos / 35119	FlyBaseID:	FBgn0015553	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_036142.2	Gene:	Exo1 / 26909	MGIID:	1349427	Length:	837	Species:	Mus musculus

Alignment Length:	785	Identity:	259/785 - (32%)
Similarity:	385/785 - (49%)	Gaps:	113/785 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGITGLIPFVGKASSQLHLKDIRGSTVAVDTYCWLHKGVFGCAEKLARGEDTDVYIQYCLKYVNM 65
            |||.||:.|:.:||..:::|..:|..||||||||||||...||||||:||.||.|:.:|:|:|||
Mouse     1 MGIQGLLQFIQEASEPVNVKKYKGQAVAVDTYCWLHKGAIACAEKLAKGEPTDRYVGFCMKFVNM 65

  Fly    66 LLSYDIKPILVFDGQHLPAKALTEKRRRDSRKQSKERAAELLRLGRIEEARSHMRRCVDVTHDMA 130
            ||||.:||||:|||..||:|...|:.||:.|:.:..:..:|||.|::.|||....|.:::||.||
Mouse    66 LLSYGVKPILIFDGCTLPSKKEVERSRRERRQSNLLKGKQLLREGKVSEARDCFARSINITHAMA 130

  Fly   131 LRLIRECRSRNVDCIVAPYEADAQMAWLNRADVAQYIITEDSDLTLFGAKNIIFKLDLNGSGLLV 195
            .::|:..|:..|||:|||||||||:|:||:|.:.|.:|||||||..||.|.:|.|:|..|:||.|
Mouse   131 HKVIKAARALGVDCLVAPYEADAQLAYLNKAGIVQAVITEDSDLLAFGCKKVILKMDQFGNGLEV 195

  Fly   196 EAEKLHLAMGCTE--EKYHFDKFRRMCILSGCDYLDSLPGIGLAKACKFILKTEQEDMRIALKKI 258
            :..:|.:   |.:  :.:..:|||.||||||||||.||.|||||||||.:......|:...:|||
Mouse   196 DQARLGM---CKQLGDVFTEEKFRYMCILSGCDYLASLRGIGLAKACKVLRLANNPDIVKVIKKI 257

  Fly   259 PSYLNMRNLEVDDDYIENFMKAEATFRHMFIYNPLERRMQRLCALEDYETDERYCSNAGTLLEDS 323
            ..||.| |:.|.:|||..|::|..||.:..:::|::|::..|.|..| :.:....:.||..:.||
Mouse   258 GHYLRM-NITVPEDYITGFIRANNTFLYQLVFDPIQRKLVPLNAYGD-DVNPETLTYAGQYVGDS 320

  Fly   324 EQALHLALGNLNPFSMKRLDSWTPE--------KAWPTPKNVKRSKHKSIWQTNF-----QSENT 375
             .||.:||||.:..:.:::|.::|:        .:|......|.....|||..|:     .:..:
Mouse   321 -VALQIALGNRDVNTFEQIDDYSPDTMPAHSRSHSWNEKAGQKPPGTNSIWHKNYCPRLEVNSVS 384

  Fly   376 HTPK-KENPCALFFKKV-DFVGKTLNEEIEANQRLEQAKQTEAELFNMYSFKAKRRRSPSREDSV 438
            |.|: ||.|..|..|:| ...|..|..:....:|.......|.:|.:.||..:|:    .:|:..
Mouse   385 HAPQLKEKPSTLGLKQVISTKGLNLPRKSCVLKRPRNEALAEDDLLSQYSSVSKK----IKENGC 445

  Fly   439 DQERTPPPSPVHKSRHNPFAKERTGEEANQRSPVVCENASLLRLLSPKKASPLDGEAGVKKVDSL 503
            ....:|..|.:.||..:.....:|  :|:..|.:..:.|:.|:..:.        |:|...|..
Mouse   446 GDGTSPNSSKMSKSCPDSGTAHKT--DAHTPSKMRNKFATFLQRRNE--------ESGAVVVPG- 499

  Fly   504 KRSIFAKEQVQIRSRFF-ATQDEQTRLQREHLRDTENDDMDEQK-LSSHSGHKKLRLVCKDIPGK 566
                       .||||| ::||....:.::......|:.:...| .:|..|    .|.|.|..|.
Mouse   500 -----------TRSRFFCSSQDFDNFIPKKESGQPLNETVATGKATTSLLG----ALDCPDTEGH 549

  Fly   567 NPI----RQRCSSQI-SDGETDTDTTASSLLESQDKGVPSPLESQEDLNNSQPQIPTEGNTNST- 625
            .|:    ....|||| .:.....:..|.|...|:..|..||              |:.|...|.
Mouse   550 KPVDANGTHNLSSQIPGNAAVSPEDEAQSSETSKLLGAMSP--------------PSLGTLRSCF 600

  Fly   626 ----TIRIKSLDLLLENSPEP----TQESDRNNNDAIILLSD------DSCSSDQR--------- 667
                |:|..|      .:|.|    |.:..|..:|....|.:      |.|.|...
Mouse   601 SWSGTLREFS------RTPSPSASTTLQQFRRKSDPPACLPEASAVVTDRCDSKSEMLGETSQPL 659

  Fly   668 ----ASSTSSSSQQRQNFLPTSKRRVGLSKPSTAKKGTPKSRTNGK-LGAVSQNQTKLSMFGFQT 727
                .||.|..|......|.||    .||:||:...|:.:|..|.| |....:..:|..:..|..
Mouse   660 HELGCSSRSQESMDSSCGLNTS----SLSQPSSRDSGSEESDCNNKSLDNQGEQNSKQHLPHFSK 720

  Fly   728 KPVLK 732
            |..|:
Mouse   721 KDGLR 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tos	NP_477145.1	PIN_EXO1	1..204	CDD:189027	105/202 (52%)
tos	NP_477145.1	H3TH_EXO1	214..291	CDD:188628	40/76 (53%)
Exo1	NP_036142.2	PIN_EXO1	1..201	CDD:350207	104/199 (52%)
		N-domain	1..99		56/97 (58%)
		Interaction with MSH3. /evidence=ECO:0000250	129..386		103/262 (39%)
		I-domain	138..229		50/93 (54%)
		H3TH_EXO1	213..289	CDD:188628	40/76 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	345..367		2/21 (10%)
		Interaction with MLH1. /evidence=ECO:0000250	387..488		25/106 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	440..477		8/38 (21%)
		AF-4	555..>765	CDD:368289	45/195 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	555..589		8/33 (24%)
		Interaction with MSH2. /evidence=ECO:0000250	591..837		35/145 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	608..740		30/128 (23%)
		Interaction with MLH1. /evidence=ECO:0000250	778..837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844244
Domainoid	1	1.000	126	1.000	Domainoid score	I5424
eggNOG	1	0.900	-	-		E1_COG0258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I2435
Isobase	1	0.950	-	0.927736	Normalized mean entropy	S3206
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003113
OrthoInspector	1	1.000	-	-		oto95117
orthoMCL	1	0.900	-	-		OOG6_101671
Panther	1	1.100	-	-	LDO	PTHR11081
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R423
SonicParanoid	1	1.000	-	-		X2084
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.730