DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tos and exo1

DIOPT Version :9

Sequence 1:	NP_477145.1	Gene:	tos / 35119	FlyBaseID:	FBgn0015553	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_596050.1	Gene:	exo1 / 2540348	PomBaseID:	SPBC29A10.05	Length:	571	Species:	Schizosaccharomyces pombe

Alignment Length:	530	Identity:	156/530 - (29%)
Similarity:	251/530 - (47%)	Gaps:	64/530 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGITGLIPFVGKASSQLHLKDIRGSTVAVDTYCWLHKGVFGCAEKLARGEDTDVYIQYCLKYVNM 65
            |||.||:..:.......|:::..|.|:.||.|.||||.||.||.:||..::||.|::|.:....|
pombe     1 MGIKGLLGLLKPMQKSSHVEEFSGKTLGVDGYVWLHKAVFTCAHELAFNKETDKYLKYAIHQALM 65

  Fly    66 LLSYDIKPILVFDGQHLPAKALTEKRRRDSRKQSKERAAELLRLGRIEEARSHMRRCVDVTHDMA 130
            |..|.:||::||||..||.||.||::|::.|:::.|...:|...|:..:|.....||||||.:||
pombe    66 LQYYGVKPLIVFDGGPLPCKASTEQKRKERRQEAFELGKKLWDEGKKSQAIMQFSRCVDVTPEMA 130

  Fly   131 LRLIRECRSRNVDCIVAPYEADAQMAWLNRADVAQYIITEDSDLTLFGAKNIIFKLDLNGSGL-- 193
            .:||...|...::.||||||||||:.:|.:.::...|||||||:.:|||:.::||:|..|:.:
pombe   131 WKLIIALREHGIESIVAPYEADAQLVYLEKENIIDGIITEDSDMLVFGAQTVLFKMDGFGNCITI 195

  Fly   194 ----LVEAEKLHLAMGCTEEKYHFDKFRRMCILSGCDYLDSLPGIGLAKACKFILKTEQEDMRIA 254
                :..|:.|:|       :...:|.|.|.|.|||||.|.:.|:||..|.:::.|..:....|.
pombe   196 RRNDIANAQDLNL-------RLPIEKLRHMAIFSGCDYTDGVAGMGLKTALRYLQKYPEPRAAIR 253

  Fly   255 LKKIPSYLNMRNLEVDDDYIENFMKAEATFRHMFIYNPLERRMQRLCALEDYETDERYCSNAGTL 319
            ..::.     ::|:|...:.:.|..|:..|||..:|.|.::.:..|...| .|......:..|:.
pombe   254 AMRLD-----KSLKVPVSFEKEFALADLAFRHQRVYCPKDKTLVHLSPPE-RELSVHEDAFIGSF 312

  Fly   320 LEDSEQALHLALGNLNPFSMKRLDSWTPEKAWPTPKNVKRSKHKSIWQT---NFQSENTHTPKKE 381
            . |::.|:.:|.|..||.:....|.........|...:..||.|.|.:|   ||..::  .|..:
pombe   313 F-DNQLAIDIAEGRSNPITKCAFDIKDSSMQSFTKTTITISKRKGISKTDISNFFMKS--IPPSK 374

  Fly   382 NPCALFFKKVDFVGKTLNEEIEANQRLEQAKQTEAELFNMYSFKAKRRRSP---SREDSVDQERT 443
            .|.    |....:..| |.::   ||...|....:|..::.|...|...:|   |.:....:..:
pombe   375 RPT----KSTSLIDVT-NVKV---QRTHLANDISSEKQSIKSANEKAYVTPKSNSLKPGFGKSLS 431

  Fly   444 PPPSPVHKSRHNPFAKERTG------------EEANQRSPVVCENA----------------SLL 480
            ...:...|:.:.||...|||            :|.:::.|....|.                |..
pombe   432 DISNSATKNENVPFLPPRTGVSKYFKLQKNTEKEIDEQVPSQSNNTTPTSAKSDSASPQNWFSSF 496

  Fly   481 RLLSPKKASP 490
            ...:|..|||
pombe   497 SYQTPNSASP 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tos	NP_477145.1	PIN_EXO1	1..204	CDD:189027	85/208 (41%)
tos	NP_477145.1	H3TH_EXO1	214..291	CDD:188628	23/76 (30%)
exo1	NP_596050.1	PIN_EXO1	1..206	CDD:189027	83/204 (41%)
		Exo	14..314	CDD:223336	109/313 (35%)
		H3TH_EXO1	213..285	CDD:188628	23/76 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	94	1.000	Domainoid score	I1963
eggNOG	1	0.900	-	-		E1_COG0258
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	215	1.000	Inparanoid score	I931
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003113
OrthoInspector	1	1.000	-	-		oto102036
orthoMCL	1	0.900	-	-		OOG6_101671
Panther	1	1.100	-	-	LDO	PTHR11081
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R423
SonicParanoid	1	1.000	-	-		X2084
TreeFam	1	0.960	-	-
	12	11.850