Protein Alignment tos and FEN1

DIOPT Version :9

• Sequence 1: NP_477145.1
• Gene: tos / 35119
• FlyBaseID: FBgn0015553
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_004102.1
• Gene: FEN1 / 2237
• HGNCID: 3650
• Length: 380
• Species: Homo sapiens
• Alignment Length: 408
• Identity: 99/408 - (24%)
• Similarity: 166/408 - (40%)
• Gaps: 82/408 - (20%)

  Fly     1 MGITGLIPFVGK-ASSQLHLKDIR---GSTVAVDTYCWLHKGVF-----GCAEKLARGEDTDVYI 56
            |||.||...:.. |.|.:...||:   |..||:|....:::.:.     |...:...||.|...:
Human     1 MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLM 65

  Fly    57 QYCLKYVNMLLSYDIKPILVFDGQHLPAKALTEKRRRDSRKQSKERAAELLRLGRIEEARSHMRR 121
            ....:.:.| :...|||:.||||:....|:....:|.:.|.:::::..:....|..:|.....:|
Human    66 GMFYRTIRM-MENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKR 129

  Fly   122 CVDVT--HDMALRLIRECRS----RNVDCIVAPYEADAQMAWLNRADVAQYIITEDSDLTLFGAK 180
            .|.||  |:      .||:.    ..:..:.||.||:|..|.|.:|.......|||.|...||:.
Human   130 LVKVTKQHN------DECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSP 188

  Fly   181 NIIFKLDLNGSGLLVEAEKL-----HLAMGCTEEKYHFDKFRRMCILSGCDYLDSLPGIGLAKAC 240
            .::..|..:      ||:||     ||:....|...:.::|..:|||.|.||.:|:.|||..:|.
Human   189 VLMRHLTAS------EAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAV 247

  Fly   241 KFILKTEQEDMRIALKKIPSYLNMRNLEVDDDYIENFMKAEATFRHMFIYNP------------- 292
            ..|.|.:      ::::|...|:.....|.    ||::..||   |.....|
Human   248 DLIQKHK------SIEEIVRRLDPNKYPVP----ENWLHKEA---HQLFLEPEVLDPESVELKWS 299

  Fly   293 ---LERRMQRLCALEDYETDERYCSNAGTLLEDSEQALHLALGNLNPF--------SMKRLDSWT 346
               .|..::.:|..:.: ::||..|....|.:..:.:..   |.|:.|        |.||.:
Human   300 EPNEEELIKFMCGEKQF-SEERIRSGVKRLSKSRQGSTQ---GRLDDFFKVTGSLSSAKRKE--- 357

  Fly   347 PEKAWPTPKNVKRSKHKS 364
                 |.||...:.|.|:
Human   358 -----PEPKGSTKKKAKT 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tos	NP_477145.1	PIN_EXO1	1..204	CDD:189027	58/222 (26%)
		H3TH_EXO1	214..291	CDD:188628	22/76 (29%)
FEN1	NP_004102.1	PTZ00217	1..373	CDD:240317	99/408 (24%)
		N-domain	1..104		27/103 (26%)
		I-domain	122..253		43/142 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..380		12/55 (22%)
		Interaction with PCNA. /evidence=ECO:0000269|PubMed:9305916	336..344		2/10 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810