DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tos and Gen1

DIOPT Version :9

Sequence 1:NP_477145.1 Gene:tos / 35119 FlyBaseID:FBgn0015553 Length:732 Species:Drosophila melanogaster
Sequence 2:NP_796305.3 Gene:Gen1 / 209334 MGIID:2443149 Length:908 Species:Mus musculus


Alignment Length:887 Identity:181/887 - (20%)
Similarity:308/887 - (34%) Gaps:264/887 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGITGLIPFVGKASSQLHLKDIRGSTVAVDTYCWL-----HKGVFGCAEKLARGEDTDVYIQYCL 60
            ||:..|...:......:||:|:.|.|:|||...|:     .|.:.|..:|        .:::...
Mouse     1 MGVNDLWQILEPVKQHIHLQDLSGKTIAVDLSLWVCEAQTVKKMIGTVKK--------PHLRNLF 57

  Fly    61 KYVNMLLSYDIKPILVFDGQHLPAKALTEKRRRDSR--KQSKERAAELLRLGRIEEARSHMRRCV 123
            ..::.|...::|.:.|.:|:....||....:|..:|  ...|.|:.        :..|||.:   
Mouse    58 FRISYLTQMNVKLVFVMEGEPPMLKADVISKRTQTRYGPSGKSRSQ--------KTGRSHFK--- 111

  Fly   124 DVTHDMALRLIRECRSRNVDCIVAPY-----EADAQMAWLNRADVAQYIITEDSDLTLFGAKNII 183
                    .::|||... ::|:..|:     ||:|..|:||.:......:|.|.|..|:||:.:.
Mouse   112 --------SVLRECLEM-LECLGMPWVQAAGEAEAMCAYLNASGHVDGCLTNDGDAFLYGAQTVY 167

  Fly   184 FKLDLNGSGLLVEAEKLHLAMGCTEEKYHFDK--FRRMCILSGCDYL-DSLPGIGLAKACKF--I 243
            ....:|.....|:.    ..:...:.|...|:  ...:.:|.||||| ..:||:|..:|.|.  |
Mouse   168 RNFTMNTKDPHVDC----YTISSIKSKLGLDRDALVGLAVLLGCDYLPKGVPGVGKEQALKLLQI 228

  Fly   244 LKTEQ---------ED-----MRIALKKI-----------PSYLNMRN---LEVDDDYIENFMKA 280
            .|.:.         ||     .:.|.||:           |.. :.||   |...|.|.|     
Mouse   229 FKGQSLLQRFNQWIEDPCYSVPQSAPKKVVHCSVCSHPGSPKD-HERNGCILCKSDKYCE----- 287

  Fly   281 EATFRHMFIYNPLERRMQRLCALEDYETD-------------ERYCSNAGTLLEDSEQALHLALG 332
                .|.:.|         ||..|.::||             ::.||..|....:..|...|...
Mouse   288 ----PHDYDY---------LCPCEWHQTDHNRHLSEIENNIKKKACSCEGFPFHEVIQEFLLNKN 339

  Fly   333 N-LNPFSMKRLD-----SWTPEK-AWPTPKNVKR-----SKHKSIWQTNFQSENTHTPKKEN--- 382
            . |.|.:.:|.|     .:|.:| .||:....::     :::..|       |..|..|..|   
Mouse   340 KMLKPITYQRPDLLLFQRFTVQKMEWPSHYACEKLLVLLTRYDMI-------ERKHGRKTSNQLQ 397

  Fly   383 PCALFFKKVDFVGKTLNEEIEANQ----------RLEQAKQTEAELF-------------NMYSF 424
            |..:...:|......|..|.|..:          :|......||.||             .:...
Mouse   398 PIRIVKPRVRNGVHCLEIEWEKPEHYVVEDGDPGKLSLLTMEEASLFEAAYPDAVAVYQKQLSET 462

  Fly   425 KAKRRRS----------PSREDSVDQERTPPPSPVHKS--RHNP-----------FAKERTGEEA 466
            |.::::|          |..:|.::.:......|..|:  :.||           .|:|.|....
Mouse   463 KGRKQKSMKNKPKGSHLPEADDVINSQSLMTLKPTSKAFPKQNPKINLENSPDPILAQESTSPSL 527

  Fly   467 NQRSPVVCENASLLRLLSPKKASPLDGEAGVKKVDSLKRSIFAKEQVQIRSRFFATQDEQ----- 526
            |  |.|..|||..|.|......||              |::..|:...: |.|..::..|     
Mouse   528 N--SFVSPENAPCLNLQEQLVPSP--------------RTLAIKQSKDV-SHFLVSECSQPSSSS 575

  Fly   527 ------TRLQREHL--------------RDTENDDMDEQKLSSHSGHKKLRLVCKDIPGKNPIRQ 571
                  |.||...:              |:|.:.|:..:..||        .:..|.       :
Mouse   576 HDISVITDLQLSTIDWAGTSFSNSPAVQRNTFSQDLASESESS--------AILPDF-------E 625

  Fly   572 RCSSQISDGETDTDTTASSLLESQDK-----GVPS------PLESQEDLNNSQPQIPTEGNTNST 625
            :.|.:...|.:|::.:...|.:|..:     |:.:      ||:.:..:.:|.||.....:..  
Mouse   626 QLSYESEQGTSDSEGSGRDLQQSNPEEQLLSGISALHLHDLPLKERIRIKSSCPQYNVGADAG-- 688

  Fly   626 TIRIKSLDLLLENSPEPTQESDRNNNDAI----ILLSDDSCSS---DQR-----ASSTSSSSQQR 678
               ::||.|.|:.|......||.::|.:.    :.|..:|.:|   |.|     .::||......
Mouse   689 ---LESLPLKLKGSCIAYSSSDGSSNFSKDLTGVYLHKESRNSKVLDSRLQENCGANTSLPYSFS 750

  Fly   679 QNFLPTSKRRVGLSKPSTAKKGTPKSRTNGKLGAVSQNQTKL 720
            ...:.||..:|||  |:.|....|:.........|.:|...|
Mouse   751 DKAVKTSSLQVGL--PTAAIPHNPRVAVKTTKNLVMKNSVCL 790

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tosNP_477145.1 PIN_EXO1 1..204 CDD:189027 47/214 (22%)
H3TH_EXO1 214..291 CDD:188628 27/109 (25%)
Gen1NP_796305.3 PIN_GEN1 2..206 CDD:350217 49/235 (21%)
XPG-N domain. /evidence=ECO:0000250|UniProtKB:Q17RS7 2..96 22/101 (22%)
XPG-I domain. /evidence=ECO:0000250|UniProtKB:Q17RS7 122..208 20/89 (22%)
H3TH_StructSpec-5'-nucleases 195..337 CDD:389913 36/160 (23%)
5'-3' exonuclease domain. /evidence=ECO:0000250|UniProtKB:Q17RS7 208..383 42/193 (22%)
Chromodomain. /evidence=ECO:0000250|UniProtKB:Q17RS7 389..463 12/73 (16%)
Chromo_2 397..457 CDD:376128 10/59 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 460..482 3/21 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 629..650 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 792..834
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 853..886
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0258
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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