DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tos and ERCC5

DIOPT Version :9

Sequence 1:	NP_477145.1	Gene:	tos / 35119	FlyBaseID:	FBgn0015553	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_000114.3	Gene:	ERCC5 / 2073	HGNCID:	3437	Length:	1186	Species:	Homo sapiens

Alignment Length:	838	Identity:	163/838 - (19%)
Similarity:	287/838 - (34%)	Gaps:	254/838 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGITGLIPFVGKASSQLHLKDIRGSTVAVDTYCWLHKGVFGCAEKLARGEDTD------VYIQYC 59
            ||:.||...:..:..|:..:.:.|..:|||...||::.:.|..::  .|...:      ::.:.|
Human     1 MGVQGLWKLLECSGRQVSPEALEGKILAVDISIWLNQALKGVRDR--HGNSIENPHLLTLFHRLC 63

  Fly    60 LKYVNMLLSYDIKPILVFDGQH--LPAKALTEKRRR------DSRKQSKERAAELLRLGRIEEAR 116
                 .||.:.|:||.||||..  |..:.|.::|:|      ||||.:::.....|:...|:.|.
Human    64 -----KLLFFRIRPIFVFDGDAPLLKKQTLVKRRQRKDLASSDSRKTTEKLLKTFLKRQAIKTAF 123

  Fly   117 SHMRRCVDVTHDMALRLIRECRSRNVDCIVAP---------YEADAQMAWLNRADVAQYIITEDS 172
            ...|       |.||..:.:.|..| |..|.|         .|.:.:..|..|.:..|.:..|
Human   124 RSKR-------DEALPSLTQVRREN-DLYVLPPLQEEEKHSSEEEDEKEWQERMNQKQALQEE-- 178

  Fly   173 DLTLFGAKNIIFKLDLNGSGLLVEAEKL--------HLAMGCTEEKYHFDKFRRMCILSGCDYLD 229
                      .|.   |...:.:|:|..        |..:  |:.| .|.|.||       ...:
Human   179 ----------FFH---NPQAIDIESEDFSSLPPEVKHEIL--TDMK-EFTKRRR-------TLFE 220

  Fly   230 SLPGIGLAKACKFILKTEQED-----MRIALKKIPSYLNMRNLEVDDDYIENFMKAEATFRHMFI 289
            ::|             .|.:|     ::..|||  :|||        .:||:..| |...:|
Human   221 AMP-------------EESDDFSQYQLKGLLKK--NYLN--------QHIEHVQK-EMNQQH--- 258

  Fly   290 YNPLERRMQRLCALEDYETDERYCSNAGTLLEDSEQALH-LALGNLNPFSMKRLDSWTPEKAWPT 353
                ...::|     .||.:..:.....:....||...| :.:..:...::..:||    ::.|:
Human   259 ----SGHIRR-----QYEDEGGFLKEVESRRVVSEDTSHYILIKGIQAKTVAEVDS----ESLPS 310

  Fly   354 PK-------NVKRSKHKSIWQTNFQSENTHTPKKENPCALFFKKVDFVGKTLNEEIEA-NQRLEQ 410
            ..       :||.|..:.:   ..:.|...||  .:|..|...:...:|.:..||:|: |:|..:
Human   311 SSKMHGMSFDVKSSPCEKL---KTEKEPDATP--PSPRTLLAMQAALLGSSSEEELESENRRQAR 370

  Fly   411 AKQTEAEL----FNMYSFKAKRRRSPSRED----SVDQERTPPPSP----VHKSRHN-------- 455
            .:...|.:    .:..:..|.:|.....||    :.|..:|..|..    ::.|..|
Human   371 GRNAPAAVDEGSISPRTLSAIKRALDDDEDVKVCAGDDVQTGGPGAEEMRINSSTENSDEGLKVR 435

  Fly   456 -----PFAKERTGEEANQRSPVVCENASLLRLLSPKKASPLDGEAGVKKVDSLKRSIFAKEQ--- 512
                 ||.........|.....|              ||..:|.   :..||:     .|||
Human   436 DGKGIPFTATLASSSVNSAEEHV--------------ASTNEGR---EPTDSV-----PKEQMSL 478

  Fly   513 VQIRSRFFATQDEQTRLQREHLRDTENDDMDEQKLSSHSGHKKLRLVCKDIPG------KNPIRQ 571
            |.:.:..|...||..      ::|.::....|..:..||          |.||      ..|...
Human   479 VHVGTEAFPISDESM------IKDRKDRLPLESAVVRHS----------DAPGLPNGRELTPASP 527

  Fly   572 RCSSQISDGETDTDTTA-------------SSLLESQDK---------GVPSPLESQEDLNNSQP 614
            .|::.:|..||..:...             ||||.|.|:         .|..|:..||  .:|..
Human   528 TCTNSVSKNETHAEVLEQQNELCPYESKFDSSLLSSDDETKCKPNSASEVIGPVSLQE--TSSIV 590

  Fly   615 QIPTEGNTN---------------------STTIRIKSLDLL-LENSPEPTQ-ESDRNNNDAIIL 656
            .:|:|...|                     ..|......||: :..:.||.: :|:.:.:|...:
Human   591 SVPSEAVDNVENVVSFNAKEHENFLETIQEQQTTESAGQDLISIPKAVEPMEIDSEESESDGSFI 655

  Fly   657 -----LSDDSCSSDQRASSTSSSSQQRQNFLPTSKRRVGLSKPSTAKKGTPKSRTNGK 709
                 :||:...::...:|...|.|..:..:.|.:........|..:..:.:...:|:
Human   656 EVQSVISDEELQAEFPETSKPPSEQGEEELVGTREGEAPAESESLLRDNSERDDVDGE 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tos	NP_477145.1	PIN_EXO1	1..204	CDD:189027	53/233 (23%)
tos	NP_477145.1	H3TH_EXO1	214..291	CDD:188628	17/81 (21%)
ERCC5	NP_000114.3	rad2	1..1029	CDD:273166	163/838 (19%)
		N-domain. /evidence=ECO:0000305\|PubMed:32522879	1..78		21/83 (25%)
		DNA-binding, may bind to the undamaged single-strand DNA of the DNA repair bubble. /evidence=ECO:0000269\|PubMed:32821917, ECO:0000312\|PDB:6TUW, ECO:0007744\|PDB:6TUX	31..67		6/42 (14%)
		Spacer region. /evidence=ECO:0000269\|PubMed:16246722	79..785		140/753 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..342		7/40 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..385		7/30 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	404..473		14/90 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..533		7/32 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..724		6/47 (13%)
		I-domain. /evidence=ECO:0000305\|PubMed:32522879	786..881
		DNA-binding, may bind to the undamaged single-strand DNA of the DNA repair bubble. /evidence=ECO:0000269\|PubMed:32821917, ECO:0000312\|PDB:6TUW, ECO:0007744\|PDB:6TUX	820..836
		DNA-binding, H2TH (helix-2turn-helix) motif which binds double-stranded DNA. /evidence=ECO:0000269\|PubMed:32821917, ECO:0000312\|PDB:6TUW, ECO:0007744\|PDB:6TUX	848..880
		DNA-binding, may bind double-stranded DNA. /evidence=ECO:0000269\|PubMed:32821917, ECO:0000312\|PDB:6TUW, ECO:0007744\|PDB:6TUX	912..918
		Interaction with PCNA. /evidence=ECO:0000269\|PubMed:9305916	981..1009
		Interaction with ERCC6/CSB. /evidence=ECO:0000269\|PubMed:16246722	1011..1186
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1056..1081
		Nuclear localization signal 1. /evidence=ECO:0000305\|PubMed:26812207	1057..1074
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1095..1186
		Nuclear localization signal 2. /evidence=ECO:0000305\|PubMed:26812207	1169..1186
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910