DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tos and Fen1

DIOPT Version :9

Sequence 1:	NP_477145.1	Gene:	tos / 35119	FlyBaseID:	FBgn0015553	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_001258543.1	Gene:	Fen1 / 14156	MGIID:	102779	Length:	380	Species:	Mus musculus

Alignment Length:	400	Identity:	100/400 - (25%)
Similarity:	164/400 - (41%)	Gaps:	73/400 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGITGLIPFVGK-ASSQLHLKDIR---GSTVAVDTYCWLHKGVF-----GCAEKLARGEDTDVYI 56
            |||.||...:.. |.|.:...||:   |..||:|....:::.:.     |...:...||.|...:
Mouse     1 MGIHGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLM 65

  Fly    57 QYCLKYVNMLLSYDIKPILVFDGQHLPAKALTEKRRRDSRKQSKERAAELLRLGRIEEARSHMRR 121
            ....:.:.| :...|||:.||||:....|:....:|.:.|.:::::..:....|..||.....:|
Mouse    66 GMFYRTIRM-MENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQEAGMEEEVEKFTKR 129

  Fly   122 CVDVT--HDMALRLIRECRS----RNVDCIVAPYEADAQMAWLNRADVAQYIITEDSDLTLFGAK 180
            .|.||  |:      .||:.    ..:..:.||.||:|..|.|.:|.......|||.|...||:.
Mouse   130 LVKVTKQHN------DECKHLLSLMGIPYLDAPSEAEASCAALAKAGKVYAAATEDMDCLTFGSP 188

  Fly   181 NIIFKLDLNGSGLLVEAEKL-----HLAMGCTEEKYHFDKFRRMCILSGCDYLDSLPGIGLAKAC 240
            .::..|..:      ||:||     ||:....|...:.::|..:|||.|.||.:|:.|||..:|.
Mouse   189 VLMRHLTAS------EAKKLPIQEFHLSRVLQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAV 247

  Fly   241 KFILKTEQEDMRIALKKIPSYLNMRNLEVDDDYIENFMKAEATFRHMFI--------------YN 291
            ..|.|.:      ::::|...|:.....|.    ||::..||  :.:|:              ..
Mouse   248 DLIQKHK------SIEEIVRRLDPSKYPVP----ENWLHKEA--QQLFLEPEVLDPESVELKWSE 300

  Fly   292 PLERRMQRLCALEDYETDERYCSNAGTLLEDSEQALHLALGNLNPF--------SMKRLDSWTPE 348
            |.|..:.:....|...::||..|....|.:..:.:..   |.|:.|        |.||.:   ||
Mouse   301 PNEEELVKFMCGEKQFSEERIRSGVKRLSKSRQGSTQ---GRLDDFFKVTGSLSSAKRKE---PE 359

  Fly   349 KAWPTPKNVK 358
            ...|..|..|
Mouse   360 PKGPAKKKAK 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tos	NP_477145.1	PIN_EXO1	1..204	CDD:189027	59/222 (27%)
tos	NP_477145.1	H3TH_EXO1	214..291	CDD:188628	22/90 (24%)
Fen1	NP_001258543.1	PTZ00217	1..359	CDD:240317	95/388 (24%)
		I-domain	122..253		43/142 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..380		11/48 (23%)
		Interaction with PCNA. /evidence=ECO:0000255\|HAMAP-Rule:MF_03140	336..344		2/10 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910