Protein Alignment tos and BIVM-ERCC5

DIOPT Version :10

• Sequence 1: NP_477145.1
• Gene: tos / 35119
• FlyBaseID: FBgn0015553
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001191354.2
• Gene: BIVM-ERCC5 / 100533467
• HGNCID: 43690
• Length: 1640
• Species: Homo sapiens
• Alignment Length: 617
• Identity: 122/617 - (19%)
• Similarity: 207/617 - (33%)
• Gaps: 189/617 - (30%)

  Fly    82 LPAKALTEKRRRDSRKQSKERAAELLRLGRIEEARSHMRRCVDVTHDMALRLIRECRSRNVDCIV 146
            |.:..|.::....::||.:||.|                  ..||..|.|......|...:..|.
Human  1193 LESNLLAQQNSLKAQKQQQERIA------------------ATVTGQMFLESQELLRLFGIPYIQ 1239

  Fly   147 APYEADAQMAWLNRADVAQYIITEDSDLTLFGAKNIIFKLDLNGSGLL--VEAEKLHLAMGCTEE 209
            ||.||:||.|.|:..|.....||:|||:.||||:: :::...|.:..:  .:....|..:|...
Human  1240 APMEAEAQCAILDLTDQTSGTITDDSDIWLFGARH-VYRNFFNKNKFVEYYQYVDFHNQLGLDR- 1302

  Fly   210 KYHFDKFRRMCILSGCDYLDSLPGIGLAKACKFILKTEQEDMRIALKKIPSYLNMRNLEVDDDYI 274
                :|...:..|.|.||.:.:|.:|...|.:.            |.:.|.:    .||....:.
Human  1303 ----NKLINLAYLLGSDYTEGIPTVGCVTAMEI------------LNEFPGH----GLEPLLKFS 1347

  Fly   275 ENFMKAEATFRHMFIYNPLERRMQRLCALEDYETDERYCSNAGTLLEDSEQALHLALGNLNPFSM 339
            |.:.:|:.        ||..|.                 :...|.::...:.|.|..|..||
Human  1348 EWWHEAQK--------NPKIRP-----------------NPHDTKVKKKLRTLQLTPGFPNP--- 1384

  Fly   340 KRLDSWTPEKAWPTPKNVKRSKHKSIW------------QTNFQSENTHTPKKENPCALFFKKVD 392
                  ...:|:..|. |..||...:|            |..|....|.|.:...|   ..|::|
Human  1385 ------AVAEAYLKPV-VDDSKGSFLWGKPDLDKIREFCQRYFGWNRTKTDESLFP---VLKQLD 1439

  Fly   393 FVGKTLNEEIEANQRLEQAKQTEAELFNMYSFKAKRRRSPSREDSVDQERTPPPSPVHKSRHNPF 457
                              |:||:..:.:.:     |.....:||
Human  1440 ------------------AQQTQLRIDSFF-----RLAQQEKED--------------------- 1460

  Fly   458 AKERTGEEANQRSPVVCENASLLRLLSPKKASPLDGEAGVKKVDSLKRSIFAKEQVQIRSRFFAT 522
            ||....:..|:  .|.|       :|..:|      ||...:::::        .|.:...|...
Human  1461 AKRIKSQRLNR--AVTC-------MLRKEK------EAAASEIEAV--------SVAMEKEFELL 1502

  Fly   523 QDEQTRLQREHLRDTENDDMDEQKLSSHSGHKKLRLVCKDIPGKNP----IRQRCSSQISDGETD 583
            ...:.:.|:..:.:|         |...|..|:.||  .|..|||.    :.:.|.|:.|||.:.
Human  1503 DKAKGKTQKRGITNT---------LEESSSLKRKRL--SDSKGKNTCGGFLGETCLSESSDGSSS 1556

  Fly   584 TDTTASSLLESQDK-GVPSPLESQEDLNNSQPQIPTEGNTNSTTIRIKSLDLLLENSPEPTQESD 647
            .|..:|||:..|.: ....|..|..|..||..:.|.: |..:||             ...:...|
Human  1557 EDAESSSLMNVQRRTAAKEPKTSASDSQNSVKEAPVK-NGGATT-------------SSSSDSDD 1607

  Fly   648 RNNNDAIILLSDDSCSSDQRASSTSSSSQQRQ 679
            ....:.::|::..|....:|.....:..::|:
Human  1608 DGGKEKMVLVTARSVFGKKRRKLRRARGRKRK 1639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tos	NP_477145.1	PIN_EXO1	1..202	CDD:350207	32/121 (26%)
		H3TH_EXO1	214..291	CDD:188628	14/76 (18%)
BIVM-ERCC5	NP_001191354.2	rad2	484..1483	CDD:273166	83/426 (19%)