DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tos and gen1

DIOPT Version :9

Sequence 1:	NP_477145.1	Gene:	tos / 35119	FlyBaseID:	FBgn0015553	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_001361766.1	Gene:	gen1 / 100145302	XenbaseID:	XB-GENE-940145	Length:	927	Species:	Xenopus tropicalis

Alignment Length:	820	Identity:	174/820 - (21%)
Similarity:	285/820 - (34%)	Gaps:	211/820 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGITGLIPFVGKASSQLHLKDIRGSTVAVDTYCWLHKGVFGCAEKLAR---GEDTDVYIQYCLKY 62
            ||:|.|...:|.....:.|:.:.|.|:|||...|:      |..::.:   |.....:::.....
Frog     1 MGVTDLWSILGPVKKHVPLESLAGKTLAVDLSIWV------CEAQMVKQMIGVVHKPHLRNLFFR 59

  Fly    63 VNMLLSYDIKPILVFDGQHLPAKALTEKRRRDSRKQSKERAAELLRLGRIEEARSHMRRCVDVTH 127
            ::.|....:|.:.|.:|:....||.|..:|.:.|......||. .:.|| ...:|.::.|:
Frog    60 ISSLNLLGVKLVFVSEGEAPKIKAETMSKRNEMRYGPSASAAP-PKAGR-SYFKSVLKECL---- 118

  Fly   128 DMALRLIRECRSRNVDCIVAPYEADAQMAWLNRADVAQYIITEDSDLTLFGAKNIIFKLDLNGSG 192
                 |:.||  ..:..:.|..||:|..|:||........||.|.|:.|:||:.:.....:|...
Frog   119 -----LMLEC--LGIPWVQAAGEAEAMCAYLNAHGYVDGCITNDGDVFLYGAQTVYRNFTMNVKD 176

  Fly   193 LLV---EAEKLHLAMGCTEEKYHFDKFRRMCILSGCDYL-DSLPGIGLAKACKFILKTEQEDMRI 253
            ..|   |..|:...:|...|     :...:.||.||||| ..:||:...:|.|.|.....|.
Frog   177 PHVDCYEVSKIKAQLGLDRE-----ELVGLAILLGCDYLPKGVPGVRKVQALKLIEMLNGES--- 233

  Fly   254 ALKKIPSYLNMRNLEVDDDYIENFMKAEATFRHMFI------YNPLERRMQRLCA----LEDYET 308
                    |..|..:.:.|..|...||.....|..:      ....||...::|.    .|.::.
Frog   234 --------LLQRFYQWEKDCNERGTKAPKKKPHCSVCCHPGSAKDHERNGCKMCGSDRFCEPHDY 290

  Fly   309 DERY-CSNAGTLLEDSEQALHLALGNLNPFSMKR-------------LDSWTPEKAWPTPKNVKR 359
            |.|. |.......|..|.::.        |::||             :|.:...|    .|.||.
Frog   291 DYRCPCDWHKEQREKQENSVE--------FNIKRKSLRCEGFPYRQVIDEFLINK----NKLVKV 343

  Fly   360 SKHKSIWQ-------TNFQSENTHTPKKENPCALFFKKVDFVGKTLNEEIEANQRLEQAKQTEAE 417
            .|    |.       .||.:|....|:..: |......:.:        .:.|:| :..::...:
Frog   344 LK----WGRPSLQCFQNFTAERMDWPRHYS-CEKLLVLLTY--------YDMNER-KAGRENGTQ 394

  Fly   418 LFNMYSFKAK-RRRSPSREDSVDQERTPPPSPVHKSRHNPFAKERTGEEANQRSPVV-CENASLL 480
            |..:...|.: |..||..|    .|...|.|.|       ||.:...|     ||:| .|..||.
Frog   395 LQAVRIVKTRIRNGSPCFE----IEWVKPDSYV-------FADDHPAE-----SPLVTIEEESLF 443

  Fly   481 RLLSPKKASPLDGEAGVKKVDSLKRSIFAKEQVQIRSRFFATQDEQTRLQREHLRDTENDDMDE- 544
            |...|...                 ::|.||:.:       .::.:.:.::...:....||:|:
Frog   444 RAAYPHVV-----------------TMFHKEKQE-------AEENKLKCKKSKPKSKAADDLDDV 484

  Fly   545 QKLSSHSGHKKLRLVCKDIPGKNPIRQRCSSQISDGETDT-------DTTASSLLESQDKGVPSP 602
            ..|.|       .|..|.:..|.|   ....|...|::|:       |:...||....|.||...
Frog   485 ASLLS-------ELSLKPVSEKQP---PLELQEDGGDSDSVHEKPARDSNFLSLSSDADSGVERG 539

  Fly   603 --LESQEDLNNSQPQIPTEGNTNSTTIRIKSLDLLLENSPEPTQESDRNNNDAIILLSDDSCSSD 665
              |:::.|         :|..|:.|.....|..|....:|..||.....:.:...::|:...||.
Frog   540 ILLDTKTD---------SEFFTSPTADNEPSNPLCSSPAPSNTQHLTAASPNISAVISELQLSSI 595

  Fly   666 QRASSTSSSSQQRQNFLPTSKRRVG-----LSKPST------------AKKGTPKSRTNGKLGAV 713
            ...|::.|.|.|.:.....|| .||     ..||:|            .:.|..:..|:.|:...
Frog   596 DWDSTSFSKSPQAEERTKGSK-EVGERGEFCYKPTTNNLETSGNKSKEVQNGIARPGTSNKVHLT 659

  Fly   714 SQNQTKLSMF-----------------------GFQTKPV 730
            :..|:.:..|                       ..|||||
Frog   660 NSKQSNVEDFHKLPLKERVLLKNAVQSGVPYPGKMQTKPV 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tos	NP_477145.1	PIN_EXO1	1..204	CDD:189027	50/208 (24%)
tos	NP_477145.1	H3TH_EXO1	214..291	CDD:188628	20/83 (24%)
gen1	NP_001361766.1	PIN_GEN1	2..206	CDD:350217	53/227 (23%)
		H3TH_StructSpec-5'-nucleases	195..336	CDD:389913	34/164 (21%)
		Chromo_2	396..456	CDD:376128	21/92 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910