Protein Alignment tos and ercc5

DIOPT Version :10

• Sequence 1: NP_477145.1
• Gene: tos / 35119
• FlyBaseID: FBgn0015553
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_012811722.1
• Gene: ercc5 / 100124735
• XenbaseID: XB-GENE-960380
• Length: 1251
• Species: Xenopus tropicalis
• Alignment Length: 797
• Identity: 146/797 - (18%)
• Similarity: 272/797 - (34%)
• Gaps: 276/797 - (34%)

  Fly     1 MGITGLIPFVGKASSQLHLKDIRGSTVAVDTYCWLHKGVFGCAEK----LARGEDTDVYIQYCLK 61
            ||:.||...:......::.:.:.|..:|:|...||::.|.|..::    :.......::.:.|
 Frog     1 MGVQGLWKLLECTGRPINAETLEGKILAIDISIWLNQAVKGARDRQGNAIQNAHLLTLFHRLC-- 63

  Fly    62 YVNMLLSYDIKPILVFDGQHLPAKALTEKRRRDSRKQSKERAAELLRLGRIEEARSHMRRCVDVT 126
               .||.:.|:||.||||:    ..|.:::....|:|.|:.|:        .||:.        |
 Frog    64 ---KLLFFRIRPIFVFDGE----APLLKRQTLAKRRQRKDNAS--------NEAKK--------T 105

  Fly   127 HDMALRLIRECRSRNVDCIVAPYEADAQMAWLNRADVAQYIITEDSDLTLFGAKNIIFKLDLNGS 191
            |:..||                       .:|.|..:                     |..|:|:
 Frog   106 HEKLLR-----------------------TFLKRQAI---------------------KAALSGN 126

  Fly   192 GLLVEAEKLHLAMGCTEEKYHFDKFRRMCILSGCDYLDSLPGIGLAKACKFILKTEQEDMRIALK 256
                                                                  .:..|
 Frog   127 ------------------------------------------------------KQSND------ 131

  Fly   257 KIPSYLNMRNLEVDDDYI-------ENFMKAEATFRHMFIYNPLERRM---QRLCALEDYETDER 311
            ::||:..:|..|.||.||       |.:...|...|      ..|.||   |||        .|.
 Frog   132 ELPSFSKVRRKETDDLYILPPLEDNEKYSSEEEEER------AWEERMTQKQRL--------QEE 182

  Fly   312 YCSNAGTLLEDSEQAL-------HLALGNLNPFSMKRLDSWTPEKAWPTPKNVKRSKHKSIWQTN 369
            :.:|..::..:||:.:       |..|.::..|:.:|.   |..:|.|...|            :
 Frog   183 FFANPSSVDIESEEFISLPPEVKHEILTDMKEFTKRRR---TLFEAMPEDSN------------D 232

  Fly   370 F-QSENTHTPKKENPCALFFKKVDFVGKTLNE----EIEANQRLEQA--KQTEAELF----NMYS 423
            | |.:.:...||.|    ..|.:|.|.|.||:    |::|....|..  |:.|....    |.:.
 Frog   233 FSQYQLSGLLKKNN----LNKCIDNVRKELNQQYSGEVQAQFEAEGGFLKEVETRRLVSEDNSHY 293

  Fly   424 FKAKRRRSPSREDSVDQERTPPPSPVHKSRHNPFAKERTGEEANQRSPVVCENASLLRLLSPKKA 488
            ...|..:|...|..||   :||.|..:.|...|    :|..:              |:|.|.:||
 Frog   294 ILIKGIQSKKEEKKVD---SPPQSVTYNSSQTP----KTYLD--------------LKLASARKA 337

  Fly   489 SPLDGEAGVKKVDSLKRSIFAKEQVQIRSRFFATQDEQTRLQREHLRDTENDDMDEQKLSSHSGH 553
            ..             .::..|.|:.......||.|:..|    |::.|   ::.|::|      |
 Frog   338 KS-------------SQAASADEEPPSPRTLFAIQEAMT----ENILD---ENWDDEK------H 376

  Fly   554 KKLRLVCKDIPGKNPIR--QRCSSQISDGETDTDTTASSLLESQDKG------VPSPLESQEDLN 610
            :|..:..::..|....|  |.....:::.|........::::|:.:.      |.|..:.:::..
 Frog   377 EKPSVSVREAEGNVSPRTLQAIYQVLAEDEAGQSNKKKTVVQSEREHKKAKVIVISSSDEEDNCL 441

  Fly   611 NSQPQ------IPTEGNTNSTTIRIK--SLDLLLE--NSPEPTQESDRNNNDAIILLSDDSCSSD 665
            |:|.:      :|.....:.::::.:  ::..:|:  :|...:|..:.:|...::.::|.:...|
 Frog   442 NNQGRTKAAFGVPLINRVSPSSVQCQESAVSSVLDCAHSRSVSQVEEPSNEVNVVEMADHNLQLD 506

  Fly   666 QR----ASST---SSSSQQRQ------NFLPTSKRRVGLSKPSTAKKGTPKSRTNGKLGAVSQN- 716
            .|    |..|   |||:...:      |.:|.:.....||...:.:|.......:|...: |::
 Frog   507 NRNVPIAQDTLIVSSSTGNAENPVTLCNTIPVTSEIPLLSVNRSIQKSVINPYNSGSFDS-SRDI 570

  Fly   717 --QTKLSMFGFQTKPVL 731
              |...:..||...||:
 Frog   571 SLQGDANKQGFSDNPVV 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tos	NP_477145.1	PIN_EXO1	1..202	CDD:350207	37/204 (18%)
		H3TH_EXO1	214..291	CDD:188628	12/83 (14%)
ercc5	XP_012811722.1	rad2	1..1112	CDD:273166	146/797 (18%)