DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43338 and Ccdc170

DIOPT Version :9

Sequence 1:	NP_001246080.1	Gene:	CG43338 / 35117	FlyBaseID:	FBgn0263079	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_214760.4	Gene:	Ccdc170 / 292266	RGDID:	1310945	Length:	718	Species:	Rattus norvegicus

Alignment Length:	820	Identity:	185/820 - (22%)
Similarity:	337/820 - (41%)	Gaps:	223/820 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PAIPFCQLDTSCSNTGITVTEHHHGLDLTTTLRSELAALSYKKERLTGELAEARAALCSKD---- 106
            |.:|            :|..:.:|..::...::|||||...:.|....||.|.|:.:.||:
  Rat    29 PEVP------------VTREQLNHYRNVAENVQSELAAALVRFECAQSELRELRSKMLSKEVCCQ 81

  Fly   107 ---ADIENLRAQAARQTALIGSLQSRLQNSESREQAVQA---RCDSTIQTVQREKRSSDERNKEL 165
               |::|:.:..:||:::|:.||:.|:|..:....|..|   |.:::...:.:|       |:||
  Rat    82 ELKAEMESYKENSARKSSLLVSLRGRIQELQEESAAFSASKIRAEASAHAMMKE-------NQEL 139

  Fly   166 ICKIQHLETHM-----ASEESQK---------EQIKAQLHDLLRRLSITLGMD-VCDGNQNSHAT 215
            :.|:..|:..:     |:|||:|         |:.:.||.|       .|.:| .|:     .|.
  Rat   140 MKKVLELDEKLQDCSKANEESKKQGSETLRRHEEFRTQLRD-------CLSLDKKCE-----EAP 192

  Fly   216 PECIISRAEEVMVELQRTKAKVSSTCDTLSSCENE-------LLNLKSLANIEKQRLTAQLDGAG 273
            .|.::.:.:|:..|....|.::::..:|:|..|.|       :|.|.:..:.|:.:..:..:...
  Rat   193 DEDLVLKLKELCKENTSLKGQLTTLEETVSVHEMEAKANRETILRLAADVSREQTKAASWAEEKD 257

  Fly   274 NHNHEL----EGRCRQYERDLQIQRDRLTESEINGEKLKEELRGFESRCHRLQNNL-------DR 327
            ..|.:|    |.| ...||:..:.::||..|:...:..|:||......|.:|..:|       ..
  Rat   258 KLNQDLLSAAEAR-TALEREAMLYQERLLASQRAWDASKQELNQLRKSCQQLDVSLKASREAATA 321

  Fly   328 TQGDRLQFLRGLSNLL----NVPEPCETLIKDKLR--EILAENQ-----AMHAQMHSLRDQLNSE 381
            :|.....|...|:.||    ::.|..|..|.:|:|  .|..|||     .:.||:..|..:|.:|
  Rat   322 SQSQNACFREKLAALLCSRFDIAESTEDAILEKIRVLGIEEENQKRMASQLEAQISELVGKLGNE 386

  Fly   382 HEKLKETQQTTECRLRSGEAQKCELTERLEKCHAEIHTLR---------KDHMGLS-----EFLQ 432
            .|..::..|      |:.||:|     :||....::..|.         :|::.|.     :||.
  Rat   387 SESHQKALQ------RAHEAEK-----KLEALQGQLSHLEGELLSGDVVRDNLNLEKQKYLKFLD 440

  Fly   433 RLALAMNWGECSAPPALGTDTNLMAENLLERAERLAAHCDHEAPHHHHHHHSPDKGCCDHGHGHG 497
            :|:..|..|..:|.  ||.|..|  :.:|.|.|:| .|.:..|
  Rat   441 QLSEKMKLGHIAAD--LGFDMRL--DVVLARIEQL-VHLESNA---------------------- 478

  Fly   498 KLRRERSCHDIPLKESSSVYNLQRRVRVLREQVQRRDLHLELLRRKLAIIEDGARGKCMLQGERD 562
                       .::..:..:||||:::..:|:::.:::|:.|||:|:..::.....:..|..|||
  Rat   479 -----------VIENKTMAHNLQRKLKTQKERLESKEVHMNLLRQKITQLQQEKEARSALAMERD 532

  Fly   563 EAVCRAKKAAKQVDKLSAQLADARSQIAEVKAQLAEAVEYKITSLERARKIDELTTQICDLEDEK 627
            ||....:|..|:|:::..:|:..:....|:||:||:..|.||.:||:.:.|::|.....:||..|
  Rat   533 EAHLSVRKLEKKVERMQKELSSCQEYNTELKAKLADTSELKIKTLEQTKAIEDLNQSRGELEKMK 597

  Fly   628 TRLLSQLNALKERLKSSCESNQNRRCRDEALINSMRDDVSRLSSQLSDANQRLSHLQSFRTSVAR 692
            .....:|..:...|:::.:..|..:.|..|:|.....::..|...|.:|.:|...|..||..|:.
  Rat   598 ENAEKKLMLVMSELETTVQEAQANQERTRAMIELASSELRILKKSLDEAERREQQLADFREVVSS 662

  Fly   693 TLHLR----DLPETDLLHRLQALCSAHQEFTMLSKRYETASPVGDHPCPRFDDPIPPSSHCRPPR 753
            .|.|.    .||:.:::..|:.|
  Rat   663 MLGLNVTSLALPDYEIIKCLERL------------------------------------------ 685

  Fly   754 ELSPPPTSFHHKATIHSGSSHHSPPSEHHHGSSSHVHNHH 793
                          ||   |||     |||      |:||
  Rat   686 --------------IH---SHH-----HHH------HHHH 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43338	NP_001246080.1	SMC_prok_B	<77..412	CDD:274008	95/388 (24%)
CG43338	NP_001246080.1	SMC_prok_A	305..>644	CDD:274009	89/370 (24%)
Ccdc170	XP_214760.4	SMC_prok_B	<30..>653	CDD:274008	163/703 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337632
Domainoid	1	1.000	155	1.000	Domainoid score	I4165
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69393
Inparanoid	1	1.050	154	1.000	Inparanoid score	I4230
OMA	1	1.010	-	-		QHG50021
OrthoDB	1	1.010	-	-		D178699at33208
OrthoFinder	1	1.000	-	-		FOG0007014
OrthoInspector	1	1.000	-	-		oto96950
orthoMCL	1	0.900	-	-		OOG6_108155
Panther	1	1.100	-	-	LDO	PTHR18863
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910