DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43338 and LOC100488825

DIOPT Version :9

Sequence 1:	NP_001246080.1	Gene:	CG43338 / 35117	FlyBaseID:	FBgn0263079	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_002933761.3	Gene:	LOC100488825 / 100488825	-ID:	-	Length:	778	Species:	Xenopus tropicalis

Alignment Length:	782	Identity:	162/782 - (20%)
Similarity:	329/782 - (42%)	Gaps:	148/782 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TNGNTPEDWQVFEVLFGADQDPKTIPAR----MTTMSPLPQPAIPF-CQLDTSCSNTGITVTEHH 68
            |.....::.|..|.|:..|:|.....||    ......|.:..||: .:|:.|.|...:.
Frog    31 TGSRRSQELQEKESLYANDEDRFPTNARHFPGNRVFDSLGEVTIPYDPELEFSSSRDQLM----- 90

  Fly    69 HGLDLTTTLRSELAALSYKKERLTGELAEARAALCSKDADIENLRAQA-------ARQTALIGSL 126
            |.........||.|||..|...|..|:::.::.|.:||..::.::.:.       |||.:.|.||
Frog    91 HYRRAAEASHSEYAALLVKNNSLQAEVSDLKSRLAAKDVFLQKVKDELVSYKENNARQLSQIHSL 155

  Fly   127 QSRLQNSESREQAVQA-RCDSTIQ--TVQREKRSSDERNKELICKIQHLET----HMASEESQKE 184
            :..::..|....:|.: :.::.::  .::|:       ||||..::|.||.    |:...|..::
Frog   156 KDHIKELEYMSASVNSGKAETNVELCALRRD-------NKELNERVQELENRIRMHLIEREKTEQ 213

  Fly   185 Q---IKAQLHDLLRRLSITLGMDVCDGNQNSHATPECIISRAEEVMVELQRTKAKVSSTCDTLSS 246
            :   ::.::.:.:.:|...|.|||    :........::::.|:::.|....|:|:||..:.|:.
Frog   214 KFNGLEKKMKESIGKLCSCLNMDV----EEQEDPLNILLTKVEKLIKEHFVQKSKLSSLEEVLAG 274

  Fly   247 CENE-------LLNLKSLANIEKQRLTAQLDGAGNHNHELEGRCRQYERDLQIQRDRLTESEING 304
            .:.|       ::.|  ::.|:|.:.|..:         ||.:.:..:|    :||....::.:.
Frog   275 RQVEYKASRETIVQL--VSEIDKHKKTVAV---------LEAQLKSIKR----ERDETLLAKQSA 324

  Fly   305 EKLKEELRG-----------FESRCHRLQ---NNLDRT---------------QGDRLQFLRGLS 340
            |:.||.|.|           |:....|.:   |.||||               |...:|....||
Frog   325 EQEKELLLGKIKDNHKEWSSFQQELVRKEKKLNELDRTLRTSDYEAKASHSLHQSFIIQLATVLS 389

  Fly   341 N-LLNVPEPCETLIKDKLREILAENQ-------AMHAQMHSLRDQLNSE----HEKLKETQQTTE 393
            | .:.||. .|..||::::||.:..|       .:..::..|..||:.:    ||.:.:..:..|
Frog   390 NGFITVPR-TEEAIKERIQEICSREQEWKVTTDELQEKVLKLTKQLDQQRDLYHEAVTKAYKAEE 453

  Fly   394 CRLRSGEAQKCELTERLEKCHAEIHTLRKDHMGLSEFLQRLALAMNWGECSAPPALGTDTNLMAE 458
            ....:.|:.| .|..:|............:...|.:||.::|..:|..:..:..:|.:    ..|
Frog   454 ILQENQESLK-HLKGKLTSEEMIKDGFNSERKKLKKFLLQMAEKLNVVQDISSGSLTS----QYE 513

  Fly   459 NLLERAERLAAHCDHEAPHHHHHHHSPDKGCCDHGHGHGKLRRERSCHDIPLKESSS-VYNLQRR 522
            .||.|||.:...               |||.                    ||:|.: :||||::
Frog   514 VLLNRAEEVTER---------------DKGF--------------------LKDSKTLIYNLQKK 543

  Fly   523 VRVLREQVQRRDLHLELLRRKLAIIEDGARGKCMLQGERDEAVCRAKKAAKQVDKLSAQLADARS 587
            :....|:::.:...:|.|.:|:..:|.....:.:|..|...:: .|:|..|:|::|..||::.:.
Frog   544 ITSQAEKIELKSTKIEQLEKKIKQLEKEKEQQLLLSAENSGSL-TAQKLQKKVERLQGQLSEMKI 607

  Fly   588 QIAEVKAQLAEAVEYKITSLERARKIDELTTQICDLEDEKTRLLSQLNALKERLKSSCESNQNRR 652
            ....:.|||.:..:.|..::::.:.|:||:..:..||..|.:...::.:||..|..|....:..:
Frog   608 TTQTLTAQLVDMSDLKERNMQQKKTIEELSRALEKLEKIKEKAAKKVVSLKTELDYSEHEFRGDK 672

  Fly   653 CRDEALINSMRDDVSRLSSQLSDANQRLSHLQSFRTSVAR----TLHLRDLPETDLLHRLQALCS 713
            .|.:.::.::.:::......|.:..:|...|..||.::.|    .|:...:|:.::..:|:.:..
Frog   673 ERCQHMVEAVTNELHTAKRALEEVAKREKQLVYFREAITRMMGFNLNTLAVPDHEIFDQLKRVLR 737

  Fly   714 AH 715
            .|
Frog   738 TH 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43338	NP_001246080.1	SMC_prok_B	<77..412	CDD:274008	86/399 (22%)
CG43338	NP_001246080.1	SMC_prok_A	305..>644	CDD:274009	84/380 (22%)
LOC100488825	XP_002933761.3	Smc	93..>703	CDD:224117	139/677 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	176	1.000	Domainoid score	I3560
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I3934
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007014
OrthoInspector	1	1.000	-	-		otm48451
Panther	1	1.100	-	-	O	PTHR18863
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060