DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43338 and ccdc170

DIOPT Version :9

Sequence 1:	NP_001246080.1	Gene:	CG43338 / 35117	FlyBaseID:	FBgn0263079	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_031758289.1	Gene:	ccdc170 / 100145067	XenbaseID:	XB-GENE-988262	Length:	764	Species:	Xenopus tropicalis

Alignment Length:	810	Identity:	191/810 - (23%)
Similarity:	340/810 - (41%)	Gaps:	159/810 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LNPRPTTNGNTPEDWQVFEVLFGADQDPKTIPARMTTMSPLPQPAIPFCQLDTSCS--------- 58
            :|..||::|....|         |....:.|.....|......|.||..:.|:...
Frog     9 INDNPTSSGAAKAD---------ASHSSRFIDVNSNTAFRSLSPTIPISRGDSGVQEQYPIHKWQ 64

  Fly    59 -----------NTG---------------------ITVTEHHHGLDLTTTLRSELAALSYKKERL 91
                       :||                     :|..:.:|...:....:||||||..|.|.:
Frog    65 AEHLDDSPATWSTGRQKTRGELLKSSFDPLLPDIPVTREQMNHYRIIAENAQSELAALHVKFESV 129

  Fly    92 TGELAEARAALCSKD-------ADIENLRAQAARQTALIGSLQSRLQNSE---SREQAVQARCDS 146
            ..||.:.||.|.||:       |::||.:...|||.:||.||::|||.:|   ||....:.|.|.
Frog   130 QTELLDLRARLASKEGSVQELRAEVENYKENTARQASLISSLRARLQETEEESSRFATSKTRADF 194

  Fly   147 TIQTVQREKRSSDERNKELICKIQHLETHMASEESQKEQIKAQLH-------DLLRRLSITLGMD 204
            .:|.|.:|       |:||..::..|::.:.|..:|.|:.|::..       ..|.:||..|.::
Frog   195 AMQAVLQE-------NQELKERMHDLDSRLKSSVAQWEESKSKASRYSRSHGQFLSQLSTCLNIN 252

  Fly   205 VCDGNQNSHATPECIISRAEEVMVELQRTKAKVSSTCDTLSSCENE-------LLNLKSLANIEK 262
            :    :......|.::|:..|:..:....|..::|...|::..|.|       ::.|.|..:.|:
Frog   253 I----RGQEEPEELLLSKINELYKDNTELKGSIASLEQTVNVHETESKGSRETIMRLVSEVSKEQ 313

  Fly   263 QRLTA---QLDGAGNHNHELEGRCRQYERDLQIQRDRLTESEINGEKLKEELRGFESRCHRLQNN 324
            ::.::   |||....:...........||:::|.:|||:.|:...|..|:||...:.....|..:
Frog   314 KKASSFAKQLDSLQKNLESTSDDKESLEREIKILKDRLSASQRAWEASKQELGQVKKSSTELDLS 378

  Fly   325 LDRTQGD-----------RLQFLRGLSNLLNVPEPCETLIKDKLREIL--AENQ-----AMHAQM 371
            |..|:|:           :......||:.....:|.|..|.:|:|::.  |||:     .:..::
Frog   379 LKSTRGEAKAAHSLHESFKETVAAALSHDSIAVKPKEEAILEKIRDMYHKAENRKTIISQLEERV 443

  Fly   372 HSLRDQLNSEHEKLKETQQTTECRLRSGEAQKCELTERLEKCHAEI-------HTLRKDHMGLSE 429
            ..|.:||.::    .|..|.:..|.|..|....:|..||:....|:       ..|..:.....:
Frog   444 FKLSEQLQTQ----TELHQESMSRARKAEQYLDDLGGRLKLAEGELVSGDVMRDNLSHEKQKYMK 504

  Fly   430 FLQRLALAMNWGECSAPPALGTDTNLMAENLLERAERLAAHCDHEAPHHHHHHHSPDKGCCDHGH 494
            ||::|:..|.....:..  :|.|..|  |.:|.||::|.
Frog   505 FLEQLSEKMKIDRVATD--VGFDMRL--EAILGRADQLV-------------------------- 539

  Fly   495 GHGKLRRERSCHDIPLKESSSVYNLQRRVRVLREQVQRRDLHLELLRRKLAIIEDGARGKCMLQG 559
               ||..     :..::..:....|||:::..:|.:..::||:||||:|:|.:|:..:.:..|..
Frog   540 ---KLET-----NAIIENKTRAQGLQRKLKAQKETIDSKELHMELLRKKIAQLEEEKQVRTALAV 596

  Fly   560 ERDEAVCRAKKAAKQVDKLSAQLADARSQIAEVKAQLAEAVEYKITSLERARKIDELTTQICDLE 624
            |||||....::..|:||:|..:|..|......:||:|::..|.||.::|:.:.|:||...:..||
Frog   597 ERDEANLTVRRLQKKVDRLQKELNVALDSNTGLKARLSDTNELKIKTIEQHKTIEELNKSVDQLE 661

  Fly   625 DEKTRLLSQLNALKERLKSSCESNQNRRCRDEALINSMRDDVSRLSSQLSDANQRLSHLQSFRTS 689
            .||.:...:|.::|..|:.:....|..:.|...|:..:..::..|...|.:..:|...|..||..
Frog   662 KEKGKTQKKLVSVKSELEFTERDAQEEKERSANLLEVVTSELKTLKKTLEEVVKREKQLVDFREV 726

  Fly   690 VARTLHLR----DLPETDLLHRLQALCSAH 715
            |:|.|.|.    .||:.:::.||:.|...|
Frog   727 VSRMLGLNVNVLALPDYEIIKRLEGLIHNH 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43338	NP_001246080.1	SMC_prok_B	<77..412	CDD:274008	98/379 (26%)
CG43338	NP_001246080.1	SMC_prok_A	305..>644	CDD:274009	87/363 (24%)
ccdc170	XP_031758289.1	SMC_prok_B	102..>720	CDD:274008	163/670 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	176	1.000	Domainoid score	I3560
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H69393
Inparanoid	1	1.050	176	1.000	Inparanoid score	I3934
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D178699at33208
OrthoFinder	1	1.000	-	-		FOG0007014
OrthoInspector	1	1.000	-	-		otm48451
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060