Protein Alignment Cyp310a1 and CYP4F12

DIOPT Version :10

• Sequence 1: NP_609891.1
• Gene: Cyp310a1 / 35115
• FlyBaseID: FBgn0032693
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 127/543 - (23%)
• Similarity: 212/543 - (39%)
• Gaps: 124/543 - (22%)

  Fly     2 WLLLPILLYSAVFLSVRHIYSHWRR-RGFPS-EKAGITWSFLQKAYRRE--FRHVEAICEAYQSG 62
            |||..||.::..|      |::.|| :.||. .|....|..|......|  .::...:...|..|
Human    29 WLLARILAWTYAF------YNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGLKNSTQMSATYSQG 87

  Fly    63 KDRLLG------IYCFFRPVLLVRNVELAQTILQQSNGHFSELK-W----------DYISGYRR- 109
            ....||      :.|....:..:.|...|  |..:.|.....|| |          |..|.:||
Human    88 FTVWLGPIIPFIVLCHPDTIRSITNASAA--IAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRM 150

  Fly   110 ------FNLLEKLAPMF-----------------GTKRLSEMFGQVQKVGDHLIHHLLDRQGQGC 151
                  ||:|:....:|                 |:.|| :||       :|:....||.. |.|
Human   151 LTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRL-DMF-------EHISLMTLDSL-QKC 206

  Fly   152 PQEVD--IQQKLRVYSVNI--IANLIYGLDINNFEHEDHILTSYLSHSQAS-------IQSFT-- 203
            ....|  .|::...|...|  ::.|:.....:..:|.|.:.  ||||....       :..||
Human   207 IFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDFLY--YLSHDGRRFHRACRLVHDFTDA 269

  Fly   204 LGRLPQKSSYTYRLRDLIKQSVELREDHGLIRKDILQLLVRFRNGNEVSGDKWQLEPINDADKLL 268
            :.|..:::..|..:.|..|...:.:      ..|.:.:|:       :|.|        :..|.|
Human   270 VIRERRRTLPTQGIDDFFKDKAKSK------TLDFIDVLL-------LSKD--------EDGKAL 313

  Fly   269 SIKRLAKVAEDLLKVSLDAVASTVTFTLLEILQEPLIVEKLRAEIKELSNENG--QLKFEELNGL 331
            |.:.:...|:..:....|..||.:::.|..:.:.|...|:.|.|::||..:..  ::::::|..|
Human   314 SDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQL 378

  Fly   332 RYMDMCLKETLRKYPPLPIIERVCRKSYSLPNSKFTIDEGKTLMVPLLAMHRDEKYFSEPMKYKP 396
            .::.||:||:||.:||.|.|.|.|.:...||:.: .|.:|.|.::.::.:|.:...:.:|..|.|
Human   379 PFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGR-VIPKGITCLIDIIGVHHNPTVWPDPEVYDP 442

  Fly   397 LRFLQTANDVGQCEDKTKSNVFIGFGIGGSQCVGQNFAKLVIKVALIKLLQNFHLELDANQVKTL 461
            .|| ...|..|:     ....||.|..|...|:||.||...:||.|..:|.:|....|
Human   443 FRF-DPENSKGR-----SPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPD------- 494

  Fly   462 KVSHRPAPFIHTKDGLKVKLKRR 484
                      ||:...|::|..|
Human   495 ----------HTEPRRKLELIMR 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp310a1	NP_609891.1	CYP6-like	62..478	CDD:410679	108/471 (23%)
CYP4F12	NP_076433.3	CYP4F	74..515	CDD:410772	112/492 (23%)