DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp310a1 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_609891.1	Gene:	Cyp310a1 / 35115	FlyBaseID:	FBgn0032693	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	550	Identity:	135/550 - (24%)
Similarity:	240/550 - (43%)	Gaps:	116/550 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WLLLPILLYSAVFLSVRHIYSHWRRRGFPSEKAGI----TWSFLQK--AYRREFRHVEAICEAYQ 60
            |.|: :|:.:.:|     ||..|..|.|  .|.||    .|.|:..  :|.:...:.:..| |.:
Zfish    11 WTLV-VLVITLLF-----IYGVWPHRFF--IKLGIPGPRPWPFVGTLLSYAKGLCNFDMEC-AKK 66

  Fly    61 SGKDRLLGIYCFFRPVLLVRNVELAQTILQQ---SN------------GHFS-------ELKWDY 103
            .||  :.|||....|:|:|.::|:.:.:|.:   ||            |.||       :.:|.
Zfish    67 YGK--VWGIYDGRLPILMVADLEVIKVVLVKECYSNFINRRKRTTGLAGPFSDGIIMVKDERWK- 128

  Fly   104 ISGYRRFNLLEKLAPMFGTKRLSEMFGQVQKVGDHLIHHLLDRQGQGCPQEVDIQQKLRVYSVNI 168
                   .:...|:|.|.:.||.|:|.......|..|.::   |.:...|.|.|::.:..||:::
Zfish   129 -------RMRSTLSPYFTSGRLKEIFPIAMTHADRFIKNM---QKKDPEQPVKIKEVVAPYSLDV 183

  Fly   169 IANLIYGLDINNFEH-EDHILTSYLSHSQAS--------IQSFTLGRLPQKS-----------SY 213
            |.:..:.:||::..: ||..:.:.....|.:        |..|....:|.|.           .:
Zfish   184 ITSSSFSVDIDSINNPEDPFVINVKKFIQFNMFNPLLLLILLFPSLAIPLKKMGVTLFSKSAMDF 248

  Fly   214 TYRLRDLIKQSVELREDHGLIRKDILQLLVRFRNGNEVSGDKWQLEPINDADKLLSIKRLAKVAE 278
            .|.:...||.. ..:|..|  |.|.|:|:::    |::..|:     |.|:|   :.::.||...
Zfish   249 FYSVLKKIKDD-HNKESEG--RVDFLKLMLQ----NQIPDDQ-----IQDSD---TSEQPAKGLT 298

  Fly   279 D--LLKVSL-------DAVASTVTFTLLEILQEPLIVEKLRAEIKELSNENGQLKFEELNGLRYM 334
            |  :|..||       :..::|:||.|..:...|..:|||..||.:....:..:.::.|..:.|:
Zfish   299 DHEILSQSLVFILGGYETTSTTLTFLLYNLATNPDCLEKLVEEIDKNFPLDTPITYDALMRMDYL 363

  Fly   335 DMCLKETLRKYPPLPIIERVCRKSYSLPNSKFTIDEGKTLMVPLLAMHRDEKYFSEPMKYKPLRF 399
            :|.:.|::|..|..|.:||..:|:..:  :..||.||..:.:|...:..|...:..|.:::|.||
Zfish   364 EMAINESMRLLPTAPRLERSAKKTVVI--NGLTIPEGTLVGIPTYVLSHDPDIWESPGEFRPERF 426

  Fly   400 LQTANDVGQCEDKTK--SNVFIGFGIGGSQCVGQNFAKLVIKVALIKLLQNFHLELDANQVKTLK 462
                    ..|:|::  ...||.||:|...|:|..:|.:::|:.::||||||       .|:|.|
Zfish   427 --------SPENKSEFLQYAFIPFGLGPRNCIGMRYAVMIMKLFVVKLLQNF-------SVETCK 476

  Fly   463 VSHRPAPF---IHTKDGLKVKLKRREINTK 489
            .:..|...   ...|..:.:||..|..|.|
Zfish   477 ETQIPLEMNVTFQPKVPITLKLIPRSCNKK 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp310a1	NP_609891.1	p450	69..454	CDD:299894	105/437 (24%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	117/492 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910