DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp310a1 and Cyp3a73

DIOPT Version :9

Sequence 1:	NP_609891.1	Gene:	Cyp310a1 / 35115	FlyBaseID:	FBgn0032693	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	XP_038945885.1	Gene:	Cyp3a73 / 498198	RGDID:	1595705	Length:	504	Species:	Rattus norvegicus

Alignment Length:	522	Identity:	124/522 - (23%)
Similarity:	225/522 - (43%)	Gaps:	109/522 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WLLLPILLYSAVFLSVRHIYSHWRRRGFPSEK------------AGITWSFLQKAYRREFRHVEA 54
            ||||.|:|........| .:..::::|.|..|            .|: |.|..:.|::
  Rat    12 WLLLAIILVLFYRFGTR-THGIFKKQGIPGPKPLPFLGTVLNYYRGL-WKFDMECYKK------- 67

  Fly    55 ICEAYQSGKDRLLGIYCFFRPVLLVRNVELAQTILQQS-----------------NGHFSELKWD 102
             |     ||  :.|::....||..:.:.|:.:::|.:.                 :...|..|.:
  Rat    68 -C-----GK--IWGLFDGQTPVFAIMDTEMIKSVLVKECFSVFTNRRNIGPVGIMSKSISVAKDE 124

  Fly   103 YISGYRRFNLLEKLAPMFGTKRLSEMFGQVQKVGDHLIHHLLDRQGQGCPQEVDIQQKLRVYSVN 167
            ....||.|     |:|.|.:.||.|||..::..||.|:.:|..:..:|.|  :.:::....||::
  Rat   125 EWKRYRAF-----LSPTFTSGRLKEMFPIIEHYGDILVKYLKQKVEKGKP--LAMKEVFGAYSMD 182

  Fly   168 IIANLIYGLDINN--------------FEHEDHILTSYLS----------HSQASIQSFTLGRLP 208
            :|.:..:.::||:              |:..|.....:||          :...:|..|....:.
  Rat   183 VITSTSFEVNINSINNPKDPFVEKVKKFQRFDFFDPLFLSVVLFPFLTPIYEMLNICLFPKDSVA 247

  Fly   209 QKSSYTYRLRDLIKQSVELREDHGLIRKDILQLLVRFRNGNEVSGDKWQLEPINDADKLLSIKRL 273
            ....:.||::   :..::.:..|   |.|.|||::   |.:..|.||...:.::|         :
  Rat   248 FFQKFVYRMK---QTRLDSKHKH---RVDFLQLMM---NAHNNSKDKVSHKALSD---------I 294

  Fly   274 AKVAEDLLKV--SLDAVASTVTFTLLEILQEPLIVEKLRAEIKELSNENGQLKFEELNGLRYMDM 336
            ..||:.::.:  |.:..:||::|.|..:...|...:||:.||...........::.:..:.|:||
  Rat   295 EIVAQAIIFIFASYETTSSTLSFVLYSLATHPDSQKKLQEEIDRALPNKAPPTYDTVMEMEYLDM 359

  Fly   337 CLKETLRKYPPLPIIERVCRKSYSLPNSKFTIDEGKTLMVPLLAMHRDEKYFSEPMKYKPLRFLQ 401
            .|.||.|.||....:||||:|...|..  ..|.:|..:|:|...:..|.:::.||.::.|.||.:
  Rat   360 VLNETPRLYPIGYRLERVCKKDIKLDG--VFIPKGSVVMIPFYTLQHDPQHWPEPEEFLPERFSK 422

  Fly   402 TANDVGQCEDKTKSN--VFIGFGIGGSQCVGQNFAKLVIKVALIKLLQNFHLELDANQVKTLKVS 464
                    |:|...:  |::.||.|...|:|..||.:.:|:||.|:||||..:|.......||:|
  Rat   423 --------ENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQLCEETQIPLKLS 479

  Fly   465 HR 466
            .:
  Rat   480 RQ 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp310a1	NP_609891.1	p450	69..454	CDD:299894	102/429 (24%)
Cyp3a73	XP_038945885.1	CYP3A	67..493	CDD:410743	110/465 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010