DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp310a1 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_609891.1	Gene:	Cyp310a1 / 35115	FlyBaseID:	FBgn0032693	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	539	Identity:	126/539 - (23%)
Similarity:	243/539 - (45%)	Gaps:	108/539 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 YSAVFL--SVRHIYSHW-----RRRGFPSEKAGITWSFLQK--AYRREFRHVEAICEAYQSGKDR 65
            ::.|||  ::.::|..|     ::.|.|..:   .|.|...  :|.:.|.:.:..| |.:.||
Zfish    11 WTLVFLVITLLYMYGVWPHGFFKKLGIPGPR---PWPFFGTFLSYTKGFFNFDMEC-AKKYGK-- 69

  Fly    66 LLGIYCFFRPVLLVRNVELAQTIL-QQSNGHFS---------------------ELKWDYISGYR 108
            :.|||....|:|:|.::|:.:||: ::....|:                     :.:|..|.|
Zfish    70 VWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREVNVDLAGPLADGISAVKDERWKRIRG-- 132

  Fly   109 RFNLLEKLAPMFGTKRLSEMFGQVQKVGDHLIHHLLDRQGQGCPQEVDIQQKLRVYSVNIIANLI 173
                  .|:|.|.:.||.|:|.......|..|.::..|..:   |.|.|::.:..||::::.:..
Zfish   133 ------TLSPYFTSGRLKEIFPIAMTHADRFIKNMQKRDHE---QPVKIKEVVAPYSLDVVTSSS 188

  Fly   174 YGLDINNFEH-EDHILTSYLSHSQASIQS-------------FTLGRLP----QKSSYTYRLRDL 220
            :.:||::..: :|..:|:..:..:.|:.|             ..||::.    .:|...:....|
Zfish   189 FSVDIDSINNPDDPFVTNIKNFLKFSLFSPLILFLTLFPSIANLLGKMGISVFSRSIMNFFYTAL 253

  Fly   221 IKQSVELREDHGLIRKDILQLLVRFRNGNEVSGDKWQLEPINDADKLLSIKRLAKVAEDLLKVSL 285
            .|...|.::.:|  |.|.|:|:::    |::..|:     ..|......:|.|..  .::|..|.
Zfish   254 RKIKDEHKDSNG--RVDFLRLMIQ----NQIPDDQ-----AKDTTSEQPVKGLTD--HEILSQSF 305

  Fly   286 -------DAVASTVTFTLLEILQEPLIVEKLRAEIKELSNENGQLKFEELNGLRYMDMCLKETLR 343
                   :..::|::|.|..:...|..:|||..||.:....:..:.::.|..:.|::|.:.|::|
Zfish   306 IFILGGYETTSTTLSFLLHNLATNPDCLEKLVEEIDKNFPLDTPISYDALMKMDYLEMSINESMR 370

  Fly   344 KYPPLPIIERVCRKSYSLPNSKFTIDEGKTLMVPLLAMHRDEKYFSEPMKYKPLRFLQTANDVGQ 408
            ..|..|.:||||:|:..|  :..||.:...:.:|...::||.:.:..|.:::|.||        .
Zfish   371 LLPTAPRLERVCKKTVEL--NGITIPKDTLVAIPTYVLNRDPQLWDSPQEFRPERF--------S 425

  Fly   409 CEDKTK--SNVFIGFGIGGSQCVGQNFAKLVIKVALIKLLQNFHLELDANQVKTLKVSHRP---A 468
            .|:|::  ...|:.||:|...|:|..||.:::|:.::||||||.||       |.|.:..|   .
Zfish   426 PENKSEFLQYAFMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSLE-------TCKETQIPLELT 483

  Fly   469 PFIHTKDGLKVKLKRREIN 487
            |....|..:.:||..|:.|
Zfish   484 PVFQPKVPITLKLTPRKRN 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp310a1	NP_609891.1	p450	69..454	CDD:299894	101/433 (23%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	116/504 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820