DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp310a1 and Cyp6a17

DIOPT Version :9

Sequence 1:	NP_609891.1	Gene:	Cyp310a1 / 35115	FlyBaseID:	FBgn0032693	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	115/518 - (22%)
Similarity:	223/518 - (43%)	Gaps:	60/518 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLPILLYSAVFLSVRHIYSHWRRRGFPSEKAGITWSFLQKAYRREFRHVEAICE----AYQSGK 63
            |.|.:::.|.:..:.|..:.:|:|||.|.::....:..::....:  ||:..|..    .|::..
  Fly     4 LALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKDWPNK--RHIAEIFRDYYFKYKNSD 66

  Fly    64 DRLLGIYCFFRPVLLVRNVELAQTILQQSNGHFSELKWDY-------------ISGYRRFNLLEK 115
            ....|.:.||....:|.::||.:.:|.:...||......|             |.|.:..:|..|
  Fly    67 YPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEIDDPLSATLFSIEGQKWRHLRHK 131

  Fly   116 LAPMFGTKRLSEMFGQVQKVGDHLIHHLLDRQGQGCPQEVDIQQKLRVYSVNIIANLIYGLDINN 180
            |.|.|.:.::..||..|.|||:.:......:......|.:::...:..|:.::|.|..:||:.|:
  Fly   132 LTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVARYTADVIGNCAFGLNCNS 196

  Fly   181 -FEHEDHILT----SYLSHSQASIQSFTLGRLPQKSS--------------YTYRLRDLIKQSVE 226
             ::.:...::    :...|...::....|...|:.|.              ||..:|:.|...:.
  Fly   197 LYDPKAEFVSIGKRAITEHRYGNMLDIFLFGFPKLSRRLRLKLNIQEAEDFYTKIVRETIDYRLR 261

  Fly   227 LREDHGLIRKDILQLLVRFRNGNEVSGDKWQLEPINDADKLLSIKRLAKVAEDLLKVSLDAVAST 291
            .:|.    |.|.:..|:.... ||.||        |..|.|...:.||: |........:..::|
  Fly   262 TKEK----RNDFMDSLIEMYK-NEQSG--------NSEDGLTFNELLAQ-AFIFFVAGFETSSTT 312

  Fly   292 VTFTLLEILQEPLIVEKLRAEIKEL-SNENGQLKFEELNGLRYMDMCLKETLRKYPPLPIIERVC 355
            :.|.|.|:.:...:.:|||.||..: ...|.:..:|.:..::|::..:.|||||||.|..:.|:.
  Fly   313 MGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMT 377

  Fly   356 RKSYSLPNSKFTIDEGKTLMVPLLAMHRDEKYFSEPMKYKPLRFLQTANDVGQCEDKTKSNVFIG 420
            ...:|..:.|:.|.:|..:::|.|.:|.|...:.||..:||.||  |..::.    ...|..::.
  Fly   378 DTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERF--TDEEIA----ARPSCTWLP 436

  Fly   421 FGIGGSQCVGQNFAKLVIKVALIKLLQNFHLELDANQVKTLKVSHRPAPFIHTKDGLKVKLKR 483
            ||.|...|:|..|..:...|.|..|::.:...:.......:|:..:.. .|..::|:.:|:::
  Fly   437 FGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNI-LISAENGIHLKVEK 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp310a1	NP_609891.1	p450	69..454	CDD:299894	97/417 (23%)
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	102/463 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461201
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	180	1.000	Inparanoid score	I2666
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	7.900