DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp310a1 and Cyp6g2

DIOPT Version :9

Sequence 1:	NP_609891.1	Gene:	Cyp310a1 / 35115	FlyBaseID:	FBgn0032693	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_610744.1	Gene:	Cyp6g2 / 36317	FlyBaseID:	FBgn0033696	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	570	Identity:	152/570 - (26%)
Similarity:	248/570 - (43%)	Gaps:	143/570 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWLLLPILLYSAV---FLSVRHIYSHWRRRGF---------------------PSEKAGITWSFL 41
            |.|:|.||:.|.:   ||:::..||:|||.|.                     |:|       |:
  Fly     1 MELVLLILVASLIGIAFLALQQHYSYWRRMGVREIRPKWIVGNLMGLLNMRMSPAE-------FI 58

  Fly    42 QKAYRREFRHVEAICEAYQSGKDRLLGIYCFFRPVLLVRNVELAQTILQQSNGHF------SELK 100
            .:.|    .|.:|..|.:       :||:.|.:|.||:|:.|:.:.||.:....|      |:.|
  Fly    59 SQLY----NHPDAENEPF-------VGIHVFHKPALLLRDPEMVRNILVKDFAGFSNRYSSSDPK 112

  Fly   101 WDYISGYRRFNLLE--------KLAPMFGTKRLSEMFGQVQKVGDHLIHHL----LDRQGQGCPQ 153
            .|.:.....|.|..        ||:|.|...||.:||..:::||..|..||    |..:...| .
  Fly   113 GDPLGSQNIFFLKNPAWKEVRLKLSPFFTGNRLKQMFPLIEEVGASLDAHLRQQPLHNERMRC-F 176

  Fly   154 EVDIQQKLRVYSVNIIANLIYGLDINNFEHEDHILTSYLSHSQASIQSFTLGR---------LPQ 209
            :::.::...:|:.::||.:.||:..|:|....   ..:..|.: |:..|.|.|         ||.
  Fly   177 DLEAKELCALYTTDVIATVAYGVSANSFTDPK---CEFRRHGR-SVFEFNLLRAAEFTLVFFLPH 237

  Fly   210 ----------KSSYTYRLRDLIKQSVELREDHGLIRKDILQLLVRFRNGNEV---SGDKWQLEPI 261
                      .:..|..||..|...:..||..|..|.|::.:|:.||...::   ||.|.|.  :
  Fly   238 LVPFVRFKVVPAEATRFLRKTINYVMSEREKSGQKRNDLIDILIEFRRSTQLAKASGIKDQF--V 300

  Fly   262 NDADKLLSIKRLAKVAEDLL--KVSLDAVASTVTFTLLEILQEPLIVEKLRAEIKE-LSNENGQL 323
            .:.|.|        ||:.:|  ....::.:||:.|.:.|:.::..:.::||.|||: |....||:
  Fly   301 FEGDIL--------VAQAVLFFTAGFESSSSTMAFAMYELAKDTDVQQRLREEIKDALVESGGQV 357

  Fly   324 KFEELNGLRYMDMCLKETLRKYPPLPIIERVCR--KSYSLP--NSKFTIDEGKTLMVPLLAMHRD 384
            ..:.:..|.:|.|.|.|.||.|||||.::|.|.  :.|||.  :.||.:.:|..:.:|..|:|.|
  Fly   358 TLKMIESLEFMQMILLEVLRMYPPLPFLDRECTSGRDYSLAPFHKKFVVPKGMPVYIPCYALHMD 422

  Fly   385 EKYFSEPMKYKPLRF------LQTANDVGQCEDKTKSNVFIGFGIGGSQCVGQNFAKLVIKVALI 443
            .:||.:|.|:.|.||      |.|            ...::.||:|...|:|:.|..|..||.|:
  Fly   423 PQYFPQPRKFLPERFSPENRKLHT------------PYTYMPFGLGPHGCIGERFGYLQAKVGLV 475

  Fly   444 KLLQN----------FHLELDANQVKTLKVSHRPAPFIHTKDGLKVKLKR 483
            .||:|          ..::||...:.|           ..|.|:.::|.|
  Fly   476 NLLRNHMITTSERTPHRMQLDPKAIIT-----------QAKGGIHLRLVR 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp310a1	NP_609891.1	p450	69..454	CDD:299894	123/447 (28%)
Cyp6g2	NP_610744.1	p450	36..511	CDD:278495	136/530 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461018
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	7	6.850