DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp310a1 and Cyp6t1

DIOPT Version :9

Sequence 1:	NP_609891.1	Gene:	Cyp310a1 / 35115	FlyBaseID:	FBgn0032693	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	125/535 - (23%)
Similarity:	230/535 - (42%)	Gaps:	101/535 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLPILLYSAVFLSVRHI-------YSHWRRRGFPSEKA----GITWSFLQKA--YRREFRHVEA 54
            :|||::|.....|.|..:       :.||||.|.|...|    |..|:.|:.|  :..:||.
  Fly    18 VLLPVVLRGGCLLVVTIVWLWQILHFWHWRRLGVPFVPAAPFVGNVWNLLRGACCFGDQFRE--- 79

  Fly    55 ICEAYQSGKDRLLGIYCFFRPVLLVRNVELAQTILQQSNGHFSELKWD--------------YIS 105
            :.|:.::.....:||.......||:|:..|.:.|:.:....||. :::              :.|
  Fly    80 LYESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVEDFAQFSS-RFETTDPTCDTMGSQNLFFS 143

  Fly   106 GYRRFNLLEKL-APMFGTKRLSEMFGQVQKVGDHLIHHLLDRQGQGCPQEVDIQQKLRVYSVNII 169
            .|..:....|: ||.|...::..|:|.::.:|..|..|:..:.......|::::|...:::.:||
  Fly   144 KYETWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCALFTTDII 208

  Fly   170 ANLIYGLDINNFEHED-------------------HILTSY----LSHSQASIQSFTLGRLPQKS 211
            |:|.:|::.::.::.:                   |:.|.:    |||        .:|......
  Fly   209 ASLAFGIEAHSLQNPEAEFRRMCIEVNDPRPKRLLHLFTMFFFPRLSH--------RVGTHLYSE 265

  Fly   212 SYTYRLRDLIKQSVELREDHGLIRKDILQLLVRFRNGNEVSGDKWQLEPINDADKLLSIKR---L 273
            .|...:|..:...:..|.:.|..|.|::.:.:             ||:....|:.:  |.|   .
  Fly   266 EYERFMRKSMDYVLSQRAESGENRHDLIDIFL-------------QLKRTEPAESI--IHRPDFF 315

  Fly   274 AKVAEDLLKVSLDAVASTVTFTLLEILQEPLIVEKLRAEIKEL--SNENGQLKFEELNGLRYMDM 336
            |..|..||....|..:||:||.|.|:.:...|.::||.|::..  |:::.||..:.:.||.|:..
  Fly   316 AAQAAFLLLAGFDTSSSTITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQ 380

  Fly   337 CLKETLRKYPPLPIIERVC--RKSYSLP----NSKFTIDEGKTLMVPLLAMHRDEKYFSEPMKYK 395
            .:.|.||.|||...::|.|  |..|.|.    .|.|.:..|..:.:.:|.:|||.:|:..|..:.
  Fly   381 VVDEVLRLYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFD 445

  Fly   396 PLRFLQTANDVGQCEDKTKSN--VFIGFGIGGSQCVGQNFAKLVIKVALIKLLQNFHLELDANQV 458
            |.||        ..|.:.:.:  .::.||.|...|:|....:|.|||.|:.:|.:|.:|:....:
  Fly   446 PERF--------SAEQRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTL 502

  Fly   459 KTLKVSHRPAPFIHT 473
            ..::..  |..|:.|
  Fly   503 PEMRFD--PKAFVLT 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp310a1	NP_609891.1	p450	69..454	CDD:299894	101/435 (23%)
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	104/457 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461006
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850