DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp310a1 and cyp3c1

DIOPT Version :9

Sequence 1:	NP_609891.1	Gene:	Cyp310a1 / 35115	FlyBaseID:	FBgn0032693	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_997838.1	Gene:	cyp3c1 / 324340	ZFINID:	ZDB-GENE-030131-3060	Length:	505	Species:	Danio rerio

Alignment Length:	546	Identity:	123/546 - (22%)
Similarity:	240/546 - (43%)	Gaps:	110/546 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WLLLPILLYSAVFLSVRHIYSH--WRRRGFPSEK----AGITWSFLQKAYRREFRHVEAICEAYQ 60
            |.|:.:::   ..|.:..::.|  :::.|.|..:    .|...|     |.:...:.:..| :.:
Zfish    11 WTLVVLVI---TLLLIYGVWPHGFFKKLGIPGPRPLPFVGTALS-----YSKGICNFDIEC-SKK 66

  Fly    61 SGKDRLLGIYCFFRPVLLVRNVELAQTIL-QQSNGHFS-------ELKWDYISG--------YRR 109
            .||  :.|||....|:|||.::|:.:||| :.....|:       :|...:..|        :||
Zfish    67 YGK--VWGIYDGRLPLLLVTDLEMIKTILVKDCYSTFTNRRNMNPDLVGPFADGITLVKDERWRR 129

  Fly   110 FNLLEKLAPMFGTKRLSEMFGQVQKVGDHLIHHLLDRQGQGCPQEVDIQQKLRVYSVNIIANLIY 174
              :...|:|.|.:.||.|:|.......|..|.: ::::....|  :.|:..:..||::::|:..:
Zfish   130 --IRSSLSPYFTSGRLKEIFPIAMTHADRFIKN-MEKKDPNLP--LKIKDVVAPYSLDVVASSSF 189

  Fly   175 GLDINNFEHEDHILTSYLSHSQASIQSF-----------TLGRLP--------------QKSSYT 214
            .:|.::..:.|....:       ||:||           .|...|              .:|:..
Zfish   190 SVDFDSINNPDDPFVT-------SIKSFFNINPLSPLFLLLAFCPSAANLLAKMGISVFSRSTTD 247

  Fly   215 YRLRDLIKQSVELREDHGLIRKDILQLLVRFRNGNEVSGDKWQLEPINDADKLLSIKRLAKVAED 279
            :..:.|.|...|..|.:|  |.|.|:|:::    |::..|:     :.|......:|.|..  .:
Zfish   248 FYYKALRKIKDEHNESNG--RVDFLKLMIQ----NQIPDDQ-----VKDTASEQPVKGLTD--HE 299

  Fly   280 LLKVSL-------DAVASTVTFTLLEILQEPLIVEKLRAEIKELSNENGQLKFEELNGLRYMDMC 337
            :|..|.       :..::|:::.|..:...|..:|||..||.:....:..:.::.|..:.|::|.
Zfish   300 ILSQSFIFILGGYETTSTTLSYLLYNLATNPDCLEKLVEEIDKNFPLDIPITYDALMRMDYLEMA 364

  Fly   338 LKETLRKYPPLPIIERVCRKSYSLPNSKFTIDEGKTLMVPLLAMHRDEKYFSEPMKYKPLRFL-Q 401
            :.|::|.:|..|.:||||:|:..:  :..||.:...:.:||..:.||...:..|.::||.||. :
Zfish   365 IHESMRVFPAGPRLERVCKKTVEI--NGITIPKNTLVGIPLYVLSRDPDLWESPNEFKPERFSPE 427

  Fly   402 TANDVGQCEDKTKSNVFIGFGIGGSQCVGQNFAKLVIKVALIKLLQNFHLELDANQVKTLKVSHR 466
            :..::.||       .|:.||:|...|:|..||.:::|:.::||||.:       .|:|.|.:..
Zfish   428 SKTEINQC-------AFMPFGLGPRNCIGMRFALMMMKLLVVKLLQKY-------TVETCKETQI 478

  Fly   467 PAP---FIHTKDGLKVKLKRREINTK 489
            |..   |...|..:.:||..|....|
Zfish   479 PVQLNFFFQPKVPITLKLIPRSHKEK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp310a1	NP_609891.1	p450	69..454	CDD:299894	100/433 (23%)
cyp3c1	NP_997838.1	p450	38..496	CDD:278495	114/506 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910