DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp310a1 and Cyp28c1

DIOPT Version :9

Sequence 1:	NP_609891.1	Gene:	Cyp310a1 / 35115	FlyBaseID:	FBgn0032693	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	120/538 - (22%)
Similarity:	211/538 - (39%)	Gaps:	88/538 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLPI-LLYSAVFLSVRHIYSHWRRRGFPSEKA--------GITWSFLQKAYRREFRHVEAICEA 58
            |||.| .|..|::..:...:.||||||....:|        .:.|.  ::.:..:.|.:    ..
  Fly     5 LLLGIATLLGAIYAFLVSNFGHWRRRGVTEPRALPLFGSFPNMIWP--RQHFTMDMRDI----YM 63

  Fly    59 YQSGKDRLLGIYCFFRPVLLVRNVELAQTILQQSNGHFS--------ELKWDYISGYRRFNLLE- 114
            :.......:|.|....|.|||....|...|...:..||.        ::..|.:.....| :||
  Fly    64 HYRNTHSYVGCYLLRAPKLLVLEPRLVYEIYVSAFSHFENNDASKMVDIAKDRLVALNPF-VLEG 127

  Fly   115 --------KLAPMFGTKRLSEMFGQVQKVGDHLIHHLLDRQGQGCPQEVD-IQQKLRVYSVNIIA 170
                    ..:.:....|:......:|:|...|...:..:...|  :::| |...|| ::...:.
  Fly   128 EEWRHQRAVFSTLLTNGRIRTTHAIMQRVCLDLCQFIAIKSAGG--KDLDCIDLGLR-FTGESLF 189

  Fly   171 NLIYGLDINNFEHEDHILTSYLSHSQASIQSFTLG----------RLPQ-------KSSYTYRLR 218
            :.:.|:....|  .|:.|.....:.:.|.::..|.          .||:       ..|:.....
  Fly   190 DCVLGIQARTF--TDNPLPVVRQNHEMSAENRGLAIAGAVHGLFPNLPRWLRPKVFPRSHDRFYG 252

  Fly   219 DLIKQSVELREDHGLIRKDILQLLVRFRNGNEVSGDKWQLEPINDADKLLSIKRLAKVAEDLLKV 283
            .:|.:::.||......|.|.:..|               ||...:.|  ||.:.:|..|...:..
  Fly   253 QMISEALRLRRSKHQERNDFINHL---------------LEMQRELD--LSEEDMASHAMTFMFD 300

  Fly   284 SLDAVASTVTFTLLEILQEPLIVEKLRAEIKELSNENGQL-KFEELNGLRYMDMCLKETLRKYPP 347
            .||..::::...||.:.:.|....:|..|: :|.|..|.| ..:.|..|.|:..|..|:||.||.
  Fly   301 GLDTTSNSIAHCLLLLGRNPDCQRRLYEEL-QLVNPGGYLPDLDALIDLPYLSACFNESLRIYPA 364

  Fly   348 LPIIERVCRKSYSLPNSKFT----IDEGKTLMVPLLAMHRDEKYFSEPMKYKPLRFLQTANDVGQ 408
            .....:.|.|.|.|..|..:    :..|..:|||:.|:|.|...:.||..::|.|||.     |.
  Fly   365 GGWASKTCTKEYELRGSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLD-----GG 424

  Fly   409 CEDKTKSNVFIGFGIGGSQCVGQNFAKLVIKVALIKLLQNFHLELDANQVKTLKVSHRPAPFIHT 473
            .::..:..:|:|||.|..||||......:.|.||..::|.|.:.:....:...::.  |..|:..
  Fly   425 LKNCKQQGIFLGFGNGPRQCVGMRLGLAMAKAALAAIVQRFEVVVSPRTLNGTELD--PLIFVGV 487

  Fly   474 -KDGLKVK-LKRREINTK 489
             |.|:.:: :.|:.:.||
  Fly   488 HKGGIWLQFVPRKNVTTK 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp310a1	NP_609891.1	p450	69..454	CDD:299894	97/424 (23%)
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	103/488 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460852
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850