DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp310a1 and Tbxas1

DIOPT Version :9

Sequence 1:	NP_609891.1	Gene:	Cyp310a1 / 35115	FlyBaseID:	FBgn0032693	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_036819.1	Gene:	Tbxas1 / 24886	RGDID:	3826	Length:	533	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	120/536 - (22%)
Similarity:	216/536 - (40%)	Gaps:	110/536 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 YSHWRRRGF----PSEKAGITWSFLQKAYRREFRHVEAICEAYQSGKDRLLGIYCFFRPVLLVRN 81
            :|..|:.|.    ||...|....|.|..:.   .|:| :.|.|    ..|.|.|...|..:::.:
  Rat    36 FSRLRKLGIRHPEPSPFVGNLMFFRQGFWE---SHLE-LRERY----GPLCGYYLGRRMYIVISD 92

  Fly    82 VELAQTILQQSNGHFS--------------------ELKWDYISGYRRFNLLEKLAPMFGTKRLS 126
            .::.:.:|.::..:||                    :.:|:.:.|        .|...|..::|:
  Rat    93 PDMIKEVLVENFSNFSNRMASGLEPKLIADSVLMLRDRRWEEVRG--------ALMSAFSPEKLN 149

  Fly   127 EMFGQVQKVGDHLIHHLLDRQGQGCPQEVDIQQKLRVYSVNIIANLIYGLDINNFEHEDHILTSY 191
            ||...:.:..:.|:.||......|  ...|||:....::.|::|::.:|:::|:   :|.....:
  Rat   150 EMTPLISQACELLLSHLKHSAASG--DAFDIQRCYCCFTTNVVASVAFGIEVNS---QDAPEDPF 209

  Fly   192 LSHSQ------------ASIQSF-----TLGR-LPQKSS------YTYRLRDLI----KQSVELR 228
            :.|.|            |.|.||     .|.| ||.|:.      :...:|::|    ||:.|.|
  Rat   210 VQHCQRVFAFSTPRPLLALILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALRDKQTAEER 274

  Fly   229 EDHGLIRKDILQLLVRFR------------------NGNEVSGDKWQ-LEPINDADKLLSIKRLA 274
                  |.|.||:::..:                  :..|..||..| ..|.:.| |.|::..:|
  Rat   275 ------RGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTA-KPLTVDEIA 332

  Fly   275 KVAEDLLKVSLDAVASTVTFTLLEILQEPLIVEKLRAEIKELSNENGQLKFEEL-NGLRYMDMCL 338
            ..|...|....:...:|::|....:...|...|:|..|:.....::...::..| .||.|:||.:
  Rat   333 GQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVV 397

  Fly   339 KETLRKYPPLPIIERVCRKSYSLPNSKFTIDEGKTLMVPLLAMHRDEKYFSEPMKYKPLRFLQTA 403
            .||||.|||.....|...:...:....  |..|..|.:.:.|:|.|.:::..|..:.|.||
  Rat   398 AETLRMYPPAFRFTREAAQDCEVLGQH--IPAGSVLEIAVGALHHDPEHWPNPETFDPERF---- 456

  Fly   404 NDVGQCEDKTKSNVFIGFGIGGSQCVGQNFAKLVIKVALIKLLQNFHLELDANQVKTLKVSHRPA 468
              ..:...:.|...::.||.|...|:|.....||:|:.|:::|..|..|........|::..:.|
  Rat   457 --TAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSA 519

  Fly   469 PFIHTKDGLKVKLKRR 484
              :..|:|:.||:..|
  Rat   520 --LCPKNGVYVKIVSR 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp310a1	NP_609891.1	p450	69..454	CDD:299894	99/452 (22%)
Tbxas1	NP_036819.1	p450	47..530	CDD:278495	115/520 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910